The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update
Open accessAbstract
Hepatic injury and subsequent hepatic failure due to both intentional and non-intentional overdose of acetaminophen (APAP) has affected patients for decades, and involves the cornerstone metabolic pathways which take place in the microsomes within hepatocytes. APAP hepatotoxicity remains a global issue; in the United States, in particular, it accounts for more than 50% of overdose-related acute liver failure and approximately 20% of the liver transplant cases. The pathophysiology, disease course and management of acute liver failure secondary to APAP toxicity remain to be precisely elucidated, and adverse patient outcomes with increased morbidity and mortality continue to occur. Although APAP hepatotoxicity follows a predictable timeline of hepatic failure, its clinical presentation might vary. N-acetylcysteine (NAC) therapy is considered as the mainstay therapy, but liver transplantation might represent a life-saving procedure for selected patients. Future research focus in this field may benefit from shifting towards obtaining antidotal knowledge at the molecular level, with focus on the underlying molecular signaling pathways.
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“Examples include alcohol148 and paracetamol,149 which damage pericentral hepatocytes and are responsible for the majority of fatal acute liver injury cases.”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [149]
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Cites
Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose
Smilkstein, M. J., Knapp, G. L., Kulig, K. W., & Rumack, B. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198812153192401 · Cited by 1,102
Jaeschke, H., McGill, M. R., & Ramachandran, A. (2012) · Drug Metabolism Reviews · doi:10.3109/03602532.2011.602688 · Cited by 972
(2018) · doi:10.1001/jama · Cited by 932
McGill, M. R., Sharpe, M. R., Williams, C. D., Taha, M., Curry, S. C., & Jaeschke, H. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59755 · Cited by 764
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Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning.
Prescott, L. F., Illingworth, R. N., Critchley, J. A., Stewart, M. J., Adam, R. D., & Proudfoot, A. T. (1979) · BMJ · doi:10.1136/bmj.2.6198.1097 · Cited by 667
Aminotransferase Elevations in Healthy Adults Receiving 4 Grams of Acetaminophen Daily
Watkins, P. B., Kaplowitz, N., Slattery, J. T., Colonese, C. R., Colucci, S. V., Stewart, P. W., & Harris, S. (2006) · JAMA · doi:10.1001/jama.296.1.87 · Cited by 631
Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning.
Prescott, L. F., Illingworth, R. N., Critchley, J., & Proudfoot, A. T. (1980) · BMJ · doi:10.1136/bmj.280.6206.46-b · Cited by 625
Improvement by Acetylcysteine of Hemodynamics and Oxygen Transport in Fulminant Hepatic Failure
Harrison, P. M., Wendon, J. A., Gimson, A. E. S., Alexander, G. J. M., & Williams, R. (1991) · New England Journal of Medicine · doi:10.1056/nejm199106273242604 · Cited by 585
Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity
Jaeschke, H., Williams, C. D., Ramachandran, A., & Bajt, M. L. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02501.x · Cited by 478
Cited by
Sorted by citations
Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders
Chopyk, D. M., & Grakoui, A. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.04.077 · Cited by 504
Ischaemia reperfusion injury in liver transplantation: Cellular and molecular mechanisms
Dar, W. A., Sullivan, E., Bynon, J. S., Eltzschig, H. K., & Ju, C. (2019) · Liver International · doi:10.1111/liv.14091 · Cited by 407
Abnormal liver enzymes: A review for clinicians
Kalas, M. A., Chavez, L., León, M., Taweesedt, P. T., & Surani, S. (2021) · World Journal of Hepatology · doi:10.4254/wjh.v13.i11.1688 · Cited by 407
Teschke, R. (2018) · Biomedicines · doi:10.3390/biomedicines6040106 · Cited by 244
Vorrink, S. U., Zhou, Y., Ingelman-Sundberg, M., & Lauschke, V. M. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy058 · Cited by 187
Metadata
- Authors
- Yoon, E. D., Babar, A., Choudhary, M. M., Kutner, M., & Pyrsopoulos, N.
- Affiliations
- University Hospital, Newark (US)
- Venue
- Journal of Clinical and Translational Hepatology
- Publisher
- Xia & He Publishing
- Published
- 2016-06-17
- Volume
- 4
- Issue
- 2
- Pages
- 131-42
- ISSN
- 2225-0719 (ISSN-L)
- 2310-8819
- PMC
- PMC4913076
- OpenAlex
- W2461975652
- Cited by
- 744
- References
- 78
- Citations by year
- 2026: 25 · 2025: 62 · 2024: 97 · 2023: 92 · 2022: 96 · 2021: 90 · 2020: 86 · 2019: 78 · 2018: 68 · 2017: 40 · 2016: 8
- FWCI
- 11.42
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Journal of Clinical and Translational Hepatology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Keywords
- acetaminophen hepatotoxicity, acetaminophen overdose, acute liver failure, liver transplantation, molecular pathways, antidotes
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