Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update

Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose

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Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

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The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

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Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

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Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning.

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Aminotransferase Elevations in Healthy Adults Receiving 4 Grams of Acetaminophen Daily

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Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning.

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Improvement by Acetylcysteine of Hemodynamics and Oxygen Transport in Fulminant Hepatic Failure

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Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

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Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders

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Ischaemia reperfusion injury in liver transplantation: Cellular and molecular mechanisms

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Abnormal liver enzymes: A review for clinicians

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Alcoholic Liver Disease: Alcohol Metabolism, Cascade of Molecular Mechanisms, Cellular Targets, and Clinical Aspects

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Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions

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Pain Management in Thoracic Surgery

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Acetaminophen (APAP or N-Acetyl-p-Aminophenol) and Acute Liver Failure

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Fluorescent probe for the imaging of superoxide and peroxynitrite during drug-induced liver injury

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Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms

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Interventions for paracetamol (acetaminophen) overdose

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A Broad‐Spectrum ROS‐Eliminating Material for Prevention of Inflammation and Drug‐Induced Organ Toxicity

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Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems

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N-Acetylcysteine: A potential therapeutic agent for SARS-CoV-2

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Loss of Sam50 in hepatocytes induces cardiolipin‐dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury

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Paracetamol: overdose-induced oxidative stress toxicity, metabolism, and protective effects of various compoundsin vivo and in vitro

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Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b

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Gut Microbiome and Response to Cardiovascular Drugs

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Mitochondrial–Lysosomal Axis in Acetaminophen Hepatotoxicity

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4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes

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The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury

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Unraveling the Role of Leptin in Liver Function and Its Relationship with Liver Diseases

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Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase

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Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury

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Hepatic Complications of Anorexia Nervosa

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Animal and Organoid Models of Liver Fibrosis

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Acetaminophen-induced liver injury: Molecular mechanism and treatments from natural products

Liao, J., Lu, Q., Li, Z., Li, J., Zhao, Q., & Li, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1122632 · Cited by 111

Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice

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The Preventive Effects and the Mechanisms of Action of Navel Orange Peel Hydroethanolic Extract, Naringin, and Naringenin in N-Acetyl-p-aminophenol-Induced Liver Injury in Wistar Rats

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Pharmacologic Stepwise Multimodal Approach for Postpartum Pain Management

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Microphysiological heart–liver body-on-a-chip system with a skin mimic for evaluating topical drug delivery

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Drug-induced liver injury and anti-hepatotoxic effect of herbal compounds: a metabolic mechanism perspective

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Chronic Inflammatory Diseases and Green Tea Polyphenols

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DNL 104, a Centrally Penetrant RIPK 1 Inhibitor, Inhibits RIP 1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers

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Role of pyroptosis in liver diseases

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p53 Up‐regulated Modulator of Apoptosis Induction Mediates Acetaminophen‐Induced Necrosis and Liver Injury in Mice

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Self-medication practice with analgesics (NSAIDs and acetaminophen), and antibiotics among nursing undergraduates in University College Farasan Campus, Jazan University, KSA

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Calcium Signaling in Liver Injury and Regeneration

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Nanotechnology for pain management: Current and future therapeutic interventions

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Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update

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Ameliorative and protective effects of ginger and its main constituents against natural, chemical and radiation-induced toxicities: A comprehensive review

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Medicinal Thiols: Current Status and New Perspectives

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Kaempferol suppresses acetaminophen-induced liver damage by upregulation/activation of SIRT1

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The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

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A review of the hepatoprotective effects of hesperidin, a flavanon glycoside in citrus fruits, against natural and chemical toxicities

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Cytochrome P450 Induction and Xeno‐Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator‐Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics

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Treating osteoarthritis pain: mechanisms of action of acetaminophen, nonsteroidal anti-inflammatory drugs, opioids, and nerve growth factor antibodies

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Dose Predictions for Drug Design

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Zebrafish as a Useful Model System for Human Liver Disease

Shimizu, N., Shiraishi, H., & Hanada, T. (2023) · Cells · doi:10.3390/cells12182246 · Cited by 75

Hepatoprotective effects of berberine on acetaminophen-induced hepatotoxicity in mice

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NF‐κB and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen‐induced acute hepatotoxicity in mice

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Maltol Improves APAP-Induced Hepatotoxicity by Inhibiting Oxidative Stress and Inflammation Response via NF-κB and PI3K/Akt Signal Pathways

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4-methylpyrazole protects against acetaminophen-induced acute kidney injury

Akakpo, J. Y., Ramachandran, A., Orhan, H., Curry, S. C., Rumack, B. H., & Jaeschke, H. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115317 · Cited by 74

Mouse Systems Genetics as a Prelude to Precision Medicine

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Efficacy and safety of magnesium isoglycyrrhizinate injection in patients with acute drug‐induced liver injury: A phase II trial

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Treatment of inflammatory bowel disease via green tea polyphenols: possible application and protective approaches

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Myristica fragrans Kernels Prevent Paracetamol-Induced Hepatotoxicity by Inducing Anti-Apoptotic Genes and Nrf2/HO-1 Pathway

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Drug Induced Liver Injury: Can Biomarkers Assist RUCAM in Causality Assessment?

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Sestrins in Physiological Stress Responses

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Impact of cell types and culture methods on the functionality of in vitro liver systems – A review of cell systems for hepatotoxicity assessment

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Medical large language models are susceptible to targeted misinformation attacks

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Acute liver failure: A review for emergency physicians

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Noninvasive monitoring of hepatic glutathione depletion through fluorescence imaging and blood testing

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VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis

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Hepatoprotective activity of metformin: A new mission for an old drug?

Iranshahy, M., Rezaee, R., & Karimi, G. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.02.004 · Cited by 58

N-Acetylcysteine and Its Immunomodulatory Properties in Humans and Domesticated Animals

Tieu, S., Charchoglyan, A., Paulsen, L., Wagter-Lesperance, L., Shandilya, U. K., Bridle, B. W., Mallard, B. A., & Karrow, N. A. (2023) · Antioxidants · doi:10.3390/antiox12101867 · Cited by 56

Exogenous exosomes from mice with acetaminophen-induced liver injury promote toxicity in the recipient hepatocytes and mice

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Natural Dietary Pigments: Potential Mediators against Hepatic Damage Induced by Over-The-Counter Non-Steroidal Anti-Inflammatory and Analgesic Drugs

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Formononetin protects against acetaminophen-induced hepatotoxicity through enhanced NRF2 activity

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Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity

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Selective FRET nano probe based on carbon dots and naphthalimide–isatin for the ratiometric detection of peroxynitrite in drug-induced liver injury

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A Scalable Approach for the Generation of Human Pluripotent Stem Cell-Derived Hepatic Organoids with Sensitive Hepatotoxicity Features

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The effects of mitochondrial transplantation in acetaminophen-induced liver toxicity in rats

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2,3,4′,5-tetrahydroxystilbene-2-O-β-D-glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2

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Acetaminophen-Induced Liver Injury Alters Expression and Activities of Cytochrome P450 Enzymes in an Age-Dependent Manner in Mouse Liver

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Hepatoprotective properties of red betel (Piper crocatum Ruiz and Pav) leaves extract towards H2O2-induced HepG2 cells via anti-inflammatory, antinecrotic, antioxidant potency

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Innovative use of shrimp shell powder in carbon paste electrode for the electrochemical detection of dopamine and paracetamol: Valorization, characterization and application

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N-acetylcysteine treatment blunts liver failure-associated impairment of locomotor activity

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The Bile Acid Receptor GPBAR1 Modulates CCL2/CCR2 Signaling at the Liver Sinusoidal/Macrophage Interface and Reverses Acetaminophen-Induced Liver Toxicity

Biagioli, M., Carino, A., Fiorucci, C., Marchianò, S., Giorgio, C. D., Bordoni, M., Roselli, R., Baldoni, M., Distrutti, E., Zampella, A., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901427 · Cited by 46

Epigenetic Mechanisms Contribute to Intraindividual Variations of Drug Metabolism Mediated by Cytochrome P450 Enzymes

Jin, J., & Zhong, X. (2023) · Drug Metabolism and Disposition · doi:10.1124/dmd.122.001007 · Cited by 47

Drug-Induced Liver Injury

Hamilton, L. A., Collins‐Yoder, A., & Collins, R. E. (2016) · AACN Advanced Critical Care · doi:10.4037/aacnacc2016953 · Cited by 47

Sestrin2 protects against acetaminophen-induced liver injury

Kim, S. J., Kim, K. M., Yang, J. H., Cho, S. S., Kim, J. Y., Park, S. J., Lee, S., Ku, S., Cho, I. J., & Ki, S. H. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.02.002 · Cited by 47

Mitochondrial Membrane Potential Drives Early Change in Mitochondrial Morphology After Acetaminophen Exposure

Umbaugh, D. S., Nguyen, N. T., Jaeschke, H., & Ramachandran, A. (2021) · Toxicological Sciences · doi:10.1093/toxsci/kfaa188 · Cited by 47

Acetaminophen cytotoxicity in HepG2 cells is associated with a decoupling of glycolysis from the TCA cycle, loss of NADPH production, and suppression of anabolism

Behrends, V., Giskeødegård, G. F., Bravo-Santano, N., Letek, M., & Keun, H. C. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2371-0 · Cited by 48

Histopathological changes of acetaminophen-induced liver injury and subsequent liver regeneration in BALB/C and ICR mice

Muhammad-Azam, F., Nur-Fazila, S. H., Ain-Fatin, R., Mustapha, N. M., & Yimer, N. (2019) · Veterinary World · doi:10.14202/vetworld.2019.1682-1688 · Cited by 45

Acetaminophen induced hepatotoxicity: An overview of the promising protective effects of natural products and herbal formulations

Chilvery, S., Yelne, A., Khurana, A., Saifi, M. A., Bansod, S., Anchi, P., & Godugu, C. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154510 · Cited by 45

Reverse Engineering To Characterize Redox Properties: Revealing Melanin’s Redox Activity through Mediated Electrochemical Probing

Kang, M., Kim, E., Temoçin, Z., Li, J., Dadachova, E., Wang, Z., Panzella, L., Napolitano, A., Bentley, W. E., & Payne, G. F. (2018) · Chemistry of Materials · doi:10.1021/acs.chemmater.8b02428 · Cited by 43

Ferroptosis and Acetaminophen Hepatotoxicity: Are We Going Down Another Rabbit Hole?

Jaeschke, H., Adelusi, O. B., & Ramachandran, A. (2021) · Gene Expression · doi:10.3727/105221621x16104581979144 · Cited by 44

The Role of Liver Zonation in Physiology, Regeneration, and Disease

Panday, R., Monckton, C. P., & Khetani, S. R. (2022) · Seminars in Liver Disease · doi:10.1055/s-0041-1742279 · Cited by 47

Liver‐specific deficiency of unc‐51 like kinase 1 and 2 protects mice from acetaminophen‐induced liver injury

Sun, Y., Li, T. Y., Song, L., Zhang, C., Li, J., Lin, Z., Lin, S., & Lin, S. (2018) · Hepatology · doi:10.1002/hep.29759 · Cited by 43

Egyptian perspectives on potential risk of paracetamol/acetaminophen-induced toxicities: Lessons learnt during COVID-19 pandemic

Mostafa, E. M. A., Tawfik, A. M., & abdelrahman, K. M. (2022) · Toxicology Reports · doi:10.1016/j.toxrep.2022.03.035 · Cited by 43

Modeling drug-induced liver injury and screening for anti-hepatofibrotic compounds using human PSC-derived organoids

Wu, X., Jiang, D., Yang, Y. A., Li, S., & Ding, Q. (2023) · Cell Regeneration · doi:10.1186/s13619-022-00148-1 · Cited by 48

A sensitive sensing platform for acetaminophen based on palladium and multi-walled carbon nanotube composites and electrochemical detection mechanism

Wu, Y., Wu, Y., Lv, X., Wu, L., Ding, Y., Chen, C., Lv, J., Feng, S., Chen, S., & Hao, Q. (2019) · Materials Chemistry and Physics · doi:10.1016/j.matchemphys.2019.121977 · Cited by 43

Herbal Therapy for the Treatment of Acetaminophen-Associated Liver Injury: Recent Advances and Future Perspectives

Chang, L., Xu, D., Zhu, J., Ge, G., Kong, X., & Zhou, Y. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00313 · Cited by 46

Drug repurposing of N-acetyl cysteine as antiviral against dengue virus infection

Sreekanth, G. P., Panaampon, J., Suttitheptumrong, A., Chuncharunee, A., Bootkunha, J., Yenchitsomanus, P., & Limjindaporn, T. (2019) · Antiviral Research · doi:10.1016/j.antiviral.2019.03.011 · Cited by 43

Hepatoprotective effect of Pandanus odoratissimus seed extracts on paracetamol-induced rats

Sinaga, E., Fitrayadi, A., Asrori, A., Rahayu, S., Suprihatin, S., & Prasasty, V. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2020.1865408 · Cited by 34

Treatment of Drug-Induced Liver Injury

Teschke, R. (2022) · Biomedicines · doi:10.3390/biomedicines11010015 · Cited by 43

Abnormal Liver Biochemistry Tests and Acute Liver Injury in COVID-19 Patients: Current Evidence and Potential Pathogenesis

McGrowder, D. A., Miller, F. G., Cross, M. A., Anderson-Jackson, L., Bryan, S., & Dilworth, L. (2021) · Diseases · doi:10.3390/diseases9030050 · Cited by 41

Long-term acetaminophen treatment induced liver fibrosis in mice and the involvement of Egr-1

Bai, Q., Yan, H., Sheng, Y., Jin, Y., Shi, L., Ji, L., & Wang, Z. (2017) · Toxicology · doi:10.1016/j.tox.2017.03.008 · Cited by 40

Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism

McGuire, M. R., Mukhopadhyay, D., Myers, S. L., Mosher, E. P., Brookheart, R. T., Kammers, K., Sehgal, A., Alpergin, E. S. S., Wolfgang, M. J., Bumpus, N. N., et al. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101316 · Cited by 40

Inhibition of p53 Sulfoconjugation Prevents Oxidative Hepatotoxicity and Acute Liver Failure

Xu, P., Xi, Y., Wang, P., Luka, Z., Xu, M., Tung, H., Wang, J., Ren, S., Feng, D., Gao, B., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.12.260 · Cited by 40

Current etiological comprehension and therapeutic targets of acetaminophen-induced hepatotoxicity

Chowdhury, A., Jahan, N., Adelusi, T. I., & Wang, S. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105102 · Cited by 107

Acetaminophen Hepatotoxicity and Acute Liver Failure

Chun, L. J., Tong, M. J., Busuttil, R. W., & Hiatt, J. R. (2009) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31818a3854 · Cited by 348

Recent Advances in Acetaminophen Hepatotoxicity

(2025) · MDPI eBooks · doi:10.3390/books978-3-7258-5540-7

Acetaminophen Hepatotoxicity

Larson, A. M. (2007) · Clinics in Liver Disease · doi:10.1016/j.cld.2007.06.006 · Cited by 460

Liver injury associated with Acetaminophen: A Review

Kholili, U., Nugroho, Y. H., Sugihartono, T., Nusi, I. A., & Setiawan, P. B. (2023) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2023.00329 · Cited by 7