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The Beneficial Effects of Lactobacillus GG Therapy on Liver and Drinking Assessments in Patients with Moderate Alcohol-Associated Hepatitis
Open accessAbstract
INTRODUCTION: We investigated the effect of daily oral Lactobacillus rhamnosus GG (LGG) in reducing liver injury/severity and drinking in patients with alcohol use disorder and moderately severe alcohol-associated hepatitis. METHODS: Forty-six male and female individuals with alcohol use disorder and moderate alcohol-associated hepatitis (12 ≤ model for end-stage liver disease score < 20, aged 21-67 years) received either LGG (n = 24) or placebo (n = 22). Data were collected/assessed at baseline and at 1, 3, and 6 months. RESULTS: LGG treatment was associated with a significant reduction in liver injury after 1 month. Six months of LGG treatment reduced heavy drinking levels to social or abstinence levels. DISCUSSION: LGG treatment was associated with an improvement in both liver injury and drinking.
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“Therefore, the use of probiotics in the treatment of alcohol dependence and substance dependence may be a promising treatment [25].”
From Research protocol of the efficacy of probiotics for the treatment of alcohol use disorder among adult males: A comparison with placebo and acceptance and commitment therapy in a randomized controlled trial (2023) · cites this paper as [25]
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“In a clinical study by Vatsalya et al. (2023), 24 subjects who consumed Lactobacillus rhamnosus GG(LGG) for 180 days showed a significant reduction in severe alcohol consumption and even achieved abstinence from alcohol compared to 22 subjects on placebo.”
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“In addition to this, subjects taking LGG had significantly better liver function than those consuming placebo.”
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Metadata
- Authors
- Vatsalya, V., Feng, W., Kong, M., Hu, H., Szabo, G., McCullough, A., Dasarathy, S., Nagy, L. E., Radaeva, S., Barton, B., Mitchell, M., & McClain, C. J.
- Affiliations
- University of Louisville (US)
- University of Massachusetts Medical School, Worcester, Massachusetts, USA;
- Cleveland Clinic (US)
- National Institute on Alcohol Abuse and Alcoholism (US)
- University of Massachusetts Chan Medical School (US)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Mitchell, Mack
- McClain, Craig J.
- ORCID
- Venue
- American Journal of Gastroenterology
- Published
- 2023-04-11
- Volume
- 118
- Issue
- 8
- Pages
- 1457-1460
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- PMC
- PMC10524173
- OpenAlex
- W4364379148
- Cited by
- 64
- References
- 14
- Citations by year
- 2026: 14 · 2025: 21 · 2024: 23 · 2023: 6
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01BX002996)
- National Institutes of Health (4u01aa021893-05)
- National Institute on Alcohol Abuse and Alcoholism (U01AA026934, U01-AA021893, U01AA026936, U01AA026264, K23AA029198, P50AA024337, U01AA026980)
- National Institute of General Medical Sciences (P20GM113226)
- National Institute of Environmental Health Sciences (P30ES030283)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- Lactobacillus rhamnosus GG, alcoholic hepatitis, alcoholism, probiotics, liver injury, heavy drinking, alcohol consumption reduction, MELD score, alcoholic liver disease
- MeSH terms
- Alcoholism, Female, Hepatitis, Alcoholic, Humans, Male, Severity of Illness Index, Probiotics, Lacticaseibacillus rhamnosus, End Stage Liver Disease
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