The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
The Beneficial Effects of Lactobacillus GG Therapy on Liver and Drinking Assessments in Patients with Moderate Alcohol-Associated Hepatitis
Open accessAbstract
INTRODUCTION: We investigated the effect of daily oral Lactobacillus rhamnosus GG (LGG) in reducing liver injury/severity and drinking in patients with alcohol use disorder and moderately severe alcohol-associated hepatitis. METHODS: Forty-six male and female individuals with alcohol use disorder and moderate alcohol-associated hepatitis (12 ≤ model for end-stage liver disease score < 20, aged 21-67 years) received either LGG (n = 24) or placebo (n = 22). Data were collected/assessed at baseline and at 1, 3, and 6 months. RESULTS: LGG treatment was associated with a significant reduction in liver injury after 1 month. Six months of LGG treatment reduced heavy drinking levels to social or abstinence levels. DISCUSSION: LGG treatment was associated with an improvement in both liver injury and drinking.
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“Therefore, the use of probiotics in the treatment of alcohol dependence and substance dependence may be a promising treatment [25].”
From Research protocol of the efficacy of probiotics for the treatment of alcohol use disorder among adult males: A comparison with placebo and acceptance and commitment therapy in a randomized controlled trial (2023) · cites this paper as [25]
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“In a clinical study by Vatsalya et al. (2023), 24 subjects who consumed Lactobacillus rhamnosus GG(LGG) for 180 days showed a significant reduction in severe alcohol consumption and even achieved abstinence from alcohol compared to 22 subjects on placebo.”
From Research protocol of the efficacy of probiotics for the treatment of alcohol use disorder among adult males: A comparison with placebo and acceptance and commitment therapy in a randomized controlled trial (2023) · cites this paper as Vatsalya et al. (2023)
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“In addition to this, subjects taking LGG had significantly better liver function than those consuming placebo.”
From Research protocol of the efficacy of probiotics for the treatment of alcohol use disorder among adult males: A comparison with placebo and acceptance and commitment therapy in a randomized controlled trial (2023) · cites this paper as Vatsalya et al. (2023)
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Self-citationA randomized clinical trial of fecal microbiota transplant for alcohol use disorder
Bajaj, J. S., Gavis, E. A., Fagan, A., Wade, J. B., Thacker, L. R., Fuchs, M., Patel, S., Davis, B., Meador, J., Puri, P., et al. (2021) · Hepatology · doi:10.1002/hep.31496 · Cited by 262
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Alcohol-related liver disease: Areas of consensus, unmet needs and opportunities for further study
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IL‐1 receptor antagonist plus pentoxifylline and zinc for severe alcohol‐associated hepatitis
Szabó, G., Mitchell, M. C., McClain, C. J., Dasarathy, S., BARTON, B. A., McCullough, A. J., Nagy, L. E., Kroll‐Desrosiers, A., Tornai, D., Min, H. A., et al. (2022) · Hepatology · doi:10.1002/hep.32478 · Cited by 106
Self-citationConverging Actions of Alcohol on Liver and Brain Immune Signaling
Szabó, G., & Lippai, D. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00011-7 · Cited by 96
Kirpich, I., McClain, C. J., Vatsalya, V., Schwandt, M. L., Phillips, M. J., Falkner, K. C., Zhang, L., Harwell, C., George, D. T., & Umhau, J. C. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13346 · Cited by 74
Self-citationWolstenholme, J. T., Saunders, J. M., Smith, M. L., Kang, J. D., Hylemon, P. B., González‐Maeso, J., Fagan, A., Zhao, D., Sikaroodi, M., Herzog, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34054-6 · Cited by 60
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ACG Clinical Guideline: Malnutrition and Nutritional Recommendations in Liver Disease
Singal, A. K., Wong, R. J., Dasarathy, S., Abdelmalek, M. F., Neuschwander‐Tetri, B. A., Limketkai, B. N., Petrey, J., & McClain, C. J. (2025) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003379 · Cited by 93
Self-citationGut-liver axis: Recent concepts in pathophysiology in alcohol-associated liver disease
Raya Tonetti, F., Eguileor, A., Mrdjen, M., Pathak, V., Travers, J., Nagy, L. E., & Llorente, C. (2024) · Hepatology · doi:10.1097/hep.0000000000000924 · Cited by 78
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Alcohol-associated liver disease: Natural history, management and novel targeted therapies
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Metadata
- Authors
- Vatsalya, V., Feng, W., Kong, M., Hu, H., Szabo, G., McCullough, A., Dasarathy, S., Nagy, L. E., Radaeva, S., Barton, B., Mitchell, M., & McClain, C. J.
- Affiliations
- University of Louisville (US)
- University of Massachusetts Medical School, Worcester, Massachusetts, USA;
- Cleveland Clinic (US)
- National Institute on Alcohol Abuse and Alcoholism (US)
- University of Massachusetts Chan Medical School (US)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Mitchell, Mack
- McClain, Craig J.
- ORCID
- Venue
- American Journal of Gastroenterology
- Published
- 2023-04-11
- Volume
- 118
- Issue
- 8
- Pages
- 1457-1460
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- PMC
- PMC10524173
- OpenAlex
- W4364379148
- Cited by
- 64
- References
- 14
- Citations by year
- 2026: 14 · 2025: 21 · 2024: 23 · 2023: 6
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01BX002996)
- National Institutes of Health (4u01aa021893-05)
- National Institute on Alcohol Abuse and Alcoholism (U01AA026934, U01-AA021893, U01AA026936, U01AA026264, K23AA029198, P50AA024337, U01AA026980)
- National Institute of General Medical Sciences (P20GM113226)
- National Institute of Environmental Health Sciences (P30ES030283)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- Lactobacillus rhamnosus GG, alcoholic hepatitis, alcoholism, probiotics, liver injury, heavy drinking, alcohol consumption reduction, MELD score, alcoholic liver disease
- MeSH terms
- Alcoholism, Female, Hepatitis, Alcoholic, Humans, Male, Severity of Illness Index, Probiotics, Lacticaseibacillus rhamnosus, End Stage Liver Disease
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