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Cited by 23Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and TreatmentGallbladder and Bile Duct Disorders

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Identification of Individuals at Increased Risk for Pancreatic Cancer in a Community-Based Cohort of Patients With Suspected Chronic Pancreatitis

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Jeon, Christie Y., Chen, Qiaoling, Yu, Wei, Dong, Elizabeth Y., Chung, Joanie, Pandol, Stephen J., Yadav, Dhiraj, Conwell, Darwin L., Wu, Bechien U.·2020·Clinical and Translational Gastroenterology
DOI 10.14309/ctg.0000000000000147PMC PMC7263650
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Abstract

OBJECTIVES: We lack reliable methods for identifying patients with chronic pancreatitis (CP) at increased risk for pancreatic cancer. We aimed to identify radiographic parameters associated with pancreatic cancer in this population. METHODS: We conducted a retrospective cohort study of patients with suspected CP within an integrated healthcare system in Southern California in 2006–2015. Patients were identified by a diagnostic code and confirmed by imaging findings (parenchymal calcification, ductal stones, glandular atrophy, pseudocyst, main duct dilatation, duct irregularity, abnormal side branch, or stricture) defined by the natural language processing of radiographic reports. We used Cox regression to determine the relationship of smoking, alcohol use, acute pancreatitis, diabetes, body mass index, and imaging features with the risk of incident pancreatic cancer at least 1 year after abnormal pancreas imaging. RESULTS: We identified 1,766 patients with a diagnostic code and an imaging feature for CP with a median follow-up of 4.5 years. There were 46 incident pancreatic cancer cases. Factors that predicted incident pancreatic cancer after 1-year of follow-up included obesity (hazard ratio 2.7, 95% confidence interval: 1.2–6.1) and duct dilatation (hazard ratio 10.5, 95% confidence limit: 4.0–27). Five-year incidence of pancreatic cancer in this population with duct dilatation was 6.3%. DISCUSSION: High incidence of pancreatic cancer in suspected patients with CP with pancreatic duct dilatation warrants regular surveillance for pancreatic cancer.

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Figure 1. Selection of patients with suspected chronic pancreatitis with abnormal radiographic pancreas imaging. KPSC, Kaiser Permanente Southern California.
Figure 1. Selection of patients with suspected chronic pancreatitis with abnormal radiographic pancreas imaging. KPSC, Kaiser Permanente Southern California.CC BY · PubMed Central
Figure 2. Cumulative incidence curve of pancreatic cancer ≥1 year after abnormal pancreas imaging in patients with suspected chronic pancreatitis.
Figure 2. Cumulative incidence curve of pancreatic cancer ≥1 year after abnormal pancreas imaging in patients with suspected chronic pancreatitis.CC BY · PubMed Central
Figure 3. Cumulative incidence curve of pancreatic cancer ≥1 year after abnormal pancreas imaging in patients with suspected chronic pancreatitis by presence of ductal dilatation.
Figure 3. Cumulative incidence curve of pancreatic cancer ≥1 year after abnormal pancreas imaging in patients with suspected chronic pancreatitis by presence of ductal dilatation.CC BY · PubMed Central

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Research works printed but not linked: 27

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Metadata

Authors
Jeon, C. Y., Chen, Q., Yu, W., Dong, E. Y., Chung, J., Pandol, S. J., Yadav, D., Conwell, D. L., & Wu, B. U.
Affiliations
  • Cedars-Sinai Medical Center (US)
  • Kaiser Permanente (US)
  • University of Pittsburgh Medical Center (US)
  • The Ohio State University Wexner Medical Center (US)
Corresponding author
Jeon, Christie Y.
ORCID
Venue
Clinical and Translational Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2020-04
Volume
11
Issue
4
Pages
e00147
ISSN
2155-384X (ISSN-L)
DOI
10.14309/ctg.0000000000000147
PMC
PMC7263650
OpenAlex
W3016150855
Cited by
23
References
1
Citations by year
2025: 5 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 3
FWCI
1.17
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical and Translational Gastroenterology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (U01DK108327, U01DK108306, U01DK108314)
Topics
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
  • Health Sciences › Medicine › Gastroenterology › Gallbladder and Bile Duct Disorders
Keywords
chronic pancreatitis, pancreatic cancer risk, pancreatic duct dilatation, obesity, cancer surveillance, radiological features, risk factors, smoking, alcohol consumption, diabetes mellitus, body mass index
MeSH terms
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Natural Language Processing, Pancreas, Pancreatic Neoplasms, Registries, Retrospective Studies, Tomography, X-Ray Computed, Incidence, Risk Assessment, Patient Selection, Pancreatitis, Chronic, Early Detection of Cancer, Electronic Health Records

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CoChat. (2026). Citation check: Identification of Individuals at Increased Risk for Pancreatic Cancer in a Community-Based Cohort of Patients With Suspected Chronic Pancreatitis. https://app.cochat.ai/papers/10.14309/ctg.0000000000000147
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Jeon, C. Y., Chen, Q., Yu, W., Dong, E. Y., Chung, J., Pandol, S. J., Yadav, D., Conwell, D. L., & Wu, B. U. (2020). Identification of Individuals at Increased Risk for Pancreatic Cancer in a Community-Based Cohort of Patients With Suspected Chronic Pancreatitis. Clinical and Translational Gastroenterology. https://doi.org/10.14309/ctg.0000000000000147