Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

Marx, Uwe·2016·ALTEX

DOI 10.14573/altex.1603161

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Extracellular Recordings of Field Potentials from Single Cardiomyocytes
Norbert Klauke, Godfrey L. Smith, Jonathan M. Cooper · 2006 · Biophysical Journal
Investigation of expression and activity levels of primary rat hepatocyte detoxication genes under various flow rates and cell densities in microfluidic biochips
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Novel scalable 3D cell based model for in vitro neurotoxicity testing: Combining human differentiated neurospheres with gene expression and functional endpoints
Ana Paula Terrasso, Catarina Pinto, Margarida Serra, Augusto Filipe, Susana Almeida, Ana Lúcia Anjos Ferreira, Pedro Pedroso, Catarina Brito, Paula M. Alves · 2015 · Journal of Biotechnology
Engineered three-dimensional microfluidic device for interrogating cell-cell interactions in the tumor microenvironment
Kathryn Hockemeyer, Chris Janetopoulos, Alexander Y. Terekhov, William H. Hofmeister, Anna E. Vilgelm, Lino A. Costa, John P. Wikswo, Ann J. Richmond · 2014 · Biomicrofluidics
Alternatives for skin sensitisation: Hazard identification and potency categorisation: Report from an EPAA/CEFIC LRI/Cosmetics Europe cross sector workshop, ECHA Helsinki, April 23rd and 24th 2015
David Basketter, Takao Ashikaga, Silvia Casati, Bruno Hubesch, Joanna S. Jaworska, Joop A. de Knecht, Robert Landsiedel, Irene Manou, Annette Mehling, Dirk Petersohn et al. · 2015 · Regulatory Toxicology and Pharmacology
Acute Functional Neurotoxicity of Lanthanum(III) in Primary Cortical Networks
Alexandra Gramowski, Konstantin Jügelt, Olaf H.-U. Schröder, Dieter G. Weiss, Steffen R Mitzner · 2010 · Toxicological Sciences
Label-Free Biosensor Methods in Drug Discovery
2015 · Methods in pharmacology and toxicology
Investigation of the hepatotoxicity of flutamide: Pro-survival/apoptotic and necrotic switch in primary rat hepatocytes characterized by metabolic and transcriptomic profiles in microfluidic liver biochips
Audrey Legendre, Sébastien Jacques, Florent Dumont, Jérôme Cotton, Patrick Paullier, Marie José Fleury, Éric Leclerc · 2014 · Toxicology in Vitro
A better prescription for drug-development financing
Mark Kessel, Frederick Frank · 2007 · Nature Biotechnology
Sensor-based cell and tissue screening for personalized cancer chemotherapy
Regina Kleinhans, Martin Brischwein, Pei Wang, Bernhard Becker, Franz Demmel, Tobias Schwarzenberger, M. Zottmann, Peter S. Wolf, Axel Niendorf, Bernhard Anton Wolf · 2012 · Medical & Biological Engineering & Computing
Selective control of liver and kidney cells migration during organotypic cocultures inside fibronectin-coated rectangular silicone microchannels
Éric Leclerc, R. Baudoin, Anne Corlu, Laurent Griscom, Jean Luc Duval, Cécile Legallais · 2006 · Biomaterials
Microfluidics and the Life Sciences
Holger Becker, Claudia Gärtner · 2012 · Science Progress
Evaluation of pulmonary alveolar epithelial integrity by the detection of restriction to diffusion of hydrophilic solutes of different molecular sizes
Gregory R. Mason, Adrien Michael Peters, E K Bagdades, M J Myers, D. E. Snook, J. M. B. HUGHES · 2001 · Clinical Science
Evaluation of helper-dependent canine adenovirus vectors in a 3D human CNS model
Daniel F. Simão, Catarina Pinto, P. Fernandes, Christopher J. Peddie, Stefania Piersanti, Lucy Collinson, Sara Salinas, Isabella Saggio, Giampietro Schiavo, Eric J. Kremer et al. · 2015 · Gene Therapy
In silico risk assessment for skin sensitization using artificial neural network analysis
Kyoko Tsujita‐Inoue, Tomomi Atobe, Morihiko Hirota, Takao Ashikaga, Hirokazu Kouzuki · 2015 · The Journal of Toxicological Sciences
Trends in Cell Culture Technology
Uwe Marx · 2012 · Advances in experimental medicine and biology
Integration of pharmacokinetic and NRF2 system biology models to describe reactive oxygen species production and subsequent glutathione depletion in liver microfluidic biochips after flutamide exposure
Éric Leclerc, Jérémy Hamon, Audrey Legendre, Frédéric Y. Bois · 2014 · Toxicology in Vitro
Label-free monitoring of whole cell vitality
D. Weiss, Martin Brischwein, H. Grothe, Bernhard Anton Wolf, Joachim Wiest · 2013 · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Development of a gastrointestinal tract microscale cell culture analog to predict drug transport.
Gretchen McAuliffe, Jung Yun Chang, Raymond P. Glahn, Michael Louis Shuler · 2008 · PubMed
New methods for investigation of neuronal migration in embryonic brain explants
Flávia C. Nery, Cintia Carla da Hora, Uzma Yaqub, Xuan Zhang, Deirdre M. McCarthy, Pradeep G. Bhide, Daniel Irimia, Xandra O. Breakefield · 2014 · Journal of Neuroscience Methods
Cell Signaling Experiments Driven by Optical Manipulation
F. Difato, G. Pinato, D. Cojoc · 2013 · International Journal of Molecular Sciences
Per Aspirin ad Astra…
Thomas Härtung · 2009 · Alternatives to Laboratory Animals
Characterization and simulation of peristaltic micropumps
Mathias Busek, M. Nötzel, Christoph Polk, Frank Sonntag · 2013 · Journal of sensors and sensor systems
Toxicity Assessment of Tobacco Products in Vitro
Joseph R. Manuppello, Kristie M. Sullivan · 2015 · Alternatives to Laboratory Animals
Dynamic control of extracellular environment in in vitro neural recording systems
Thomas M. Pearce, J.J. Williams, S.P. Kruzel, Matthew Gidden, Justin C. Williams · 2005 · IEEE Transactions on Neural Systems and Rehabilitation Engineering
Building benchtop human models
Amber Dance · 2015 · Proceedings of the National Academy of Sciences
A microdevice for parallelized pulmonary permeability studies
Ludivine Bol, Jean-Christophe Galas, Hervé Hillaireau, Isabelle Le Potier, Valérie Nicolas, Anne‐Marie Haghiri‐Gosnet, Elias Fattal, Myriam Taverna · 2013 · Biomedical Microdevices
Q&A: Hans Clevers
Eric Bender · 2015 · Nature
Microsatellites proximal to leptin and leptin receptor as risk factors for spina bifida
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Planar ruthenium oxide sensors for cell-on-a-chip metabolic studies
Martin Brischwein, H. Grothe, Joachim Wiest, M. Zottmann, Johann Ressler, B. A. Wolf · 2009 · mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)
Lab on a Chip: United States of America
Donald E. Ingber, George M. Whitesides · 2012 · Lab on a Chip
Multianalyte Microphysiometry Reveals Changes in Cellular Bioenergetics Upon Exposure to Fluorescent Dyes
Tesniem F. Shinawi, Danielle W. Kimmel, David E. Cliffel · 2013 · Analytical Chemistry
Fluorescent optical fiber sensors for cell viability monitoring
Ilia Sergachev, Alexander L. Rusanov, E. V. Trushkin, Dmitry A. Sakharov, Uwe Marx, Alexander Tonevitsky · 2013 · The Analyst
Moving from rats to cellular omics in regulatory toxicology: great challenge toward sustainability or “up-shit-creek without a paddle”?
Tewes Tralau, Andreas Luch · 2015 · Archives of Toxicology
Principles of Teratogenesis: Mode of Action of Thalidomide
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Nutrient depletion and metabolic profiles in breast carcinoma cell lines measured with a label-free platform
F Demmel, Martin Brischwein, Peter S. Wolf, F. Huber, Cornelia Pfister, Bernhard Anton Wolf · 2015 · Physiological Measurement
Determination of dynamic doxorubicin-EC50 value in an automated high-content workstation for cellular assays
Peter S. Wolf, Florian Hartl, Martin Brischwein, Bernhard Anton Wolf · 2011 · Toxicology in Vitro
Stem cells: scientific facts and fiction
2011 · Choice Reviews Online
Plasticity of Marrow Mesenchymal Stem Cells from Human First-Trimester Fetus: From Single-Cell Clone to Neuronal Differentiation
Yihua Zhang, Wenzheng Shen, Bingjie Sun, Changrong Lv, Zhongying Dou · 2010 · Cellular Reprogramming
Lessons from the withdrawal of rofecoxib: Observational studies should not be forgotten
Godfrey P. Oakley · 2004 · BMJ
Designer Cells Derived from Primary Tissue and Designed Cell Lines as a Sustainable Cell Source for Drug Discovery and Safety Assessment
Volker Sandig, Ingo Jordan · 2006
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O231: Long‐term persistence of patient‐derived hepatitis B virus infection in 3D microfluidic primary hepatocyte cultures
2014 · Journal of Viral Hepatitis
Correction for Dance, News Feature: Building benchtop human models
2015 · Proceedings of the National Academy of Sciences