The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Early Detection of Cancer: Past, Present, and Future
Abstract
Screening in both healthy and high-risk populations offers the opportunity to detect cancer early and with an increased opportunity for treatment and curative intent. Currently, a defined role for screening exists in some cancer types, but each screening test has limitations, and improved screening methods are urgently needed. Unfortunately, many cancers still lack effective screening recommendations, or in some cases, the benefits from screening are marginal when weighed against the potential for harm. Here we review the current status of cancer screening: we examine the role of traditional tumor biomarkers, describe recommended imaging for early tumor surveillance, and explore the potential of promising novel cancer markers such as circulating tumor cells (CTC) and circulating tumor DNA. Consistent challenges for all of these screening tests include limited sensitivity and specificity. The risk for overdiagnosis remains a particular concern in screening, whereby lesions of no clinical consequence may be detected and thus create difficult management decisions for the clinician and patient. If treatment is pursued following overdiagnosis, patients may be exposed to morbidity from a treatment that may not provide any true benefit. The cost-effectiveness of screening tests also needs to be an ongoing focus. The improvement of genomic and surveillance technologies, which leads to more precise imaging and the ability to characterize blood-based tumor markers of greater specificity, offers opportunities for major progress in cancer screening.
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Cites
Siegel, R., Ma, J., Zou, Z., & Jemal, A. (2014) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21208 · Cited by 11,499
Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening
The National Lung Screening Trial Research Team (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1102873 · Cited by 11,064
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Bettegowda, C., Sausen, M., Leary, R. J., Kinde, I., Wang, Y., Agrawal, N., Bartlett, B. R., Wang, H., Luber, B., Alani, R. M., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007094 · Cited by 5,067
Self-citationCirculating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
Cristofanilli, M., Budd, G. T., Ellis, M. J., Stopeck, A., Matera, J., Miller, M. C., Reuben, J. M., Doyle, G. V., Allard, W. J., Terstappen, L. W. M. M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040766 · Cited by 4,593
Prevention of Colorectal Cancer by Colonoscopic Polypectomy
Winawer, S. J., Zauber, A. G., Ho, M. N., O'Brien, M. J., Gottlieb, L. S., Sternberg, S. S., Waye, J. D., Schapiro, M., Bond, J. H., Panish, J. F., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292701 · Cited by 4,592
Antoniou, A., Pharoah, P. D. P., Narod, S., Risch, H. A., Eyfjord, J. E., Hopper, J. L., Loman, N., Olsson, H., Johannsson, O., Borg, Å., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/375033 · Cited by 3,680
Screening for Lung Cancer: U.S. Preventive Services Task Force Recommendation Statement
Moyer, V. A., & on behalf of the U.S. Preventive Services Task Force* (2014) · Annals of Internal Medicine · doi:10.7326/m13-2771 · Cited by 2,632
Screening for Prostate Cancer: U.S. Preventive Services Task Force Recommendation Statement
Moyer, V. A., & on behalf of the U.S. Preventive Services Task Force* (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-2-201207170-00459 · Cited by 2,522
Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement
US Preventive Services Task Force, Bibbins-Domingo, K., Grossman, D. C., Curry, S. J., Davidson, K. W., Epling, J. W., García, F. A. R., Gillman, M. W., Harper, D. M., Kemper, A. R., et al. (2016) · JAMA · doi:10.1001/jama.2016.5989 · Cited by 2,509
An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
Newman, A. M., Bratman, S. V., To, J., Wynne, J. F., Eclov, N. C. W., Modlin, L. A., Liu, C. L., Neal, J. W., Wakelee, H. A., Merritt, R. E., et al. (2014) · Nature Medicine · doi:10.1038/nm.3519 · Cited by 2,220
Cited by
Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies
Wang, S., Zhang, K., Tan, S., Xin, J., Yuan, Q., Xu, H., Xu, X., Liang, Q., Christiani, D. C., Wang, M., et al. (2021) · Molecular Cancer · doi:10.1186/s12943-020-01298-z · Cited by 331
Biosensing based on field-effect transistors (FET): Recent progress and challenges
Sadighbayan, D., Hasanzadeh, M., & Ghafar-Zadeh, E. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.116067 · Cited by 305
A comprehensive review of deep learning in colon cancer
Pacal, I., Karaboga, D., Basturk, A., Akay, B., & Nalbantoglu, U. (2020) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2020.104003 · Cited by 283
Convolutional neural network models for cancer type prediction based on gene expression
Mostavi, M., Chiu, Y.-C., Huang, Y., & Chen, Y. (2020) · BMC Medical Genomics · doi:10.1186/s12920-020-0677-2 · Cited by 264
Badidi, E. (2023) · Future Internet · doi:10.3390/fi15110370 · Cited by 113
Metadata
- Authors
- Schiffman, J. D., Fisher, P. G., & Gibbs, P.
- Venue
- American Society of Clinical Oncology Educational Book
- Published
- 2015-05
- Issue
- 35
- Pages
- 57-65
- ISSN
- 1548-8748 (ISSN-L)
- 1548-8756
- OpenAlex
- W1566274562
- Cited by
- 327
- References
- 72
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schiffman, J. D., Fisher, P. G., & Gibbs, P. (2015). Early Detection of Cancer: Past, Present, and Future. American Society of Clinical Oncology Educational Book. https://doi.org/10.14694/edbook_am.2015.35.57
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
