Impact of interval walking training managed through smart mobile devices on albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes
Open accessAbstract
Background: Interval walking training has demonstrated more pronounced positive effects on physical fitness and metabolism in type 2 diabetes (T2D), compared to continuous walking. One of the pathogenic mechanisms of T2D is associated with derangements in leptin/adiponectin axis, which might predispose affected individuals to vascular inflammation and albuminuria. The aim of this study was to investigate the effects of interval walking training delivered through smart mobile devices upon albuminuria and leptin/adiponectin ratio in patients with T2D. Methods: Patients with T2D aged 35–75 were randomized into control ( n = 26) and interval training (IT, n = 14) groups. Patients in IT group had to perform three 60‐min interval walking sessions (3 min intervals of slow and fast walking with the intensity of 40% and 70% of the peak energy expenditure) per week delivered by smartphone application for four months. The adherence to training was monitored remotely. Outcome measures were albuminuria, leptin/adiponectin ratio, obesity indicators, and glycaemic control. Leptin and adiponectin concentration was measured in serum samples by Luminex technology. Results: In the IT group compared to control group, we observed a statistically significant decrease in albuminuria ( p = .002) and leptin/adiponectin ratio ( p = .01), as well as a decrease in HbA1c close to statistical significance ( p = .09). In IT group, changes in leptin/adiponectin ratio correlated significantly with changes in hip circumference ( p = .024). Conclusion: Interval walking training is beneficial for vascular health in T2D via impact on albuminuria and leptin/adiponectin ratio.
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Evidence suggests reductions in leptin/adiponectin ratio.
“evidence suggests reductions in leptin/adiponectin ratio (40)”
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Cites
Cosentino, F., Grant, P. J., Aboyans, V., Bailey, C. J., Ceriello, A., Delgado, V., Federici, M., Filippatos, G., Grobbee, D. E., Hansen, T. B., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz486 · Cited by 4,763 · see citing works
Physical activity/exercise and diabetes: A position statement of the American Diabetes Association
Colberg, S. R., Sigal, R. J., Yardley, J. E., Riddell, M. C., Dunstan, D. W., Dempsey, P. C., Horton, E. S., Castorino, K., & Tate, D. F. (2016) · Diabetes Care · doi:10.2337/dc16-1728 · Cited by 2,991 · see citing works
Physiological adaptations to low-volume, high-intensity interval training in health and disease
Gibala, M. J., Little, J. P., MacDonald, M. J., & Hawley, J. A. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.224725 · Cited by 1,744 · see citing works
Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli
Green, D. J., Hopman, M. T. E., Padilla, J., Laughlin, M. H., & Thijssen, D. H. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00014.2016 · Cited by 821 · see citing works
de Zeeuw, D., Remuzzi, G., Parving, H., Keane, W. F., Zhang, Z., Shahinfar, S., Snapinn, S., Cooper, M. E., Mitch, W. E., & Brenner, B. M. (2004) · Circulation · doi:10.1161/01.cir.0000139860.33974.28 · Cited by 748 · see citing works
Jelleyman, C., Yates, T., O'Donovan, G., Gray, L. J., King, J. A., Khunti, K., & Davies, M. J. (2015) · Obesity Reviews · doi:10.1111/obr.12317 · Cited by 588 · see citing works
The role of leptin/adiponectin ratio in metabolic syndrome and diabetes
López-Jaramillo, P., Gómez-Arbeláez, D., López-López, J., López-López, C., Martínez-Ortega, J., Gómez-Rodríguez, A., & Triana-Cubillos, S. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0053 · Cited by 405 · see citing works
Perivascular adipose tissue inflammation in vascular disease
Nosalski, R., & Guzik, T. J. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13705 · Cited by 399 · see citing works
Karstoft, K., Winding, K., Knudsen, S. H., Nielsen, J. S., Thomsen, C., Pedersen, B. K., & Solomon, T. P. J. (2013) · Diabetes Care · doi:10.2337/dc12-0658 · Cited by 339 · see citing works
Mitranun, W., Deerochanawong, C., Tanaka, H., & Suksom, D. (2013) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12112 · Cited by 329 · see citing works
Leptin, cardiovascular diseases and type 2 diabetes mellitus
Katsiki, N., Mikhailidis, D. P., & Banach, M. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2018.40 · Cited by 286 · see citing works
Effects of Physical Activity on Cardiovascular Disease
Ahmed, H. M., Blaha, M. J., Nasir, K., Rivera, J. J., & Blumenthal, R. S. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.08.042 · Cited by 253 · see citing works
Bradbury, K. E., Guo, W., Cairns, B. J., Armstrong, M. E. G., & Key, T. J. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-011843 · Cited by 173 · see citing works
High-Normal Albuminuria and Risk of Heart Failure in the Community
Blecker, S., Matsushita, K., Köttgen, A., Loehr, L. R., Bertoni, A. G., Boulware, L. E., & Coresh, J. (2011) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2011.02.391 · Cited by 148 · see citing works
Higher Levels of Albuminuria within the Normal Range Predict Incident Hypertension
Forman, J. P., Fisher, N. D. L., Schopick, E. L., & Curhan, G. C. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008010038 · Cited by 127 · see citing works
Becic, T., Studenik, C., & Hoffmann, G. (2018) · Medical Sciences · doi:10.3390/medsci6040097 · Cited by 127 · see citing works
Tikkanen-Dolenc, H., Wadén, J., Forsblom, C., Harjutsalo, V., Thorn, L. M., Saraheimo, M., Elonen, N., Tikkanen, H. O., & Groop, P.-H. (2017) · Diabetes Care · doi:10.2337/dc17-0615 · Cited by 93 · see citing works
Randomized Controlled Trial of Exercise in CKD—The RENEXC Study
Hellberg, M., Höglund, P., Svensson, P., & Clyne, N. (2019) · Kidney International Reports · doi:10.1016/j.ekir.2019.04.001 · Cited by 82 · see citing works
Pai, L.-W., Li, T.-C., Hwu, Y.-J., Chang, S.-C., Chen, L.-L., & Chang, P.-Y. (2016) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2016.01.011 · Cited by 80 · see citing works
Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results
Rovīte, V., Sagy, Y. W., Zaharenko, L., Ņikitina-Zaķe, L., Grens, E., & Kloviņš, J. (2018) · Journal of Epidemiology · doi:10.2188/jea.je20170079 · Cited by 80 · see citing works
Liang, W. H., & Ye, D. D. (2019) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2019.06.002 · Cited by 73 · see citing works
Kuziemski, K., Słomiński, W., & Jassem, E. (2019) · BMC Endocrine Disorders · doi:10.1186/s12902-018-0328-1 · Cited by 70 · see citing works
Morikawa, M., Okazaki, K., Masuki, S., Kamijo, Y., Yamazaki, T., Gen-no, H., & Nosé, H. (2009) · British Journal of Sports Medicine · doi:10.1136/bjsm.2009.064816 · Cited by 68 · see citing works
Kim, J. D., Kang, S. J., Lee, M. K., Park, S. E., Rhee, E., Park, C., Oh, K. W., Park, S. W., & Lee, W. (2016) · Endocrinology and Metabolism · doi:10.3803/enm.2016.31.2.320 · Cited by 67 · see citing works
Lim, C. C., Teo, B. W., Tai, E. S., Lim, S. C., Chan, C. M., Sethi, S. K., Wong, T. Y., & Sabanayagam, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122009 · Cited by 64 · see citing works
Chang, A. M., Smith, M. J., Bloem, C. J., Gałecki, A. T., Halter, J. B., & Supiano, M. A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1803 · Cited by 64 · see citing works
Rodríguez, A. J., Nogueira, V. D. S. N., Mastronardi, C. A., Neeman, T. M., & Paz-Filho, G. (2015) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2015.11.004 · Cited by 63 · see citing works
Exercise training improves vascular function in adolescents with type 2 diabetes
Naylor, L. H., Davis, E. A., Kalic, R. J., Paramalingam, N., Abraham, M. B., Jones, T. W., & GREEN, D. J. (2016) · Physiological Reports · doi:10.14814/phy2.12713 · Cited by 54 · see citing works
Leptin Sensitivity in Skeletal Muscle Is Modulated by Diet and Exercise
Dyck, D. J. (2005) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200510000-00007 · Cited by 53 · see citing works
Barlovič, D. P., Tikkanen-Dolenc, H., & Groop, P. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1157-y · Cited by 40 · see citing works
Lin, H.-C., Peng, C., Chiou, J., & Huang, C. (2014) · Primary care diabetes · doi:10.1016/j.pcd.2014.04.004 · Cited by 27 · see citing works
Vyssoulis, G. P., Karpanou, E. A., Spanos, P., Kyvelou, S.-M., Adamopoulos, D. N., & Stefanadis, C. (2010) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2010.00306.x · Cited by 17 · see citing works
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Cited by
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Ruilope, L. M., Ortíz, A., Lucía, A., Miranda, B., Álvarez‐Llamas, G., Barderas, M. G., Volpe, M., Ruiz‐Hurtado, G., & Pitt, B. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac683 · Cited by 111 · see citing works
García-Hermoso, A., Ramírez-Vélez, R., Díez, J., González, A., & Izquierdo, M. (2023) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2022.11.003 · Cited by 80 · see citing works
Hejazi, K., Rahimi, G. R. M., & Rosenkranz, S. K. (2022) · Biological Research For Nursing · doi:10.1177/10998004221132841 · Cited by 46 · see citing works
Versluis, A., Boels, A. M., Huijden, M. C. G., Mijnsbergen, M. D., Rutten, G. E. H. M., & Vos, R. C. (2025) · Diabetic Medicine · doi:10.1111/dme.70002 · Cited by 38 · see citing works
Physical exercise: a polypill against chronic kidney disease
Valenzuela, P. L., Castillo‐García, A., Saco‐Ledo, G., Santos‐Lozano, A., & Lucía, A. (2024) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfae062 · Cited by 31 · see citing works
Garcia, S. P., Cureau, F. V., Iorra, F. D. Q., Bottino, L. G., Monteiro, L. E. R. C., Leivas, G., Umpierre, D., & Schaan, B. D. (2025) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2025.112027 · Cited by 39 · see citing works
Waki, K., Nara, M., Enomoto, S., Mieno, M., Kanda, E., Sankoda, A., Kawai, Y., Miyake, K., Wakui, H., Tsurutani, Y., et al. (2024) · npj Digital Medicine · doi:10.1038/s41746-024-01114-8 · Cited by 24 · see citing works
Arrieta-Leandro, M. C., Moncada‐Jiménez, J., Morales-Scholz, M. G., & Hernández‐Elizondo, J. (2023) · Journal of Endocrinological Investigation · doi:10.1007/s40618-023-02144-x · Cited by 20 · see citing works
Khalafi, M., Maleki, A. H., Symonds, M. E., Alamdari, K. A., Ehsanifar, M., & Rosenkranz, S. K. (2025) · Obesity Reviews · doi:10.1111/obr.13954 · Cited by 16 · see citing works
Xue, H., Zhang, L., Shi, Y., Zhang, H., Zhang, C., Liu, Y., Tan, W., & Liu, Y. (2025) · Frontiers in Digital Health · doi:10.3389/fdgth.2025.1630588 · Cited by 15 · see citing works
Yan, L., Hu, X., Wu, S., Chen, L., & Zhao, S. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1353881 · Cited by 6 · see citing works
Yan, H., Zhuang, M., Liu, Q., Wan, X., Yin, M., Xu, K., Yang, Y., Zheng, H., Cao, C., Zheng, X., et al. (2026) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.70780 · Cited by 4 · see citing works
Users’ Expectations of Smart Devices during Physical Activity—A Literature Review
Tóth, K., Takács, P., & Balatoni, I. (2024) · Applied Sciences · doi:10.3390/app14083518 · Cited by 3 · see citing works
Stirane, L., Юрисович, С. К., Pahirko, L., Mednieks, J., Ostrovska, K., Kļaviņa, A., Selavo, L., & Sokolovska, J. (2025) · Physiological Reports · doi:10.14814/phy2.70476 · Cited by 1 · see citing works
Self-citationGallardo‐Gómez, D., Alfonso‐Rosa, R. M., Ramos-Munell, J., del Pozo-Cruz, J., Cruz, B. D. P., & Álvarez‐Barbosa, F. (2024) · doi:10.2337/figshare.24001908.v1 · Cited by 1 · see citing works
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Fitri, N., Dewi, Y. S., Suarilah, I., Efendi, C., & Yazid, S. A. (2024) · Nurse and Health Jurnal Keperawatan · doi:10.36720/nhjk.v13i2.672 · Cited by 2 · see citing works
Vieira, J. M., Carvalho, V. O., Aguiar, L. A., Smart, N. A., Monteiro, C. N., Weege, M. H., da Silva, R. P., RANGEL, B., & Gomes-Neto, M. (2026) · Clinical Rehabilitation · doi:10.1177/02692155261416862
Wearable Gait Assessment for Diabetes: A Systematic Survey
Amarak, A., Valero, M., & Nino, V. (2026) · Applied Sciences · doi:10.3390/app16062956
Mudjanarko, S. W., Irawati, A., Leoni, J., & Tinduh, D. (2026) · Biomedical Human Kinetics · doi:10.2478/bhk-2026-0012
Gohardehi, F., Ghanami, B., Silakhor, M., & Sobhanian, P. (2026) · Health Science Reports · doi:10.1002/hsr2.72116
Xu, J., Luo, S., & Gao, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1825473
- Authors
- Sokolovska, J., Ostrovska, K., Pahirko, L., Varblane, G., Krilatiha, K., Cirulnieks, A., Folkmane, I., Pirags, V., Valeinis, J., Klavina, A., & Selavo, L.
- Affiliations
- Faculty of Medicine University of Latvia Riga Latvia
- Latvian Academy of Sport Education (LV)
- University of Latvia (LV)
- Pauls Stradiņš Clinical University Hospital (LV)
- Faculty of Physics, Mathematics and Optometry University of Latvia Riga Latvia
- Latvian Academy of Sport Education Riga Latvia
- Venue
- Physiological Reports
- Publisher
- Wiley
- Published
- 2020-07
- Volume
- 8
- Issue
- 13
- Pages
- e14506-e14506
- ISSN
- 2051-817X (ISSN-L)
- PMC
- PMC7354089
- OpenAlex
- W3041323401
- Cited by
- 21
- References
- 32
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 6 · 2023: 1 · 2022: 3
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Physiological Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Latvijas Universitate
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Keywords
- type 2 diabetes, albuminuria, leptin/adiponectin ratio, mobile application, glycemic control, HbA1c, obesity, hip circumference, vascular health, exercise intervention
- MeSH terms
- Smartphone, Adult, Aged, Albuminuria, Diabetes Mellitus, Type 2, Exercise Therapy, Female, Humans, Male, Middle Aged, Walking, Leptin, Adiponectin, Mobile Applications
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