Physiological adaptations to low-volume, high-intensity interval training in health and disease

Gibala, Martin J.; Little, Jonathan P.; MacDonald, Maureen J.; Hawley, John A.

doi:10.1113/jphysiol.2011.224725

Cited by 1,744Cardiovascular and exercise physiologySports Performance and TrainingPhysical Activity and Health

Physiological adaptations to low-volume, high-intensity interval training in health and disease

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Gibala, Martin J., Little, Jonathan P., MacDonald, Maureen J., Hawley, John A.·2012·The Journal of Physiology

DOI 10.1113/jphysiol.2011.224725PMC PMC3381816

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Abstract

Abstract Exercise training is a clinically proven, cost‐effective, primary intervention that delays and in many cases prevents the health burdens associated with many chronic diseases. However, the precise type and dose of exercise needed to accrue health benefits is a contentious issue with no clear consensus recommendations for the prevention of inactivity‐related disorders and chronic diseases. A growing body of evidence demonstrates that high‐intensity interval training (HIT) can serve as an effective alternate to traditional endurance‐based training, inducing similar or even superior physiological adaptations in healthy individuals and diseased populations, at least when compared on a matched‐work basis. While less well studied, low‐volume HIT can also stimulate physiological remodelling comparable to moderate‐intensity continuous training despite a substantially lower time commitment and reduced total exercise volume. Such findings are important given that ‘lack of time’ remains the most commonly cited barrier to regular exercise participation. Here we review some of the mechanisms responsible for improved skeletal muscle metabolic control and changes in cardiovascular function in response to low‐volume HIT. We also consider the limited evidence regarding the potential application of HIT to people with, or at risk for, cardiometabolic disorders including type 2 diabetes. Finally, we provide insight on the utility of low‐volume HIT for improving performance in athletes and highlight suggestions for future research.

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HIIT can reduce learning decline in the Morris water maze test in rats with AD.
“At the behavioral level, it has been shown that HIIT can reduce learning decline in the Morris water maze test in rats with AD (28,29).”
From Effects of the combination of high-intensity interval training and Ecdysterone on learning and memory abilities, antioxidant enzyme activities, and neuronal population in an Amyloid-beta-induced rat model of Alzheimer’s disease (2022) · cites this paper as [28]
HIIT is an effective and time-efficient exercise option for improving cardiometabolic health.
“HIIT has recently been touted as an effective and time-efficient exercise option for improving cardiometabolic health [18, 37].”
From High-Intensity Interval Training as an Efficacious Alternative to Moderate-Intensity Continuous Training for Adults with Prediabetes (2015) · cites this paper as [18]

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HIIT trening i prehrana
Holjevac, K. (2020)

Authors: Gibala, M. J., Little, J. P., MacDonald, M. J., & Hawley, J. A.
Affiliations: McMaster University (CA)
University of British Columbia, Okanagan Campus (CA)
RMIT University (AU)
ORCID: Gibala, Martin J.
Little, Jonathan P.
MacDonald, Maureen J.
Hawley, John A.
Venue: The Journal of Physiology
Publisher: Wiley
Published: 2012-03
Volume: 590
Issue: 5
Pages: 1077-1084
ISSN: 0022-3751 (ISSN-L)
1469-7793
DOI: 10.1113/jphysiol.2011.224725
PMC: PMC3381816
OpenAlex: W2134334767
Semantic Scholar: 02c92e58b0118caebc7733963f25a5b11d991b6d
Cited by: 1,744
References: 48
Citations by year: 2026: 100 · 2025: 118 · 2024: 118 · 2023: 98 · 2022: 138 · 2021: 143 · 2020: 181 · 2019: 149 · 2018: 165 · 2017: 116 · 2016: 105 · 2015: 149 · 2014: 83 · 2013: 61 · 2012: 18
FWCI: 23.17
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research Bank (Australian Catholic University) (submittedVersion)
RMIT Research Repository (RMIT University Library) (submittedVersion)
Figshare (submittedVersion, cc-by)
Funders: Canadian Diabetes Association
McMaster University
Canadian Institutes of Health Research
Natural Sciences and Engineering Research Council of Canada
Australian Research Council
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords: high-intensity interval training, physiological adaptation, skeletal muscle metabolism, cardiovascular function, cardiometabolic disease, type 2 diabetes, exercise dose, barriers to exercise, athletic performance, chronic disease prevention
MeSH terms: Adaptation, Physiological, Cardiovascular Diseases, Humans, Exercise, Athletic Performance

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Physiological adaptations to low-volume, high-intensity interval training in health and disease

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