Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial
Open accessAbstract
BACKGROUND: Physical function and exercise capacity decline with age and are a major source of disability in older people. Recent evidence suggests a potential role for the renin-angiotensin system in modulating muscle function. We sought to examine the effect of the angiotensin-converting-enzyme (ACE) inhibitor perindopril on physical function in elderly people with functional impairment who had no heart failure or left ventricular systolic dysfunction. METHODS: In this double-blind randomized controlled trial, participants aged 65 years and older who had problems with mobility or functional impairment were randomly assigned to receive either perindopril or placebo for 20 weeks. The primary outcome was the change in the 6-minute walking distance over the 20 weeks. Secondary outcomes were changes in muscle function, daily activity levels, self-reported function and health-related quality of life. RESULTS: A total of 130 participants were enrolled in the study (mean age 78.7, standard deviation 7.7 years); 95 completed the trial. At 20 weeks, the mean 6-minute walking distance was significantly improved in the perindopril group relative to the placebo group (mean between-group difference 31.4 m, 95% confidence interval [CI] 10.8 to 51.9 m; p = 0.003). There was a significant impact on health-related quality of life: although the mean score for part 1 of the EQ-5D questionnaire deteriorated over time in the placebo group, quality of life was maintained in the perindopril group, for a between-group difference of 0.09 (p = 0.046). There were no significant differences between the 2 groups in the other outcomes. INTERPRETATION: Use of the ACE inhibitor perindopril improved exercise capacity in functionally impaired elderly people who had no heart failure and maintained health-related quality of life. The degree of improvement was equivalent to that reported after 6 months of exercise training. (International Standard Randomised Controlled Trial Register no. ISRCTN67679521).
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IGF-1 does not appear to improve muscle strength or bone density in healthy older women.
“IGF-1 does not appear to improve muscle strength or bone density in healthy older women (132).”
From Frailty in elderly people (2013) · cites this paper as [132]
Among 95 participants who completed a 20-week trial, the mean 6-min walking test was significantly improved in subjects receiving perindopril relative to the placebo group (mean between-group difference 31 m).
“Among 95 participants that completed a 20-week trial, the mean 6-min walking test was significantly improved in subjects receiving perindopril relative to the placebo group (mean betweengroup difference 31 m) [127]”
From Is There Enough Evidence for Osteosarcopenic Obesity as a Distinct Entity? A Critical Literature Review (2019) · cites this paper as [127]
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- Authors
- Sumukadas, D., Witham, M. D., Struthers, A. D., & McMurdo, M. E. T.
- Affiliations
- University of Dundee (GB)
- Venue
- Canadian Medical Association Journal
- Publisher
- CMA Joule Inc.
- Published
- 2007-10-09
- Volume
- 177
- Issue
- 8
- Pages
- 867-874
- ISSN
- 0820-3946 (ISSN-L)
- 1488-2329
- PMC
- PMC1995143
- OpenAlex
- W2117980765
- Cited by
- 246
- References
- 41
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 10 · 2023: 9 · 2022: 13 · 2021: 14 · 2020: 16 · 2019: 13 · 2018: 16 · 2017: 18 · 2016: 21 · 2015: 15 · 2014: 20 · 2013: 22 · 2012: 10
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Canadian Medical Association Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Funders
- Servier
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- perindopril, ACE inhibitors, physical function, functional disability, older adults, exercise capacity, 6-minute walk test, health-related quality of life, renin-angiotensin system, mobility (physical function), muscle function
- MeSH terms
- Aged, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Creatinine, Diastole, Double-Blind Method, Exercise Test, Female, Humans, Male, Potassium, Prospective Studies, Quality of Life, Surveys and Questionnaires, Systole, Urea, Walking, Exercise Tolerance, Perindopril, Mobility Limitation
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