Pharmacological treatment of frailty in the elderly

Campbell, Stephen; Szoeke, Cassandra

doi:10.1002/j.2055-2335.2009.tb00440.x

Cited by 13Frailty in Older AdultsNutrition and Health in AgingPharmaceutical Practices and Patient Outcomes

Pharmacological treatment of frailty in the elderly

Campbell, Stephen, Szoeke, Cassandra·2009·Journal of Pharmacy Practice and Research

DOI 10.1002/j.2055-2335.2009.tb00440.x

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Abstract

The geriatric frailty syndrome can be characterised by a loss of physiological reserve in a variety of organ systems and an independent association with disability and mortality. The high cost of this condition in terms of decreased quality of life and an increased need for medical and personal care makes it an important focus for the development of effective pharmacological treatments. Several of these treatments have been trialled and have focused on the decreased levels of catabolic hormones seen in advancing age. Despite some improvement in muscle and tissue bulk, most of these treatments have failed to improve physical function in the elderly. In this review we examine the evidence for the pharmacological treatment of frailty in the elderly and provide recommendations for its management.

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Although frail older adults' muscles seem able to respond to IGF-1, supplementation trials in older people have not shown benefit.
“although the muscles of frail older people appear to retain the capability to respond to IGF-1 (42) trials of IGF-1 supplementation in older people have failed to demonstrate benefit (43).”
From Frailty in elderly people (2013) · cites this paper as [43]
The general use of vitamin D as treatment for frailty remains controversial.
“the general use of vitamin D as treatment for frailty remains controversial (43).”
From Frailty in elderly people (2013) · cites this paper as [43]

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Authors: Campbell, S., & Szoeke, C.
Affiliations: Austin Health (AU)
Commonwealth Scientific and Industrial Research Organisation (AU)
ORCID: Szoeke, Cassandra
Venue: Journal of Pharmacy Practice and Research
Publisher: Wiley
Published: 2009-06
Volume: 39
Issue: 2
Pages: 147-151
ISSN: 0310-6810 (ISSN-L)
1445-937X
2055-2335
DOI: 10.1002/j.2055-2335.2009.tb00440.x
OpenAlex: W2141668666
Cited by: 13
References: 73
Citations by year: 2026: 1 · 2024: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 3 · 2014: 2 · 2013: 1
FWCI: 0.00
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Pharmacy Practice and Research (publishedVersion)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Keywords: frailty, pharmacotherapy, older adults, geriatric syndromes, physiological reserve, catabolic hormones, muscle mass, physical function, disability, mortality, quality of life

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Pharmacological treatment of frailty in the elderly

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