The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Association between frailty and short- and long-term outcomes among critically ill patients: a multicentre prospective cohort study
Open accessAbstract
BACKGROUND: Frailty is a multidimensional syndrome characterized by loss of physiologic and cognitive reserves that confers vulnerability to adverse outcomes. We determined the prevalence, correlates and outcomes associated with frailty among adults admitted to intensive care. METHODS: We prospectively enrolled 421 critically ill adults aged 50 or more at 6 hospitals across the province of Alberta. The primary exposure was frailty, defined by a score greater than 4 on the Clinical Frailty Scale. The primary outcome measure was in-hospital mortality. Secondary outcome measures included adverse events, 1-year mortality and quality of life. RESULTS: The prevalence of frailty was 32.8% (95% confidence interval [CI] 28.3%-37.5%). Frail patients were older, were more likely to be female, and had more comorbidities and greater functional dependence than those who were not frail. In-hospital mortality was higher among frail patients than among non-frail patients (32% v. 16%; adjusted odds ratio [OR] 1.81, 95% CI 1.09-3.01) and remained higher at 1 year (48% v. 25%; adjusted hazard ratio 1.82, 95% CI 1.28-2.60). Major adverse events were more common among frail patients (39% v. 29%; OR 1.54, 95% CI 1.01-2.37). Compared with nonfrail survivors, frail survivors were more likely to become functionally dependent (71% v. 52%; OR 2.25, 95% CI 1.03-4.89), had significantly lower quality of life and were more often readmitted to hospital (56% v. 39%; OR 1.98, 95% CI 1.22-3.23) in the 12 months following enrolment. INTERPRETATION: Frailty was common among critically ill adults aged 50 and older and identified a population at increased risk of adverse events, morbidity and mortality. Diagnosis of frailty could improve prognostication and identify a vulnerable population that might benefit from follow-up and intervention.
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The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis
Muscedere, J., Waters, B., Varambally, A., Bagshaw, S. M., Boyd, J. G., Maslove, D., Sibley, S., & Rockwood, K. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4867-0 · Cited by 827
Self-citationHermans, G., Van Mechelen, H., Clerckx, B., Vanhullebusch, T., Mesotten, D., Wilmer, A., Casaer, M. P., Meersseman, P., Debaveye, Y., Van Cromphaut, S., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201312-2257oc · Cited by 533
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Screening for frailty in Canada’s health care system: A time for action
Muscedere, J., Andrew, M. K., Bagshaw, S. M., Estabrooks, C., Hogan, D., Holroyd-Leduc, J., Howlett, S., Lahey, W., Maxwell, C., McNally, M., et al. (2016) · Canadian Journal on Aging / La Revue canadienne du vieillissement · doi:10.1017/s0714980816000301 · Cited by 112
Mortality in Relation to Frailty in Patients Admitted to a Specialized Geriatric Intensive Care Unit
Zeng, A., Song, X., Dong, J., Mitnitski, A., Liu, J., Guo, Z., & Rockwood, K. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv084 · Cited by 96
Metadata
- Authors
- Bagshaw, S. M., Stelfox, H. T., McDermid, R. C., Rolfson, D. B., Tsuyuki, R. T., Baig, N., Artiuch, B., Ibrahim, Q., Stollery, D. E., Rokosh, E., & Majumdar, S. R.
- Venue
- Canadian Medical Association Journal
- Publisher
- CMA Joule Inc.
- Published
- 2013-11-25
- Volume
- 186
- Issue
- 2
- Pages
- E95-E102
- ISSN
- 0820-3946 (ISSN-L)
- 1488-2329
- OpenAlex
- W2152378282
- Cited by
- 555
- References
- 43
- FWCI
- 12.27
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bagshaw, S. M., Stelfox, H. T., McDermid, R. C., Rolfson, D. B., Tsuyuki, R. T., Baig, N., Artiuch, B., Ibrahim, Q., Stollery, D. E., Rokosh, E., & Majumdar, S. R. (2014). Association between frailty and short- and long-term outcomes among critically ill patients: a multicentre prospective cohort study. Canadian Medical Association Journal. https://doi.org/10.1503/cmaj.130639
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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