Cited by 707Opioid Use Disorder TreatmentPain Management and Opioid UseAnesthesia and Pain Management

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Guideline for opioid therapy and chronic noncancer pain

Open access

Busse, Jason W., Craigie, Samantha, Juurlink, David N., Buckley, D. Norman, Wang, Li, Couban, Rachel J., Agoritsas, Thomas, Akl, Elie A., Carrasco-Labra, Alonso, Cooper, Lynn, Cull, Chris, da Costa, Bruno R., Frank, Joseph W., Grant, Gus, Iorio, Alfonso, Persaud, Navindra, Stern, Sol, Tugwell, Peter, Vandvik, Per Olav, Guyatt, Gordon H.·2017·Canadian Medical Association Journal

DOI 10.1503/cmaj.170363PMC PMC5422149

Open this paper in CoChat — free account Open PDF

Abstract

Chronic noncancer pain includes any painful condition that persists for at least three months and is not associated with malignant disease.[1][1] According to seven national surveys conducted between 1994 and 2008, 15%–19% of Canadian adults live with chronic noncancer pain.[2][2] Chronic

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1503/cmaj.170363

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39489.470347.ad · Cited by 23,305
Self-citation
CDC Guideline for Prescribing Opioids for Chronic Pain—United States, 2016
Dowell, D., Haegerich, T. M., & Chou, R. (2016) · JAMA · doi:10.1001/jama.2016.1464 · Cited by 5,161
CDC Guideline for Prescribing Opioids for Chronic Pain — United States, 2016
Dowell, D., Haegerich, T. M., & Chou, R. (2016) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr6501e1 · Cited by 2,697
Going from evidence to recommendations
Guyatt, G. H., Oxman, A. D., Kunz, R., Falck-Ytter, Y., Vist, G. E., Liberati, A., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39493.646875.ae · Cited by 1,810
Self-citation
GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations
Andrews, J., Guyatt, G., Oxman, A. D., Alderson, P., Dahm, P., Falck-Ytter, Y., Nasser, M., Meerpohl, J., Post, P. N., Kunz, R., et al. (2013) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2012.03.013 · Cited by 1,416
Self-citation
GRADE guidelines: 15. Going from evidence to recommendation—determinants of a recommendation's direction and strength
Andrews, J. C., Schünemann, H. J., Oxman, A. D., Pottie, K. C., Meerpohl, J. J., Alonso‐Coello, P., Rind, D. M., Montori, V. M., Brito, J. P., Norris, S. L., et al. (2013) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2013.02.003 · Cited by 1,366
Self-citation
Opioid Prescriptions for Chronic Pain and Overdose
Dunn, K. M., Saunders, K. W., Rutter, C. M., Banta‐Green, C. J., Merrill, J. O., Sullivan, M. D., Weisner, C. M., Silverberg, M. J., Campbell, C. I., Psaty, B. M., et al. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-2-201001190-00006 · Cited by 1,265
Users' guides to the medical literature : a manual for evidence-based clinical practice
Guyatt, G. H., Rennie, D., Meade, M. O., & Cook, D. J. (2002) · Cited by 1,196
Self-citation
A synthesis of oral morphine equivalents (OME) for opioid utilisation studies
Nielsen, S., Degenhardt, L. J., Hoban, B., & Gisev, N. (2015) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3945 · Cited by 617
CDC Guideline for Prescribing Opioids for Chronic Pain — United States, 2016
Dowell, D., Haegerich, T. M., & Chou, R. (2016) · MMWR Recommendations and Reports · doi:10.15585/mmwr.rr6501e1er · Cited by 549

Flagged first, then by citations

Show all 50 references

Research works printed but not linked: 3

Merskey H, Bogduk N; Task Force on Taxonomy of the International Associa- tion for the Study of Pain. Classification of chronic pain, second edition (revised). Seattle (WA): International Association for the Study of Pain; 1994.
New York City Department of Health and Mental Hygiene. Preventing misuse of prescription opioid drugs. City Health Information 2011;30:23-30.
College endorses the US Centers for Disease Control and Prevention's guide- lines for prescribing opioids for chronic pain [media release]. Halifax (NS): Col- lege of Physicians & Surgeons of Nova Scotia; 2016. Available: www.cpsns.ns. ca/News/Press-Releases/Details/ArticleId/266/College-Endorses-CDC-Guidelines -for-Prescribing-Opioids-for-Chronic-Pain (accessed 2017 Mar. 11).

Sorted by citations

Items 401–500 of 707

Role of Rehabilitation in Opioid Tapering: A Scoping Review
Wiens, M., Jarrett, D., Settimi, A., White, C., Hollingham, Z., & Packham, T. (2021) · Physiotherapy Canada · doi:10.3138/ptc-2020-0011 · Cited by 4
Post‐injury benzodiazepine and opioid use among older adults involved in road traffic crashes: A Swedish register‐based longitudinal study
Duchesne, J., Laflamme, L., Lu, L., Lagarde, E., & Möller, J. (2021) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.15019 · Cited by 4
“Number of days before the first opioid dispensation (median [Q1-Q3]) 9 (2-142) 4 (1-9) 176 (9-428) 22 (6-123)”
The association of gender and persistent opioid use following an acute pain event: A retrospective population based study of renal colic
Jaeger, M. T., Hosier, G., McGregor, T. B., Beiko, D. T., Kasasni, S. M., Booth, C. M., Whitehead, M., & Siemens, D. R. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256582 · Cited by 4
“The opioid crisis has serious social and economic repercussions leading to multiple countries declaring public health emergencies [7, 8].”
Background
Spinal Cord Stimulation as an Alternative to Opioid for Axial Neck and Back Pain: A Case Series
Mullins, G. S., Burns, J. J., Schneider, A. P., & Helou, A. E. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.847504 · Cited by 4
“This is particularly important in Canada, which has the second highest rate per capita of opioid prescription in the world with an increased prevalence of use, and current guidelines recommend specific criteria for initiation of opioids for chronic non-cancer pain (14).”
Background
Opioid-induced respiratory depression and risk factors in a tertiary hospital: A retrospective study
Almouaalamy, N. A., Alshamrani, M. A., Alnejadi, W. K., Alharbi, Z., Aldosari, F. M., Alsulimani, E. F., Saif, S. A., & Aldawsari, M. K. (2022) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2022.06.004 · Cited by 4
A retrospective analysis of pain changes and opioid use patterns temporally associated with a course of chiropractic care at a publicly funded inner-city facility.
Passmore, S. R., Malone, Q., Manansala, C., Ferbers, S., Toth, E. A., & Olin, G. (2022) · PubMed Central · Cited by 4
Nonopioid Analgesic Prescriptions Filled after Surgery among Older Adults in Ontario, Canada: A Population-based Cohort Study
Jivraj, N. K., Ladha, K. S., Goel, A., Hill, A. D., Wijeysundera, D. N., Bateman, B. T., Neuman, M. D., & Wunsch, H. (2022) · Anesthesiology · doi:10.1097/aln.0000000000004443 · Cited by 4
“Secondarily, we also evaluated drugs that are primarily used in the management of chronic pain together as a single category, including (1) tricyclic antidepressants, including amitriptyline and nortriptyline; (2) serotonin norepinephrine reuptake inhibitors (venlafaxine and duloxetine); (3) muscle relaxants (cycloben…”
BackgroundMethodInfluential
Effect of a Veterans Health Administration mandate to case review patients with opioid prescriptions on mortality among patients with opioid use disorder: a secondary analysis of the STORM randomized control trial
Auty, S. G., Barr, K. D., Frakt, A. B., Garrido, M. M., & Strombotne, K. L. (2022) · Addiction · doi:10.1111/add.16110 · Cited by 4
Effectiveness of Audit and Feedback and Academic Detailing Interventions to Support Safer Opioid Prescribing in Primary Care
Lacroix, M., Abdelmalek, F., Everett, K., Taljaard, M., Salach, L., Bevan, L., Burton, V., Jia, H., Shuldiner, J., Laur, C. V., et al. (2024) · The American Journal of Medicine · doi:10.1016/j.amjmed.2024.09.017 · Cited by 4
Uso problemático de los analgésicos opioides de prescripción: clasificación y tratamientos eficaces
Ruiz, A. I. H. (2018) · Medicina Clínica · doi:10.1016/j.medcli.2018.10.008 · Cited by 4
The Relationship between Higher Chronic Opioid Therapy Dose and Specific Personality Traits in Individuals with Chronic Pain
McIntyre, A., Mehta, S., Vanderlaan, D., Sequeira, K., Loh, E., & Teasell, R. W. (2021) · Pain Research and Management · doi:10.1155/2021/9946067 · Cited by 4
“(e 2017 Guideline on Opioid (erapy for Chronic Noncancer Pain [10] suggests that physicians limit opioid analgesic dosing when beginning opioid therapy to no more than 90mg morphine equivalent dose.”
Background
Simple screening model for identifying the risk of sleep apnea in patients on opioids for chronic pain
Selvanathan, J., Waseem, R., Peng, P., Wong, J., Ryan, C. M., & Chung, F. F. (2021) · Regional Anesthesia & Pain Medicine · doi:10.1136/rapm-2020-102388 · Cited by 4
Lies and convictions at Aulis
Burgess, D. L. (2004) · Cited by 4
Characteristics and Incidence of Opioid Analgesic Initiations to Opioid Naïve Patients in a Canadian Primary Care Setting
Klimas, J., Hamilton, M., Carney, G., Cooper, I., Croteau, N., Dong, H.-R., Dormuth, C., Maclure, M., Socías, M., Ti, L., et al. (2022) · Canadian Journal of Addiction · doi:10.1097/cxa.0000000000000135 · Cited by 2
“1 monthly initiation incidence remains relatively stable, despite recent efforts to address the broader opioid overdose epidemic and new guidelines on opioid therapy and chronic non-cancer pain.(36,37) While Fraser region has the most opioid analgesic initiations, their relative prescriptions per inhabitants appear le…”
Background
A decade of extreme oscillations in opioid control and availability: implications for public health in a Canadian setting
Fischer, B., & Wood, E. (2020) · Journal of Public Health Policy · doi:10.1057/s41271-019-00214-0 · Cited by 4
The authors respond to “The 2017 Canadian opioid guideline: already time for an overhaul”
Busse, J. W., Juurlink, D. N., Buckley, D. N., & Guyatt, G. H. (2018) · Canadian Medical Association Journal · doi:10.1503/cmaj.68675 · Cited by 4
Self-citation
Medical nutrition therapy for chronic pain management
Glenn, A. J., Kavanagh, M. E., Bockus-Thorne, L., McNeill, L., Melina, V., Jenkins, D. J. A., & Grant, S. (2022) · Wiley eBooks · doi:10.1002/9781119701170.ch14 · Cited by 4
Cannabinoids for Pain Modulation in Orthopedic Surgery
Chin, G., Etiz, B. A. F., Nelson, A. M., Lim, P. K., & Scolaro, J. A. (2022) · Orthopedics · doi:10.3928/01477447-20220706-03 · Cited by 3
Income-Based Disparities in Opioid Prescription Dispensing Among Public Drug Plan Beneficiaries in Canada from 2010 to 2018: A Population-Based and Sex-Stratified Retrospective Study
Alsabbagh, M. W., Alsefaou, M., Elliott, S. J., Cooke, M. J., & Chang, F. (2025) · Drugs - Real World Outcomes · doi:10.1007/s40801-025-00498-7 · Cited by 3
“Opioids and related medications, along with their Anatomical Therapeutic Chemical (ATC) codes and morphine milligram equivalent (MME) conversion rates [18, 50], that were included in this study are available in Table 1.”
The (Hypothetical) Scenario of a Fentanyl-Overdose Death Epidemic in Europe: Considering Canada-Based Experiences and Insights
Fischer, B., Jutras‐Aswad, D., Foll, B. L., & Robinson, T. (2025) · SUCHT - Zeitschrift für Wissenschaft und Praxis / Journal of Addiction Research and Practice · doi:10.1024/0939-5911/a000930 · Cited by 3
Constructing Opioid Legitimacy: The Canadian Pain Task Force’s Framing of the Overdose Crisis
Klein, D. E., Grundy, Q., Hawkins, B., & Schwartz, R. M. (2025) · The Journal of Law Medicine & Ethics · doi:10.1017/jme.2025.10158 · Cited by 3
Response to the Comment on “Postoperative Opioid Prescribing and Pain”
Pagé, M. G., Clarke, H. A., & Kudrina, I. (2019) · Annals of Surgery · doi:10.1097/sla.0000000000003653 · Cited by 3
“In the interest of patient safety and public health, it is important to have valid data on postoperative opioid prescribing, and postoperative use, and the reasons for that use, and to reduce post-discharge opioid over-prescribing, while also paramount to not impair the appropriate treatment of postoperative pain.(2,6…”
Background
Trends in opioid use before critical illness among elderly patients in Ontario
Wang, H. T., Hill, A. D., Gomes, T., Pinto, R. L., Wijeysundera, D. N., Scales, D. C., Fowler, R., & Wunsch, H. (2019) · Journal of Critical Care · doi:10.1016/j.jcrc.2019.10.004 · Cited by 3
Prescribing patterns of opioids and adjunctive analgesics for patients with burn injuries
Yeung, C., Kiss, A., Rehou, S., & Shahrokhi, S. (2020) · Burns · doi:10.1016/j.burns.2020.09.009 · Cited by 3
Emergency physician risk assessment practices prior to prescribing opioids
McKinney, M., Kisilewicz, M., & Stiell, I. G. (2021) · Canadian Journal of Emergency Medicine · doi:10.1007/s43678-020-00066-8 · Cited by 3
Tips and tools for safe opioid prescribing
Linn (2020) · The Journal of Family Practice · doi:10.12788/jfp.0019 · Cited by 3
Postoperative duration of opioid use and acute healthcare services use in cancer patients hospitalized for thoracic surgery
Kurteva, S., Tamblyn, R. M., Khosrow‐Khavar, F., & Meguerditchian, A. N. (2021) · Journal of Surgical Oncology · doi:10.1002/jso.26504 · Cited by 3
Hub-and-Spoke Models of Care for Chronic Pain
Barbara, A. M., & MacDougall, D. (2022) · Canadian Journal of Health Technologies · doi:10.51731/cjht.2022.322 · Cited by 3
From ‘pain management’ to ‘integrated health clinic’: a quality improvement project to transition patients on chronic opioid therapy to more evidence-based therapies for chronic pain
Hill, E., Reich, D., & Ayeni, E. (2022) · BMJ Open Quality · doi:10.1136/bmjoq-2022-001852 · Cited by 3
Appropriate use of tapentadol: focus on the optimal tapering strategy
Vellucci, R., & Fornasari, D. (2022) · Current Medical Research and Opinion · doi:10.1080/03007995.2022.2148459 · Cited by 3
Chronic Pain: A Case Application of a Novel Framework to Guide Interprofessional Assessment and Intervention in Primary Care
Reaume, J. (2023) · Canadian Journal of Pain · doi:10.1080/24740527.2023.2228851 · Cited by 3
Opioid deprescribing in long-term care in Ontario: A comparison of resident and facility characteristics
Rochon, A., Almost, J., Li, W., Seitz, D. P., & Tranmer, J. E. (2023) · Geriatric Nursing · doi:10.1016/j.gerinurse.2023.06.024 · Cited by 3
Healthcare interactions and barriers to chronic pain management: A qualitative study of people who use drugs in Uyo, Nigeria
Nelson, E.-U. E., Akintunde, A. A., & Ojo, Y. A. (2023) · Cogent Social Sciences · doi:10.1080/23311886.2023.2228080 · Cited by 3
Trajectories of opioid consumption as predictors of patient‐reported outcomes among individuals attending multidisciplinary pain treatment clinics
Angarita-Fonseca, A., Lacasse, A., Choinière, M., Kaboré, J.-L., Sylvestre, M., Dinkou, G. D. T., Bruneau, J., Martel, M., Hovey, R., Motulsky, A., et al. (2023) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.5706 · Cited by 2
“…among individuals with CP. 13 Available clinical trials studies 14,15 are also typically of short follow-up duration or do not assess the harms of long-term opioid therapy, 11,16 such as opioid consumption for other reasons than pain, opioid diversion, opioid use disorder, and overdose deaths.”
Background
Shifting quality chronic pain treatment measures from processes to outcomes
Coleman, C., Lennon, R. P., Garza, R. H., Veasley, C., Kuchera, J., Edwards, R. R., & Zgierska, A. E. (2023) · Journal of Opioid Management · doi:10.5055/jom.2023.0802 · Cited by 2
Trends in the prescription of opioids and gabapentinoids in patients with failed back surgery syndrome in Korea: a population-based study
Oh, J., & Yeo, J. (2023) · The Korean journal of pain · doi:10.3344/kjp.23246 · Cited by 3
“Recent guidelines on long-term opioid treatment for non-cancer pain recommended restricting the dosage for long-term opioid therapy to 90–150 MED/day [31–33].”
Background
Exploring the Pain Situation, Pain Impact, and Educational Preferences of Pain Among Adults in Mainland China, a Cross-Sectional Study
He, J., Tse, M. Y. M., Kwok, T. T.-O., Wu, T. C. M., & Tang, S. (2025) · Healthcare · doi:10.3390/healthcare13030289 · Cited by 3
“However, the guidelines advise against medication use due to the heightened risk of adverse events associated with long-term opioid use [38,39].”
Pre-admission Opioid Use and Associated Outcomes in Patients Revascularised for Lower Peripheral Artery Disease
Petersen, J. K., Bager, L. G. V., Østergaard, L., Smolderen, K. G. E., Mena‐Hurtado, C., Resch, T. A., Eiberg, J., Køber, L., & Fosbøl, E. L. (2025) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2025.08.026 · Cited by 3
The Effects of a Multiday (10–14 days) Subanesthetic Dose IV Ketamine Infusion in the Treatment of Refractory Chronic Pain
Chebini, A., Marzoughi, S., Randhawa, J., Guh, D. P., Wiseman, S., Fedoroff, I. C., & Ong, M. (2021) · Pain Management · doi:10.2217/pmt-2021-0064 · Cited by 3
Management of cancer pain in pregnancy: can opioids be used?
Nafula, E. W., Weru, J. K., & Yennurajalingam, S. (2023) · Annals of Palliative Medicine · doi:10.21037/apm-23-74 · Cited by 3
Critiquing the CDC Opioid Guideline: Some Light From the Heat
Juurlink, D. N. (2018) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1061 · Cited by 3
“These concerns aside, the resulting recommendations mirror many of those in the 2017 Canadian guideline, which avoided these same limitations.(5) Another of Ballantyne et al.”
ResultSelf-citation
The six Rs of managing high-risk opioid prescribing
Armstrong, F., Arunogiri, S., Frei, M. Y., & Lubman, D. I. (2020) · Australian Journal of General Practice · doi:10.31128/ajgp-06-19-4967 · Cited by 3
Concordance between high antibiotic prescribing and high opioid prescribing among primary care physicians: a cross-sectional study
Langford, B. J., Chen, C., Daneman, N., Brown, K. A., Gomes, T., Johnstone, J., Wu, J. H., Leung, V., Garber, G. E., & Schwartz, K. L. (2021) · CMAJ Open · doi:10.9778/cmajo.20200122 · Cited by 3
“The 2017 Canadian Guideline for Opi-oids for Chronic Non-Cancer Pain 20 and the CDC [Centers for Disease Control and Prevention] Guideline for Prescribing Opioids for Chronic Pain — United States, 2016 21 recommend avoiding increasing dosages beyond 90 morphine milli-gram equivalents or carefully justifying any decisi…”
Influential
The effect of a methadone reformulation on opioid agonist treatment outcomes: A population-based study in British Columbia, Canada, 2013–14
Krebs, E., Hongdilokkul, N., Dale, L. M., Min, J. E., Schnepel, K., Shigeoka, H., & Nosyk, B. (2021) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2021.108714 · Cited by 3
Adverse effects of opioids for non-cancer pain
(2018) · Drug and Therapeutics Bulletin · doi:10.1136/dtb.2018.2.0583 · Cited by 3
“Recently updated guidelines on the management of CNCP have highlighted the risks associated with opioids and encouraged use of non-opioid drugs and nonpharmacologic therapy, rather than a trial of opioids.(3,4)”
Background
Adapting Pain and Opioid Prescribing Continuing Education to the Virtual Environment: Optimizing Program Factors While Navigating Context
Sud, A., Harris, M., & Hodgson, K. (2021) · Pain Medicine · doi:10.1093/pm/pnab211 · Cited by 3
Methodological Quality Assessment of Systematic Review or Meta-Analysis Using AMSTAR-2: the Long-Term Effectiveness or Efficacy of Opioids for Chronic Non-Cancer PainPreprint
Li, Q., Deng, K., Jiang, X., Tao, H., Liu, H., & Chen, J. (2019) · doi:10.21203/rs.2.12469/v1 · Cited by 3
Commentary on Hayes et al. (2020): The harms of opioid dose escalation in the management of chronic non‐cancer pain
Bahji, A. (2020) · Addiction · doi:10.1111/add.14965 · Cited by 3
Lignes directrices simplifiées de PEER sur la douleur chronique: Gestion de la douleur chronique lombaire, arthrosique et neuropathique en première ligne
Korownyk, C. S., Montgomery, L., Young, J., Moore, S., Singer, A. G., MacDougall, P., Darling, S., Ellis, K., Myers, J., Rochford, C., et al. (2022) · Canadian Family Physician · doi:10.46747/cfp.6803e63 · Cited by 2
Association between parental bipolar disorder and increased risk of exposure to prescription opioids for their offspring
Li, D.-J., Chen, M.-H., Bai, Y.-M., Tsai, S., Cheng, C.-M., Su, T.-P., Chen, T.-J., Yeh, T.-C., & Liang, C.-S. (2022) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-022-02360-5 · Cited by 2
“The Canadian Medical Association recommendation suggests that healthcare professionals should be conservative in prescribing opioids for subjects with mental disorder [44]; other studies suggest that non-pharmacological alternation, such as behavioral/psychosocial approaches, should be considered first [45].”
Background
Postsurgical Pain Risk Stratification to Enhance Pain Management Workflow in Adult Patients: Design, Implementation, and Pilot Evaluation
Görges, M., Sujan, J., West, N., Sreepada, R. S., Wood, M. D., Payne, B. A., Shetty, S., Gelinas, J. P., & Sutherland, A. M. (2024) · JMIR Perioperative Medicine · doi:10.2196/54926 · Cited by 3
“Therefore, the primary outcome used to evaluate the accuracy of the risk stratification was based on inpatient daily opioid use, using a threshold of >90 MME per day to indicate high opioid use, in line with the recommendations for opioid therapy and chronic noncancer pain [24].”
BackgroundMethodInfluential
Pain profiles and opioid consumption following joint replacement surgery: a prospective observational cohort study
Chin, R. L., Tierney, S., Srikandarajah, S., Hoydonckx, Y., Alomari, A., Alvares, D., Chan, V., & Bhatia, A. (2025) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-025-02910-w · Cited by 2
Social Determinants of Chronic Pain Management for People Who Use Drugs: An Ethics of Care Approach
Nelson, E.-U. E. (2025) · Nursing Inquiry · doi:10.1111/nin.70003 · Cited by 2
“This situation is worsened by low access to pharmaceutical opioids owing to guidelines that encourage physicians to discontinue or taper opioids for patients with a history of drug use (Busse et al. 2017).”
The effects of a provincial opioid prescribing standard on prescribing for pain in adults: an interrupted time-series analysis
Panagiotoglou, D., Peterson, S., Lavergne, M. R., Gomes, T., Chadha, R., Hawley, P. H., & McCracken, R. (2025) · Canadian Medical Association Journal · doi:10.1503/cmaj.250167 · Cited by 2
Challenges in pain management and opioid prescribing practices following traumatic injury: a focus group study with orthopedic surgeons and general practitioners
Finstad, J., Clausen, T., Røise, O., Rosseland, L. A., & Havnes, I. A. (2025) · Scandinavian Journal of Primary Health Care · doi:10.1080/02813432.2025.2517769 · Cited by 2
“…patients, including the recommendations for opioid use and tapering, a finding consistent with previous research [91]. to reduce the harms associated with opioid prescribing, guidelines on opioids for chronic pain have, in recent years, been updated in the Us, canada and the UK [55,63,92,93].”
Comparison of opioid use among long-term care residents in Ontario and Alberta, Canada: A multi-jurisdictional, repeated cross-sectional study
Maxwell, C. J., Campitelli, M. A., Gruneir, A., Iaboni, A., Maclagan, L. C., Hogan, D. B., Youngson, E. R. E., Chen, X., Li, Z., & Bronskill, S. E. (2025) · Canadian Journal of Pain · doi:10.1080/24740527.2025.2518151 · Cited by 2
“44 In AB, prescribers are advised (via the provincial Tracked Prescription Program [TPP] administered by the College of Physicians & Surgeons of Alberta [CPSA]) 30 to follow optimal prescribing practices, including use of the lowest effective dose and lower potency options.”
Factors associated with opioid craving, opioid intake, and opioid misuse in patients with chronic pain: insights from an ecological momentary assessment study
Bruneau, A., Sirois, A., Spiegler, G., Bi, J., Petkau, S., Djoudi, Y.-L., Ware, J., Alghamdi, R. I. A. D. N. A., Nipa, N., Perreault, M., et al. (2025) · Pain · doi:10.1097/j.pain.0000000000003753 · Cited by 2
Personalized pain management: The use of pharmacogenomics in pain treatment strategies
Scott, E. N., Simonson, L., & Loucks, C. M. (2026) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2025-0304 · Cited by 3
Medical management of chronic pain
Peng, P. (2018) · Canadian Urological Association Journal · doi:10.5489/cuaj.5323 · Cited by 2
Review of Opioid Prescribing in the Osteopathic and Ambulatory Setting
Hussein, A. I., Bekampis, C. F., & Jermyn, R. T. (2019) · Journal of Osteopathic Medicine · doi:10.7556/jaoa.2019.134 · Cited by 2
A Population Study of Prescribed Opioid-based Pain Reliever Use among Individuals with Mood and Anxiety Disorders in Canada
Liu, L. J. W., Bach, P., Crispo, J. A. G., Kramer, J. L. K., & Cragg, J. J. (2020) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2020.108229 · Cited by 2
“However, the guidelines have not focused on those with mental health disorders (Busse et al., 2017).”
Background
Acceptability of Physiotherapists in the Emergency Department for the Care of Adults With Musculoskeletal Disorders
Béland, A., Matifat, E., Cournoyer, É., Perreault, K., & Desmeules, F. (2021) · Journal of Acute Care Physical Therapy · doi:10.1097/jat.0000000000000178 · Cited by 2
Do expectations influence pain? Recognizing Irving Kirsch’s contribution to our understanding of pain
Locher, C., & Koechlin, H. (2022) · American Journal of Clinical Hypnosis · doi:10.1080/00029157.2022.2121677 · Cited by 2
“For context, chronic non-cancer pain is an umbrella term that includes painful conditions that persist or recur for more than 3 months and are not associated with a malignant disease (Busse et al., 2017; Merskey & Bogduk, 1994).”
Background
Recent trends in the prescription of opioids in the emergency department in patients with urolithiasis
Liem, S. S., Demus, T., Pérez, A., Jivanji, D. R., Lee, C. Y., George, K., Perez, A., Cubeddu, L. X., & Pereira, J. F. (2023) · International Urology and Nephrology · doi:10.1007/s11255-023-03545-w · Cited by 2
“Overprescribing has played a major role in adverse opioid-related events [4, 5].”
Background
Temporal trends and patterns in initial opioid prescriptions after hospital discharge following colectomy in England over 10 years
Baamer, R. M., Humes, D. J., Toh, L. S., Knaggs, R., & Lobo, D. N. (2023) · BJS Open · doi:10.1093/bjsopen/zrad136 · Cited by 2
“Canadian guidelines recommend that the prescribed OMEQ dose should be limited to 50 mg/day 39 , while US guidelines advise prescribers to avoid increasing the dose to ≥ 90 mg/day 33 .”
Background
Perceptions in orthopedic surgery on the use of cannabis in treating pain: a survey of patients with spine pain (POSIT Spine)
Gjorgjievski, M., Madden, K., Bullen, C., Koziarz, F., Koziarz, A., Cenic, A., Li, S., Bhandari, M., & Johal, H. S. (2024) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-024-04558-6 · Cited by 2
“Treatment guidelines for non-specific back pain recommend non-pharmacological care as first-line and discour-age the use of opioids [6, 7].”
BackgroundResult
Take-Home Naloxone Access and Use among Older Adults Living with Pain: A Scoping Review
Chan, R. R. D., Yakiwchuk, E., & Halpape, K. (2024) · The Canadian Journal of Hospital Pharmacy · doi:10.4212/cjhp.3506 · Cited by 2
New opioid prescription claims and their clinical indications: results from health administrative data in Quebec, Canada, over 14 years
Attisso, E. A., Guénette, L., Dionne, C. E., Kröger, E., Dialahy, I. Z., Tessier, S., & Jean, S. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-077664 · Cited by 2
The impact of chiropractic care on prescription opioid use for non-cancer spine pain: protocol for a systematic review and meta-analysis
Emary, P. C., Corcoran, K. L., Coleman, B. C., Brown, A. L., Ciraco, C., DiDonato, J., Wang, L., Couban, R., Sud, A., & Busse, J. W. (2024) · Systematic Reviews · doi:10.1186/s13643-024-02654-6 · Cited by 2
“…optimization of non-opioid pharmacotherapy and non-pharmacologic treatments (e.g. education, exercise, cognitive behavioural therapy, soft-tissue massage, spinal manipulation) rather than prescription opioids as first-line therapy for acute or chronic non-cancer musculoskeletal pain [6, 8, 9].”
BackgroundMethodSelf-citation
Views and perspectives toward implementing the Global Spine Care Initiative (GSCI) model of care, and related spine care program by the people in Cross Lake, Northern Manitoba, Canada: a qualitative study using the Theoretical Domain Framework (TDF)
Robak, N., Broeckelmann, E. M., Mior, S. A., Atkinson-Graham, M., Ward, J., Scott, M. E., Passmore, S. R., Kopansky-Giles, D. R., Tavares, P., Moss, J., et al. (2024) · Implementation Science Communications · doi:10.1186/s43058-024-00636-2 · Cited by 2
“The MoC incorporates best practices consistent with recent evidence-based clinical practice guideline recommendations [12, 14–17], while considering unique local cultural influences, health system and economic design, and needed resources to support delivery of care.”
MethodResult
Opioids and Cannabinoids in Neurology Practice
Sandbrink, F., & Schuster, N. M. (2024) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001487 · Cited by 2
Risk of infections among persons treated with opioids for chronic pain: a systematic review and meta-analysis protocol
Kudrina, I., Pagé, M. G., Choinière, M., Shir, Y., Eisenberg, M. J., Ben-Sasson, M., Lebouché, B., & Puzhko, S. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-083791 · Cited by 2
Expanding Opioid Stewardship: Collaboration between Hospital and Primary Care Pharmacists
Lac, J., Leung, C., Yan, K., Kapanen, A. I., & Tilli, T. (2025) · The Canadian Journal of Hospital Pharmacy · doi:10.4212/cjhp.3664 · Cited by 2
Evaluating regional and temporal variations in quality indicators for opioid initiation and pharmacist medication reviews in Ontario: A population-based repeated cross-sectional study
Torabi, A., Chu, C., Aziz, Y. H. A., Yada, N., Chaudhry, S., Wang, T., Gomes, T., & Tadrous, M. (2025) · Canadian Pharmacists Journal / Revue des Pharmaciens du Canada · doi:10.1177/17151635251358873 · Cited by 2
Healthcare practitioner use of real-time prescription monitoring tools: an online survey
Hoppe, D., Liu, C., & Khalil, H. (2023) · Australian Health Review · doi:10.1071/ah22257 · Cited by 2
Prevalence and Characterization of Breakthrough Pain Associated with Chronic Low Back Pain in the South of Spain: A Cross-Sectional, Multicenter, Observational Study
Torres, L. M., Jiménez, A. J., Cabezón, A. C. M., & Rodríguez, M. J. (2018) · Pain Research and Treatment · doi:10.1155/2018/4325271 · Cited by 2
“Pain Takes Over Everything”: The Experience of Pain and Strategies for Management
Crowe, M., Gillon, D., McCall, C., & Jordan, J. (2019) · Springer eBooks · doi:10.1007/978-3-030-24154-4_4 · Cited by 2
Effectiveness of Risk Minimization Measures for Fentanyl Buccal Tablet (FENTORA) in Canada: A Mixed-Methods Evaluation Using Surveys, Medical Chart Records and Web Surveillance
Kaplan, S., Bergamasco, A., Sergerie, M., Castilloux, A., & Moride, Y. (2019) · Drug Safety · doi:10.1007/s40264-019-00882-7 · Cited by 2
Identifying appropriate outcomes to help evaluate the impact of the Canadian Guideline for Safe and Effective Use of Opioids for Non-Cancer Pain
Allen, M., Sproule, B. A., MacDougall, P., Furlan, A. D., Murphy, L. L., Debono, V. B., & Buckley, N. (2020) · BMC Anesthesiology · doi:10.1186/s12871-020-0930-4 · Cited by 2
Pharmaceutical practices before and throughout the opioid crisis: A scoping review
Samaha, N.-T., Vanier, M., & David, P. (2020) · Journal of the American Pharmacists Association · doi:10.1016/j.japh.2020.03.026 · Cited by 2
Low-dose methadone for refractory chronic migraine accompanied by medication-overuse headache: a prospective cohort study
Benemei, S., Lupi, C., Cesaris, F. D., Lombardi, N., Bettiol, A., Chiarugi, A., Geppetti, P., Galli, V., Pracucci, C., Occupati, B., et al. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04602-3 · Cited by 2
Postpartum Analgesia in New Mothers (PAIN) Study: A Survey of Canadian Obstetricians’ Post-Delivery Opioid-Prescribing Practices
Harris, M. T. H., McDonald, E. G., Marrone, E., El‐Messidi, A., Girard, T., Gosselin, S., Gunn, C. M., Shapiro, G. D., Longo, C., & Dayan, N. (2020) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2020.11.018 · Cited by 2
Association between sustained opioid prescription and frequent emergency department use: a cohort study
Racine-Hemmings, F., Vanasse, A., Lacasse, A., Chiu, Y. M., Courteau, J., Dépelteau, A., & Hudon, C. (2022) · Emergency Medicine Journal · doi:10.1136/emermed-2021-211180 · Cited by 2
Comparison of Older and Younger Patients Referred to a Non-interventional Community Pain Clinic in the Greater Toronto Area (GTA)
Lakha, S. F., Assimakopoulos, D., & Mailis, A. (2022) · Pain and Therapy · doi:10.1007/s40122-022-00435-4 · Cited by 2
“The cut-off point of 90 mg/day between the two opioid user groups was defined by the 2017 Canadian guidelines for safe and effective use of opioids for chronic non-cancer pain [19].”
Chronic non-cancer pain management – insights from Australian general practitioners: a qualitative descriptive study
Gilkes, L., Bulsara, C., & Mavaddat, N. (2023) · Australian Journal of Primary Health · doi:10.1071/py22144 · Cited by 2
Safe Prescribing Practices: Clinicians' Views on Prescribing Opioids to Patients With Early-Stage Cancer
Wood, T., Cheung, W. Y., Ruether, D., Sinnarajah, A., Tanguay, R. L., Tarumi, Y., Lau, J., & Cuthbert, C. A. (2023) · JCO Oncology Practice · doi:10.1200/op.22.00766 · Cited by 2
“Chronic pain is pain that lasts 3months or longer,(22) and chronic opioid use is defined as the continuous use of opioids for 3 months or longer.(23) While terminologies related to problematic opioid use are evolving,(24) we consider the current definition of opioid misuse as the use of a medication for a medical purp…”
Background
Cross-sectional study of rapid tapering of opioid prescriptions following medical regulatory intervention in Alberta from 2013 to 2020
Hernández-Cerón, N., Gilani, F., Hurava, I., Kain, N. A., & Ashworth, N. L. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-070066 · Cited by 2
OralOpioids: Harnessing R Programming and Data Science to Combat Opioid Misuse
Banerjee, A., & Stricker, E. (2023) · Health Services Research and Managerial Epidemiology · doi:10.1177/23333928231208251 · Cited by 2
Opioid dose risk, clinician and patient characteristics, and adherence to opioid prescribing recommendations in chronic non-cancer pain
Coleman, C., Lennon, R. P., Robinson, J. M., Tuan, W., Sehgal, N., & Zgierska, A. E. (2023) · Journal of Opioid Management · doi:10.5055/jom.0815 · Cited by 2
Determinants of successful opioid deprescribing: Insights from French pain physicians—A qualitative study
Nizet, P., Deme, L., Evin, A., Kuhn, E., Nizard, J., Victorri‐Vigneau, C., & Huon, J. (2024) · Pain Practice · doi:10.1111/papr.13409 · Cited by 2
Opioid use disorders as an emerging disability
Lusk, S. L., & Stipp, A. (2018) · Journal of Vocational Rehabilitation · doi:10.3233/jvr-180943 · Cited by 2
“Busse et al. (2017) recommends the use of “nonopioid pharmacotherapy and nonpharmacological therapy” for individuals with chronic, noncancer pain (p. E659).”
Laxative Use in Inpatients on Oxycodone/Naloxone Prolonged Release and Oxycodone Prolonged Release for Cancer and Non-cancer Pain
Patel, J., Lucas, C. J., Margalit, M., & Martin, J. H. (2018) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.1080/15360288.2018.1545725 · Cited by 2
Prescription of High-Dose Opioids Among People Living with HIV in British Columbia, Canada
the STOP HIV/AIDS in BC Study Group, Clark, J., Fairbairn, N. S., Nolan, S., Li, T., Wu, A., Barrios, R., Montaner, J. S. G., & Ti, L. (2019) · AIDS and Behavior · doi:10.1007/s10461-019-02589-3 · Cited by 2
“Nevertheless, guidelines caution against prescribing > 90 MME/day so our findings were relevant regardless [14, 25].”
BackgroundInfluential
Sensible approaches to manage the current opioid crisis
Desapriya, E., & Ratnaweera, K. (2017) · Canadian Medical Association Journal · doi:10.1503/cmaj.733161 · Cited by 2
Role of regulators in safe prescribing of opioids
Oetter, H. M. (2017) · Canadian Medical Association Journal · doi:10.1503/cmaj.733125 · Cited by 2
Inconsistencies in the 2017 Canadian Guideline for Opioids for Chronic Noncancer Pain
Weinberg, E. L., & Baer, P. A. (2017) · Canadian Medical Association Journal · doi:10.1503/cmaj.733244 · Cited by 2
Opioids for chronic pain
Ross, M. (2018) · Canadian Medical Association Journal · doi:10.1503/cmaj.68954 · Cited by 2
Prescribing Opioids for Severe Hip and Knee Osteoarthritis Varies Widely in the United States: The Devil Is in the Details
Pope, J. E. (2019) · Arthritis & Rheumatology · doi:10.1002/art.40833 · Cited by 2
Opioids
Furlan, A. D., & Murphy, L. L. (2022) · Wiley eBooks · doi:10.1002/9781119701170.ch18 · Cited by 2
Comparison of Different Modeling Approaches for Prescription Opioid Use and Its Association With Adverse Events
Kurteva, S., Abrahamowicz, M., Beauchamp, M., & Tamblyn, R. M. (2023) · American Journal of Epidemiology · doi:10.1093/aje/kwad115 · Cited by 1
“Time-varying indicators of physical and mental health comorbidities that are likely associated with increased pain, and thus may lead to increased opioid use, were also constructed (18, 38).”

Authors: Busse, J. W., Craigie, S., Juurlink, D. N., Buckley, D. N., Wang, L., Couban, R. J., Agoritsas, T., Akl, E. A., Carrasco-Labra, A., Cooper, L., Cull, C., da Costa, B. R., Frank, J. W., Grant, G., Iorio, A., Persaud, N., Stern, S., Tugwell, P., Vandvik, P. O., & Guyatt, G. H.
Affiliations: University of Bern (CH)
ORCID: Busse, Jason W.
Juurlink, David N.
Buckley, D. Norman
Wang, Li
Couban, Rachel J.
Agoritsas, Thomas
Akl, Elie A.
Cooper, Lynn
Cull, Chris
Frank, Joseph W.
Iorio, Alfonso
Persaud, Navindra
Tugwell, Peter
Vandvik, Per Olav
Guyatt, Gordon H.
Venue: Canadian Medical Association Journal
Publisher: CMA Impact Inc.
Published: 2017-05-07
Volume: 189
Issue: 18
Pages: E659-E666
ISSN: 0820-3946 (ISSN-L)
1488-2329
DOI: 10.1503/cmaj.170363
PMC: PMC5422149
OpenAlex: W2612284626
Cited by: 707
References: 50
Citations by year: 2026: 37 · 2025: 58 · 2024: 71 · 2023: 59 · 2022: 82 · 2021: 107 · 2020: 105 · 2019: 86 · 2018: 67 · 2017: 29
FWCI: 73.70
Type: journal article
Language: en
Open access: gold
doi.org
Locations: Canadian Medical Association Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
BORIS (University Library Bern) (submittedVersion)
Funders: U.S. Department of Veterans Affairs (IK2 HX001914)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
Keywords: opioid therapy, chronic non-cancer pain, pain management, opioid prescribing
MeSH terms: Analgesics, Opioid, Dose-Response Relationship, Drug, Humans, Opioid-Related Disorders, Pain Measurement, Primary Health Care, Treatment Outcome, Drug Monitoring, Chronic Pain

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Guideline for opioid therapy and chronic noncancer pain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks