The Relationship Between Serum Levels of Interleukin-6 and Thyroid Hormone During the Follow-up Study in Children with Nonthyroidal Illness: Marked Inverse Correlation in Kawasaki and Infectious Disease.
Open accessAbstract
Our previous study demonstrated that the serum IL-6 correlated inversely with serum T3 and the T3/T4 ratio in children with acute respiratory infection during the acute phase of illness. To investigate whether serum IL-6 inversely correlates with serum thyroid hormone during not only the active stage of the disease but also in the follow-up period in nonthyroidal illness, we measured serum levels of IL-6, T3 and T4 in 31 children from the acute to the convalescent phase. They were divided into 3 groups; 7 patients with Kawasaki disease, 16 patients with infectious disease and 8 patients with non-inflammatory disease. In the follow-up of patients with Kawasaki disease, a marked inverse relationship was observed between serum IL-6 and T3 (r = -0.844, P < 0.001) or the T3/T4 ratio (r = -0.863, P < 0.001). Serum T4 showed a weak but significant negative correlation with serum IL-6 (r = -0.474, P = 0.035) only in this situation. There was also a significant negative correlation between serum IL-6 and T3 (r = -0.582, P < 0.001) or the T3/T4 ratio (r = -0.660, P < 0.001) during the follow-up of children with infectious disease. In the follow-up study of patients with non-inflammatory disease, however, no significant relationships were observed between serum thyroid hormones and IL-6. IL-6 may be one important factor involved in the decrease in the serum T3 level and the T3/T4 ratio in patients with nonthyroidal illness particularly characterized by strong inflammation and activation of the immune system as observed in Kawasaki and infectious disease.
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It seems likely that levels of thyroid hormones are low in chronic rheumatic diseases as demonstrated in systemic lupus erythematosus and Kawasaki disease.
“Although not many studies in chronic rheumatic diseases exist, it seems likely that levels of thyroid hormones are low as demonstrated in SLE and Kawasaki disease [133,134].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [134]
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Interaction of the endocrine system with inflammation: a function of energy and volume regulation
Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4484 · Cited by 121 · see citing works
“Although not many studies in chronic rheumatic diseases exist, it seems likely that levels of thyroid hormones are low as demonstrated in SLE and Kawasaki disease [133,134].”
Background
- Authors
- HASHIMOTO, H., IGARASHI, N., YACHIE, A., MIYAWAKI, T., HASHIMOTO, T., & SATO, T.
- Affiliations
- Kanazawa University (JP)
- Venue
- Endocrine Journal
- Publisher
- Japan Endocrine Society
- Published
- 1996
- Volume
- 43
- Issue
- 1
- Pages
- 31-38
- ISSN
- 0918-8959 (ISSN-L)
- 1348-4540
- OpenAlex
- W2064261067
- Cited by
- 21
- References
- 34
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2015: 3 · 2014: 1 · 2012: 1
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrine Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Kawasaki Disease and Coronary Complications
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- interleukin-6, thyroid hormones, triiodothyronine, T3/T4 ratio, low T3 syndrome, Kawasaki disease, infectious diseases, children, inflammation, convalescence, immune activation
- MeSH terms
- Adolescent, Child, Child, Preschool, Humans, Infant, Infections, Mucocutaneous Lymph Node Syndrome, Respiratory Tract Infections, Thyroxine, Triiodothyronine, Interleukin-6
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