Association between serum interleukin-6 and serum 3,5,3'-triiodothyronine in nonthyroidal illness.
Abstract
Increased serum concentrations of FFA, bilirubin, and carboxyl-methyl-propyl-furanpropionic acid, accumulating in chronic renal failure in direct relationship with serum creatinine, have all been implicated in the pathogenesis of the low T3 syndrome during illness. Cytokines may also be involved in the sick euthyroid syndrome. In contrast to interleukin-1 (IL-1) and tumor necrosis factor-alpha, IL-6 is usually detectable in serum during illness and acts as a systemic hormone. We studied the association between serum T3 and IL-6 in consecutive hospital admissions with a wide variety of medical conditions. Patients were divided into group A (T3, > or = 1.30 nmol/L; T4, > or = 75 nmol/L; n = 41), group B (T3, or = 75 nmol/L; n = 46), and group C (T3, < 1.30 nmol/L; T4, < 75 nmol/L; n = 13). Serum IL-6 levels in groups C and B were higher than those in group A (median values 59, 39, and 9 U/mL, respectively; P < 0.01). Serum creatinine and bilirubin/albumin ratios were similar in the three groups, but the FFA/albumin ratio in group C was higher than in group A (P < 0.05). When all patients were analyzed together, serum T3 was negatively correlated to serum IL-6 (r = -0.56; P < 0.001), bilirubin/albumin ratio (r = -0.29; P = 0.004), and FFA/albumin ratio (r = -0.21; P = 0.03), but not with creatinine (r = -0.16; P = 0.11). Stepwise multiple regression resulted in the following equation: serum T3 = 2.13-0.18ln(IL-6)-0.15ln(creatinine)-0.094ln(bilirubin /albumin) (r = 0.61). The var…
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Interleukin 6 (IL-6) is negatively correlated with serum T3 concentrations in hospitalized patients.
“An early clinical observation was that interleukin 6 (IL-6), a systemic, proinflammatory cytokine, is negatively correlated with serum T3 concentrations in hospitalized patients [49].”
From An update on non-thyroidal illness syndrome (2021) · cites this paper as [49]
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- Authors
- Boelen, A., Platvoet-Ter Schiphorst, M. C., & Wiersinga, W. M.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- ORCID
- Boelen, A
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1993-12
- Volume
- 77
- Issue
- 6
- Pages
- 1695-1699
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2000252862
- Cited by
- 196
- References
- 0
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 12 · 2015: 7 · 2014: 7 · 2013: 5 · 2012: 5
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- interleukin-6, triiodothyronine, low T3 syndrome, cytokines, free fatty acids, bilirubin/albumin ratio, serum creatinine, thyroid hormone levels, chronic kidney disease, hospitalized patients, T3/T4 ratio
- MeSH terms
- Adult, Aged, C-Reactive Protein, Fatty Acids, Nonesterified, Humans, Middle Aged, Regression Analysis, Serum Albumin, Triiodothyronine, Interleukin-6
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