Global fibrinolytic capacity in patients with subclinical hypothyroidism
Open accessAbstract
Subclinical hypothyroidism (SH) represents the earliest stages of hypothyroidism but the benefits of detecting and treating SH are not well known. The aim of this study was to evaluate the alterations in global fibrinolytic capacity (GFC), which indicates the overall fibrinolytic activity, in patients with SH. The study group comprised of 15 patients with SH and 15 healthy controls. The GFC was significantly lower in patients with SH than in control group (p<0.002). This result suggests a relative hypercoagulable state in SH.
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Subclinical hypothyroidism patients have lower global fibrinolytic activity, such as tissue plasminogen activator, than euthyroid controls.
“This is further supported by a study that found lower global fibrinolytic activity, such as tissue plasminogen activator, in SCH patients than in euthyroid controls (68).”
From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [68]
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- Authors
- GULDIKEN, S., DEMIR, M., TURGUT, B., ALTUN, B. U., ARIKAN, E., & KARA, M.
- Affiliations
- Department of Endocrinology and Metabolism, Faculty of Medicine, Trakya University
- Trakya University (TR)
- ORCID
- TURGUT, Burhan
- Venue
- Endocrine Journal
- Publisher
- Japan Endocrine Society
- Published
- 2005
- Volume
- 52
- Issue
- 3
- Pages
- 363-367
- ISSN
- 0918-8959 (ISSN-L)
- 1348-4540
- OpenAlex
- W2023112696
- Cited by
- 37
- References
- 22
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 3 · 2013: 1 · 2012: 1
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrine Journal (publishedVersion)
- PubMed (publishedVersion)
- Trakya University's Institutional Open Access System (Trakya University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- subclinical hypothyroidism, fibrinolysis, hypercoagulability, coagulation, hypothyroidism
- MeSH terms
- Adult, Female, Fibrin, Fibrin Fibrinogen Degradation Products, Fibrinolysis, Humans, Hypothyroidism, Tissue Plasminogen Activator, Thyrotropin, Thyroxine, Triiodothyronine, Statistics, Nonparametric
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