Primary haemostasis in thyroid disease
Abstract
Abstract. Objectives. There have been reports on a bleeding tendency in hypothyroidism resembling von Willebrand's disease. The aim of the present study was to investigate whether altered primary haemostasis is a general phenomenon in thyroid disease. Design/setting. A total of 10 patients with hyperthyroidism and nine patients with hypothyroidism were studied at diagnosis, and during treatment with carbimazole or L‐thyroxine. respectively, when euthyroidism had been achieved. Results. In untreated hypothyroidism, template bleeding time was prolonged (median 9.3 min, range 3.8–20.0 min) compared to that in controls (median 4.0 min, range 3.0–6.0 min; P < 0.05). whereas maximal agglutination velocity induced by ristocetin was decreased (38% min−1, range 4–52% min−1 vs. 70% min−1, range 60–81% min−1, P < 0.05). The level of von Willebrand factor antigen in plasma from hypothyroid patients was less than half of the value in hyperthyroid patients. This difference disappeared after euthyroidism was achieved. Conclusions. We found that changed primary haemostasis is a general feature of hypothyroidism, and that it is resolved after levothyroxine treatment.
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Excess thyroid hormone activity results in a procoagulant state, with increased VWF, FVIII, fibrinogen, and D-dimer in subclinical hyperthyroidism and elevations in fibrinogen, fibronectin, VWF, thrombomodulin, and PAI-1, with decreased t-PA in overt endogenous hyperthyroidism.
“Excess thyroid hormone activity results in a procoagulant state, with increased VWF, FVIII, fibrinogen, and D-dimer in subclinical hyperthyroidism and elevations in fibrinogen, fibronectin, VWF, thrombomodulin, and PAI-1, with decreased t-PA in overt, endogenous hyperthyroidism”
From Pharmacodynamic and Therapeutic Actions of Levothyroxine (2021) · cites this paper as [115]
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- Authors
- MYRUP, B., BREGENGÅRD, C., & FABER, J.
- Affiliations
- Frederiksberg Hospital (DK)
- Corresponding author
- MYRUP, B.
- ORCID
- FABER, J.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 1995-07
- Volume
- 238
- Issue
- 1
- Pages
- 59-63
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2164313235
- Cited by
- 72
- References
- 20
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 2 · 2014: 1 · 2013: 4 · 2012: 2
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Keywords
- primary hemostasis, thyroid dysfunction, hypothyroidism, hyperthyroidism, bleeding tendency, von Willebrand factor, bleeding time, ristocetin-induced platelet aggregation, levothyroxine, carbimazole, euthyroidism
- MeSH terms
- Adult, Aged, alpha-Macroglobulins, Bleeding Time, Blood Coagulation Factors, Carbimazole, Female, Fibrinogen, Fibronectins, Hemostasis, Humans, Hyperthyroidism, Hypothyroidism, Male, Middle Aged, Platelet Aggregation, Thyroxine, von Willebrand Factor
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