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Cited by 16Ion Transport and Channel RegulationElectrolyte and hormonal disordersEstrogen and related hormone effects

Effect of Ovarian Steroids on Cyclic Adenosine 3':5'-Monophosphate Production Stimulated by Arginine Vasopressin in Rat Renal Monolayer Cultured Cells.

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HATANO, TAKASHI, OGAWA, KATSUHITO, KANDA, KAZUMI, SEO, HISAO, MATSUI, NOBUO·1988·Endocrinologia Japonica
DOI 10.1507/endocrj1954.35.267
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Abstract

Renal resistance to antidiuretic hormone (ADH) has been speculated to be a mechanism of transient nephrogenic diabetes insipidus occurring during late pregnancy. In order to study possible involvement of ovarian steroids in this mechanism, their effect on cyclic adenosine 3':5'-monophosphate (cAMP) response to arginine vasopressin (AVP) was examined utilizing rat and human renal medullary cells in monolayer culture. In both rat and human cells, estradiol significantly reduced cAMP response to AVP; estradiol at 1.84 x 10(-8) M, 1.84 x 10(-7) M and 1.84 x 10(-6) M decreased cAMP production stimulated by 10(-8) M AVP to 78 +/- 5%, 67 +/- 2% (P less than 0.05) and 52 +/- 1% (P less than 0.001) of the control in rat renal cells, respectively, and in human renal cells the effect of estradiol was comparable to that in rat cells. In rat renal cells, progesterone also reduced cAMP response to AVP dose-dependently; progesterone at 1.59 x 10(-7) M, 1.59 x 10(-6) M and 1.59 x 10(-5) M decreased cAMP production stimulated by 10(-8) M AVP to 87 +/- 1%, 72 +/- 5% (P less than 0.001) and 37 +/- 5% (P less than 0.001) of the control, respectively. On the other hand, corticosterone and dexamethasone at concentrations ranging from 10(-8) M to 10(-5) M and aldosterone at concentrations ranging from 10(-9) M to 10(-5) M did not alter cAMP response to AVP significantly. The suppressive effect of estradiol increased with time until six hours and thereafter it reached a plateau.(ABSTRACT TRUNCATED AT 250 WORDS)

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  • The absence of an effect on renal free water clearance suggests that estrogens may reduce renal sensitivity to AVP or interfere with AVP action in the kidney.

    “This lack of effect on renal free water clearance suggested to us that estrogens may alter renal sensitivity to AVP or even interfere with AVP action in the kidney (9) as has been noted in collecting ducts of rat kidneys (9).”

    From Sex Hormone Effects on Body Fluid Regulation (2008) · cites this paper as [9]

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Authors
HATANO, T., OGAWA, K., KANDA, K., SEO, H., & MATSUI, N.
Affiliations
  • Research Institute of Environmental Medicine, Nagoya University (JP)
  • Department of Internal Medicicine, Toyohashi National Hospital
Venue
Endocrinologia Japonica
Publisher
Japan Endocrine Society
Published
1988
Volume
35
Issue
2
Pages
267-274
ISSN
  • 0013-7219 (ISSN-L)
  • 2185-6370
DOI
10.1507/endocrj1954.35.267
OpenAlex
W2084888550
Cited by
16
References
18
Citations by year
2026: 2 · 2021: 1 · 2014: 1
FWCI
0.26
Type
journal article
Language
en
Open access
Locations
  • Endocrinologia Japonica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
ovarian steroids, cyclic AMP, vasopressin, renal medullary cells, estradiol, progesterone, nephrogenic diabetes insipidus, pregnancy, aldosterone, corticosteroids, dexamethasone
MeSH terms
Cyclic AMP, Animals, Arginine Vasopressin, Cells, Cultured, Estradiol, Humans, Kidney, Male, Progesterone, Rats, Inbred Strains, Rats

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