CoChat
Sign Up
Cited by 106Chronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseasesCystic Fibrosis Research Advances

Interventions to reduce rehospitalizations after chronic obstructive pulmonary disease exacerbations: a systematic review

Open access
Prieto-Centurion, Valentin, Markos, Michael A., Ramey, Norma I., Gussin, Hélène A., Nyenhuis, Sharmilee M., Joo, Min J., Prasad, Bharati, Bracken, Nina +11 more·2014·Annals of the American Thoracic Society
DOI 10.1513/annalsats.201308-254ocPMC PMC5467116
Open this paper in CoChat — free account

Abstract

RATIONALE: Approximately 20% of patients hospitalized for COPD exacerbations in the United States will be readmitted within 30 days. The Centers for Medicare and Medicaid Services has recently proposed to revise the Hospital Readmissions Reduction Program to financially penalize hospitals with high all-cause 30-day rehospitalization rates after a hospitalization for COPD exacerbation on or after October 1, 2014. OBJECTIVES: To report the results of a systematic review of randomized clinical trials evaluating interventions to reduce the rehospitalizations after COPD exacerbations. METHODS: Multiple electronic databases were systematically searched to identify relevant studies published between January 1966 and June 2013. Titles, abstracts, and, subsequently, full-text articles were assessed for eligibility. Each study was appraised using predefined criteria. MEASUREMENTS AND MAIN RESULTS: Among 913 titles and abstracts screened, 5 studies (1,393 participants) met eligibility criteria. All studies had a primary outcome of rehospitalization at 6 or 12 months. No study examined 30-day rehospitalization as the primary outcome. Each study tested a different set of interventions. Two studies (one conducted in Canada and one conducted in Spain and Belgium) showed a decrease in all-cause rehospitalization over 12 months in the intervention group versus comparator group (mean number of hospitalizations per patient, 1.0 vs. 1.8; P = 0.01; percent hospitalized, 45 vs. 67%; P = 0.028; respectively). The only study conducted in the United States found a greater than twofold higher risk of mortality in the intervention group (17 vs. 7%, P = 0.003) but no significant difference in rehospitalizations. It was unclear which set of interventions was effective or harmful. CONCLUSIONS: The evidence base is inadequate to recommend specific interventions to reduce rehospitalizations in this population and does not justify penalizing hospitals for high 30-day rehospitalization rates after COPD exacerbations.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1513/annalsats.201308-254oc

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. [4]US CongressHouse Committee on Ways and Means, Committee on Energy and Commerce, Committee on Education and Labor. Compilation of Patient Protection and Affordable Care Act: As amended through 1 November 2010, including Patient Protection and Affordable Care Act health-related portions of the Health Care and Education Reconciliation Act of 2010. Washington, DC: U.S. Government Printing Office; 2010. xxiii [Google Scholar]
  2. [23]Prieto-Centurion V, DiDomenico R, Godwin P, Grude-Bracken N, Gussin H, Jaffe HA, Joo MJ, Markos MA, Nyenhuis S, Pickard AS, et al. A systematic review of interventions to reduce readmissions following COPD exacerbations [abstract] Am J Respir Crit Care Med. 2013;187:A2340. [Google Scholar]

Cited by

Sorted by citations

Related

Authors
Prieto-Centurion, V., Markos, M. A., Ramey, N. I., Gussin, H. A., Nyenhuis, S. M., Joo, M. J., Prasad, B., Bracken, N., DiDomenico, R., Godwin, P. O., Jaffe, H. A., Kalhan, R., Pickard, A. S., Pittendrigh, B. R., Schatz, B., Sullivan, J. L., Thomashow, B. M., Williams, M. V., & Krishnan, J. A.
Affiliations
  • University of Illinois Chicago (US)
  • Mercy Hospital and Medical Center (US)
  • University of Illinois Hospital & Health Sciences System (US)
  • Jesse Brown VA Medical Center (US)
  • Northwestern University (US)
  • University of Illinois Urbana-Champaign (US)
  • COPD Foundation (US)
  • Columbia University Irving Medical Center (US)
  • University of Kentucky (US)
Corresponding author
Krishnan, Jerry A.
ORCID
Venue
Annals of the American Thoracic Society
Publisher
Oxford University Press (OUP)
Published
2014-03-01
Volume
11
Issue
3
Pages
417-424
ISSN
  • 2325-6621 (ISSN-L)
  • 2329-6933
DOI
10.1513/annalsats.201308-254oc
PMC
PMC5467116
OpenAlex
W2022113560
Cited by
106
References
37
Citations by year
2026: 3 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 8 · 2021: 5 · 2020: 9 · 2019: 14 · 2018: 13 · 2017: 12 · 2016: 11 · 2015: 13 · 2014: 10
FWCI
2.62
Type
journal article
Language
en
Open access
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • Annals of the American Thoracic Society (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (T32HL082547, T32 2T32HL082547)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
Keywords
chronic obstructive pulmonary disease, COPD exacerbations, hospital readmission, rehospitalization prevention, Hospital Readmissions Reduction Program, 30-day readmission, post-discharge interventions, mortality
MeSH terms
Aged, Clinical Trials as Topic, Female, Hospitalization, Humans, Male, Pulmonary Disease, Chronic Obstructive

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review