The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.
The Origins of Asthma and Chronic Obstructive Pulmonary Disease in Early Life
Open accessAbstract
Results from birth cohort and cross-sectional studies of young children with wheezing have uncovered strong associations between both lung function and immune responses in early life and the subsequent development of persistent wheezing and chronic airway obstruction up to mid-adulthood. It is now apparent that the pattern of bronchial hyperresponsiveness, deficits in lung function, and structural airway remodeling that are characteristic of asthma may be already established during the preschool years in most patients. Interactions between acute viral infections, especially those due to rhinovirus and respiratory syncytial virus, and exposure to perennial aeroallergens may induce persistent alterations in immune responses and airway function in susceptible subjects. Similarly, deficits in airway function present shortly after birth predict airflow limitation in early adult life, which in turn is a strong predisposing factor for chronic obstructive pulmonary disease. The fact that these alterations are more likely to occur during early life and even in utero than later during childhood suggests that there a developmental window of susceptibility during which exposures can disrupt normal growth trajectories. Novel strategies for primary prevention of chronic respiratory diseases will be based on the identification of the genetic and environmental factors that interactively cause these disruptions.
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“Because lung development in utero and in childhood contributes to life-long trajectories of lung function,”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [316]
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“the effects of prenatal exposure to nicotine could have negative effects on respiratory health in middle-aged and older adults, including increased risk of asthma and chronic obstructive pulmonary disease (COPD).(315-317)”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [316]
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Cites
Chronic Obstructive Pulmonary Disease
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“Similarly to what was found in the Melbourne cohort, the lung function deficits of these two groups of children, relative to those with milder wheezing or without wheezing, remained unchanged between 9 and 26 years (20).”
BackgroundResultWheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children
Jackson, D. J., Gangnon, R. E., Evans, M. D., Roberg, K. A., Anderson, E. L., Pappas, T., Printz, M. C., Lee, W.-M., Shult, P. A., Reisdorf, E. S., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200802-309oc · Cited by 1,310
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Role of deficient type III interferon-λ production in asthma exacerbations
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Air pollution and its effects on the immune system
Glencross, D. A., Ho, T.-R., Camiña, N., Hawrylowicz, C. M., & Pfeffer, P. E. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.01.179 · Cited by 726
Farm living: effects on childhood asthma and allergy
von Mutius, E., & Vercelli, D. (2010) · Nature reviews. Immunology · doi:10.1038/nri2871 · Cited by 697
Airway remodeling in asthma: what really matters
Fehrenbach, H., Wagner, C., & Wegmann, M. (2017) · Cell and Tissue Research · doi:10.1007/s00441-016-2566-8 · Cited by 423
Al‐Muhsen, S., Johnson, J. R., & Hamid, Q. A. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.04.047 · Cited by 420
Air pollutants and early origins of respiratory diseases
Kim, D., Chen, Z., Zhou, L., & Huang, S. (2018) · Chronic Diseases and Translational Medicine · doi:10.1016/j.cdtm.2018.03.003 · Cited by 319
Metadata
- Authors
- Martinez, F. D.
- Affiliations
- University of Arizona (US)
- Corresponding author
- Martinez, Fernando D.
- Venue
- Proceedings of the American Thoracic Society
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-05-01
- Volume
- 6
- Issue
- 3
- Pages
- 272-277
- ISSN
- 1546-3222 (ISSN-L)
- 1943-5665
- PMC
- PMC2677402
- OpenAlex
- W2122312585
- Cited by
- 242
- References
- 53
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 11 · 2023: 6 · 2022: 12 · 2021: 19 · 2020: 13 · 2019: 10 · 2018: 15 · 2017: 14 · 2016: 19 · 2015: 16 · 2014: 12 · 2013: 19 · 2012: 21
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the American Thoracic Society (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (U10HL064307, HL-056177, HL064307, R01HL080083, R01HL056177, HL080083)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- asthma, chronic obstructive pulmonary disease, persistent wheezing, early life exposure, airway hyperresponsiveness, lung function, airway remodeling, respiratory viral infections, rhinovirus, respiratory syncytial virus, aeroallergens, immune response, primary prevention, preschool children
- MeSH terms
- Adult, Asthma, Child, Cross-Sectional Studies, Humans, Lung Diseases, Obstructive, Cohort Studies
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