Cited by 242Asthma and respiratory diseasesChronic Obstructive Pulmonary Disease (COPD) ResearchOccupational exposure and asthma

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The Origins of Asthma and Chronic Obstructive Pulmonary Disease in Early Life

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Martinez, Fernando D.·2009·Proceedings of the American Thoracic Society

DOI 10.1513/pats.200808-092rmPMC PMC2677402

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Abstract

Results from birth cohort and cross-sectional studies of young children with wheezing have uncovered strong associations between both lung function and immune responses in early life and the subsequent development of persistent wheezing and chronic airway obstruction up to mid-adulthood. It is now apparent that the pattern of bronchial hyperresponsiveness, deficits in lung function, and structural airway remodeling that are characteristic of asthma may be already established during the preschool years in most patients. Interactions between acute viral infections, especially those due to rhinovirus and respiratory syncytial virus, and exposure to perennial aeroallergens may induce persistent alterations in immune responses and airway function in susceptible subjects. Similarly, deficits in airway function present shortly after birth predict airflow limitation in early adult life, which in turn is a strong predisposing factor for chronic obstructive pulmonary disease. The fact that these alterations are more likely to occur during early life and even in utero than later during childhood suggests that there a developmental window of susceptibility during which exposures can disrupt normal growth trajectories. Novel strategies for primary prevention of chronic respiratory diseases will be based on the identification of the genetic and environmental factors that interactively cause these disruptions.

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Authors: Martinez, F. D.
Affiliations: University of Arizona (US)
Corresponding author: Martinez, Fernando D.
Venue: Proceedings of the American Thoracic Society
Publisher: Oxford University Press (OUP)
Published: 2009-05-01
Volume: 6
Issue: 3
Pages: 272-277
ISSN: 1546-3222 (ISSN-L)
1943-5665
DOI: 10.1513/pats.200808-092rm
PMC: PMC2677402
OpenAlex: W2122312585
Cited by: 242
References: 53
Citations by year: 2026: 4 · 2025: 5 · 2024: 11 · 2023: 6 · 2022: 12 · 2021: 19 · 2020: 13 · 2019: 10 · 2018: 15 · 2017: 14 · 2016: 19 · 2015: 16 · 2014: 12 · 2013: 19 · 2012: 21
FWCI: 2.45
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Proceedings of the American Thoracic Society (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (U10HL064307, HL-056177, HL064307, R01HL080083, R01HL056177, HL080083)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Keywords: asthma, chronic obstructive pulmonary disease, persistent wheezing, early life exposure, airway hyperresponsiveness, lung function, airway remodeling, respiratory viral infections, rhinovirus, respiratory syncytial virus, aeroallergens, immune response, primary prevention, preschool children
MeSH terms: Adult, Asthma, Child, Cross-Sectional Studies, Humans, Lung Diseases, Obstructive, Cohort Studies

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