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Epithelial-mesenchymal transition and its implications for fibrosis

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Kalluri, Raghu, Neilson, Eric G.·2003·Journal of Clinical Investigation
DOI 10.1172/jci200320530
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Abstract

Epithelial to mesenchymal transition (EMT) is a central mechanism for diversifying the cells found in complex tissues. This dynamic process helps organize the formation of the body plan, and while EMT is well studied in the context of embryonic development, it also plays a role in the genesis of fibroblasts during organ fibrosis in adult tissues. Emerging evidence from studies of renal fibrosis suggests that more than a third of all disease-related fibroblasts originate from tubular epithelia at the site of injury. This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors.

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Metadata

Authors
Kalluri, R., & Neilson, E. G.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2003-12-15
Volume
112
Issue
12
Pages
1776-1784
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci200320530
OpenAlex
W2032942532
Cited by
2,649
References
6
FWCI
20.05
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Epithelial-mesenchymal transition and its implications for fibrosis. https://app.cochat.ai/papers/10.1172/jci200320530
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Kalluri, R., & Neilson, E. G. (2003). Epithelial-mesenchymal transition and its implications for fibrosis. Journal of Clinical Investigation. https://doi.org/10.1172/jci200320530

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