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Borderlands/La Frontera: The New Mestiza
Abstract
The chemokine receptor CCR9 and its only known ligand CCL25 play an important role in gut inflammation and autoimmune colitis. The function of CCR9-CCL25 in the migration of immune cells is well characterized. However, its role in the immune cell differentiation is mostly not known. Using dextran sodium sulfate (DSS)-induced gut inflammation model, we showed that CCR9+ dendritic cells (DCs) specifically CD11b- CD103+ DCs were significantly increased in the gut-associated lymphoid tissues (GALT) compared to control mice. These CCR9+ DCs express lower MHC II and CD86 molecules and had regulatory surface markers (FasL and latency-associated peptide, LAP) in the GALT. In the presence of CCL25, CCR9+ DCs promoted in vitro differentiation of Foxp3+ regulatory CD4+ T cells (Tregs). CCL25-induced differentiation of Tregs was due to intrinsic signaling in the DCs but not through CD4+ T cells, which was driven by the production of thymic stromal lymphopoietin (TSLP) and not IL-10. Furthermore, adoptive transfer of CCR9+ DCs in C57BL/6 mice promoted Tregs but reduced the Th17 cells in the GALT, and also suppressed the OVA-specific gut-allergic response. Our results suggest CCR9+ DCs have a regulatory function and may provide a new cellular therapeutic strategy to control gut inflammation and allergic immune reaction.
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Metadata
- Authors
- Anzaldúa, G.
- Corresponding author
- Anzaldúa, Gloria
- Venue
- Censored
- Publisher
- McGill-Queen's University Press
- Published
- 2017-09-05
- Pages
- 381-399
- OpenAlex
- W184192484
- Cited by
- 10,736
- References
- 0
- Citations by year
- 2026: 21 · 2025: 581 · 2024: 722 · 2023: 724 · 2022: 727 · 2021: 755 · 2020: 714 · 2019: 645 · 2018: 587 · 2017: 449
- FWCI
- 5434.34
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- McGill-Queen's University Press eBooks (publishedVersion)
- Topics
- Social Sciences › Cultural Studies › Latin American and Latino Studies
- Social Sciences › Arts and Humanities › Literature and Literary Theory › Latin American Literature Analysis
- Social Sciences › Arts and Humanities › History › Latin American history and culture
- Keywords
- borderlands, mestizaje, mestiza, race and ethnicity, identity
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