The DOI matches its Crossref record; 89 of the 90 references it cites were found in a registry or an index.
Alzheimer’s disease as an inflammatory disease
Open accessAbstract
Alzheimer's disease (AD) is a neurodegenerative condition characterized by the formation of amyloid-β plaques, aggregated and hyperphosphorylated tau protein, activated microglia and neuronal cell death, ultimately leading to progressive dementia. In this short review, we focus on neuroinflammation in AD. Specifically, we describe the participation of microglia, as well as other factors that may contribute to inflammation, in neurodegeneration.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Persistent activation of microglia and astrocytes elevates inflammatory mediators like chemokines and cytokines [79], the ROS and RNS release, with neurotoxic effects and responsible for chronic neurological/neurodegenerative disorders [80,81,82].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [79]
In the citing paper
“In AD, the increase in soluble Aβ oligomeric species, aggregated Aβ plaques and neurofibrillary tangles of hyperphosphorylated Tau proteins leads to activation of microglia and thus to neuroinflammation [79,139,140].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [79]
Citations
Cites
Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs
VANE, J. R. (1971) · Nature New Biology · doi:10.1038/newbio231232a0 · Cited by 8,605
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Host microbiota constantly control maturation and function of microglia in the CNS
Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
Inflammasomes: mechanism of action, role in disease, and therapeutics
Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283
Scheltens, P., Blennow, K., Breteler, M. M. B., de Strooper, B., Frisoni, G. B., Salloway, S., & Van der Flier, W. M. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01124-1 · Cited by 3,125
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898
Research works printed but not linked: 1
- Alzheimer A. Über eine eigenartige Erkankung der Hirnrinde. Psych genchtl Med 1907; 64: 146–8.
Cited by
Sorted by citations
Items 201–218 of 218
Ishizaka, H., Sekine, A., Naka, M., Nakano, S., Nagase, H., & Tsushima, Y. (2025) · Acta Radiologica · doi:10.1177/02841851251328261
Radiation medicine at a crossroads: a historical perspective to consider future directions
Katz, M. S., & Chalmers, A. J. (2025) · The Royal College of Radiologists Open · doi:10.1016/j.rcro.2025.100350
Anti-inflammatory Potential of Dietary Components and Benefits in Alzheimer’s Disease
Lin, G. D., Rodger, A., Malik, J., Smith, P. N., & Li, R. (2025) · Nutritional neurosciences · doi:10.1007/978-981-95-2736-6_3
Ocaranza, F. J., & Sáez, J. C. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1012583
Munawara, U., Catanzaro, M., Xu, W., Tan, C., Hirokawa, K., Bosco, N., Dumoulin, D., Khalil, A., Larbi, A., Lévesque, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14821091
Munawara, U., Catanzaro, M., Xu, W., Tan, C., Hirokawa, K., Bosco, N., Dumoulin, D., Khalil, A., Larbi, A., Lévesque, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14821085
Munawara, U., Catanzaro, M., Xu, W., Tan, C., Hirokawa, K., Bosco, N., Dumoulin, D., Khalil, A., Larbi, A., Lévesque, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14821079
Munawara, U., Catanzaro, M., Xu, W., Tan, C., Hirokawa, K., Bosco, N., Dumoulin, D., Khalil, A., Larbi, A., Lévesque, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14821082
Inflammatory Signatures and Biomarkers: The Renal-Vesical Axis in Alzheimer Progression
Kim, Y., Jung, J., Cirunduzi, A. C., Yoon, S., Bang, S., & Yang, S. (2026) · International Neurourology Journal · doi:10.5213/inj.2652008.004
Development of copper ligands for therepeutic applications
Balderrama-Martínez-Sotomayor, R. (2020) · theses.fr (ABES) · doi:10.70675/449f1d52z9b40z487cza9cczb4edaf3b75f1
Ansari, S., Khali, A., Joshi, B. C., & Uniyal, S. (2026) · Physiological Mini Reviews · doi:10.2174/0116695410415209251114033740
Pathological or preventative? Amyloid-β as an effector of innate immunity
Adesunloro, O. O., Tuckey, A. N., Audia, J. P., & Shea, A. E. (2026) · Infection and Immunity · doi:10.1128/iai.00085-26
Guruacharya, A., Härtung, T., dos Reis, R. S., Moreira, N. C. D. S., Attisano, L., Bolognin, S., Iqbal, K., & Rajbanshi, B. (2026) · Stem Cell Reports · doi:10.1016/j.stemcr.2026.103051
Metadata
- Authors
- Bolós, M., Perea, J. R., & Avila, J.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) , Valderrebollo 5 , - Madrid , Spain
- Venue
- BioMolecular Concepts
- Publisher
- Walter de Gruyter GmbH
- Published
- 2017-02-23
- Volume
- 8
- Issue
- 1
- Pages
- 37-43
- ISSN
- 1868-5021 (ISSN-L)
- 1868-503X
- OpenAlex
- W2589440020
- Cited by
- 216
- References
- 90
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 11 · 2023: 18 · 2022: 20 · 2021: 44 · 2020: 23 · 2019: 27 · 2018: 34 · 2017: 15
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMolecular Concepts (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, neuroinflammation, microglia, amyloid plaques, tau hyperphosphorylation, neurodegeneration, dementia, neuronal cell death
- MeSH terms
- Alzheimer Disease, Animals, Humans, Inflammation, tau Proteins, Microglia, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
