Cited by 218Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

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Alzheimer’s disease as an inflammatory disease

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Bolós, Marta, Perea, Juan Ramón, Avila, Jesús·2017·BioMolecular Concepts

DOI 10.1515/bmc-2016-0029

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Abstract

Alzheimer's disease (AD) is a neurodegenerative condition characterized by the formation of amyloid-β plaques, aggregated and hyperphosphorylated tau protein, activated microglia and neuronal cell death, ultimately leading to progressive dementia. In this short review, we focus on neuroinflammation in AD. Specifically, we describe the participation of microglia, as well as other factors that may contribute to inflammation, in neurodegeneration.

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Alzheimer A. Über eine eigenartige Erkankung der Hirnrinde. Psych genchtl Med 1907; 64: 146–8.

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Alzheimer’s disease hypothesis and related therapies
Du, X., Wang, X., & Geng, M. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0107-y · Cited by 623
The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.
Ramirez, A. I., de Hoz, R., Salobrar-Garcia, E., Salazar, J. J., Rojas, B., Ajoy, D., López-Cuenca, I., Rojas, P., Triviño, A., & Ramírez, J. M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00214 · Cited by 466
Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus
Zhao, Y., Jaber, V., & Lukiw, W. J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00318 · Cited by 379
The integration of inflammaging in age-related diseases
Fülöp, T., Witkowski, J. M., Olivieri, F., & Larbi, A. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.09.003 · Cited by 368
Role of Amyloid-β and Tau Proteins in Alzheimer’s Disease: Confuting the Amyloid Cascade
Gulisano, W., Maugeri, D., Baltrons, M. A., Fà, M., Amato, A., Palmeri, A., D’Adamio, L., Grassi, C., Devanand, D. P., Honig, L. S., et al. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179935 · Cited by 313

See all 218

Authors: Bolós, M., Perea, J. R., & Avila, J.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) , Valderrebollo 5 , - Madrid , Spain
ORCID: Bolós, Marta
Perea, Juan Ramón
Venue: BioMolecular Concepts
Publisher: Walter de Gruyter GmbH
Published: 2017-02-23
Volume: 8
Issue: 1
Pages: 37-43
ISSN: 1868-5021 (ISSN-L)
1868-503X
DOI: 10.1515/bmc-2016-0029
OpenAlex: W2589440020
Cited by: 216
References: 90
Citations by year: 2026: 7 · 2025: 17 · 2024: 11 · 2023: 18 · 2022: 20 · 2021: 44 · 2020: 23 · 2019: 27 · 2018: 34 · 2017: 15
FWCI: 2.60
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (unspecified)
Locations: BioMolecular Concepts (publishedVersion, cc-by)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: Alzheimer's disease, neuroinflammation, microglia, amyloid plaques, tau hyperphosphorylation, neurodegeneration, dementia, neuronal cell death
MeSH terms: Alzheimer Disease, Animals, Humans, Inflammation, tau Proteins, Microglia, Neurodegenerative Diseases

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Alzheimer’s disease as an inflammatory disease

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