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Alzheimer’s disease as an inflammatory disease
Open accessAbstract
Alzheimer's disease (AD) is a neurodegenerative condition characterized by the formation of amyloid-β plaques, aggregated and hyperphosphorylated tau protein, activated microglia and neuronal cell death, ultimately leading to progressive dementia. In this short review, we focus on neuroinflammation in AD. Specifically, we describe the participation of microglia, as well as other factors that may contribute to inflammation, in neurodegeneration.
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“Persistent activation of microglia and astrocytes elevates inflammatory mediators like chemokines and cytokines [79], the ROS and RNS release, with neurotoxic effects and responsible for chronic neurological/neurodegenerative disorders [80,81,82].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [79]
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“In AD, the increase in soluble Aβ oligomeric species, aggregated Aβ plaques and neurofibrillary tangles of hyperphosphorylated Tau proteins leads to activation of microglia and thus to neuroinflammation [79,139,140].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [79]
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Metadata
- Authors
- Bolós, M., Perea, J. R., & Avila, J.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) , Valderrebollo 5 , - Madrid , Spain
- Venue
- BioMolecular Concepts
- Publisher
- Walter de Gruyter GmbH
- Published
- 2017-02-23
- Volume
- 8
- Issue
- 1
- Pages
- 37-43
- ISSN
- 1868-5021 (ISSN-L)
- 1868-503X
- OpenAlex
- W2589440020
- Cited by
- 216
- References
- 90
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 11 · 2023: 18 · 2022: 20 · 2021: 44 · 2020: 23 · 2019: 27 · 2018: 34 · 2017: 15
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMolecular Concepts (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, neuroinflammation, microglia, amyloid plaques, tau hyperphosphorylation, neurodegeneration, dementia, neuronal cell death
- MeSH terms
- Alzheimer Disease, Animals, Humans, Inflammation, tau Proteins, Microglia, Neurodegenerative Diseases
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