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Cited by 5Clinical Laboratory Practices and Quality ControlBlood Coagulation and Thrombosis MechanismsTrauma, Hemostasis, Coagulopathy, Resuscitation

Arterial and venous blood sampling is equally applicable for coagulation and fibrinolysis analyses

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Christensen, Silje Hovden, Nissen, Peter Henrik, Hjørnet, Niels Eykens, Greisen, Jacob Raben, Hvas, Anne-Mette·2022·Clinical Chemistry and Laboratory Medicine (CCLM)
DOI 10.1515/cclm-2022-0567
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Abstract

Objectives: No consensus exists upon whether arterial and venous blood samples are equivalent when it comes to coagulation analyses. We therefore conducted a comparative cohort study to clarify if arteriovenous differences affect analyses of primary and secondary hemostasis as well as fibrinolysis. Methods: Simultaneous paired blood samplings were obtained from a cannula in the radial artery and an antecubital venipuncture in 100 patients immediately before or one day after thoracic surgery. Analyses of platelet count and aggregation, International Normalized Ratio (INR), activated partial thromboplastin time (APTT), antithrombin, thrombin time, fibrinogen, D-dimer, rotational thromboelastometry (ROTEM), thrombin generation, prothrombin fragment 1 + 2, and an in-house dynamic fibrin clot formation and lysis assay were performed. Results: No differences were found between arterial and venous samples for the far majority of parameters. The only differences were found in INR, median (IQR): venous, 1.1 (0.2) vs. arterial, 1.1 (0.2) (p<0.002) and in prothrombin fragment 1 + 2: venous, 289 (209) pmol/L vs. arterial, 279 (191) pmol/L (p<0.002). Conclusions: The sampling site does not affect the majority of coagulation analyses. Small differences were found for two parameters. Due to numerically very discrete differences, they are of no clinical relevance. In conclusion, the present data suggest that both samples obtained from arterial and venous blood may be applied for analyses of coagulation and fibrinolysis.

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  • Eight studies with 986 adult patients examined external jugular venipuncture in extreme DVA cases.

    “Eight studies with 986 adult patients [11] examined external jugular venipuncture in extreme DVA cases.”

    From Strategies to Address Difficult Venous Access in Blood Sampling: A Comprehensive Meta-Analysis (2026) · cites this paper as [11]

    The Abstract describes one comparative cohort study of 100 patients, not eight studies involving 986 patients. The Blood sampling section specifies antecubital venipuncture and radial-artery cannulation, rather than external jugular venipuncture in extreme DVA cases. (LLM, conf=0.90)

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Research works printed but not linked: 3

  1. [11]11. Woller T, Lawall H, Amann B, Angelkort B. Comparison of haemostatic parameters in arterial and venous blood from patients with peripheral arterial occlusive disease. Vasa 1999; 28:10-4.
  2. [25]25. Hering J, Amann B, Angelkort B, Rottmann M. Thrombin- antithrombin complex and the prothrombin fragment in arterial and venous blood of patients with peripheral arterial disease. Vasa 2003;32:193-7.
  3. [33]33. McLaren G, Hanna C, Mills L, Bourdeau J, Cowin R. Comparison of sampling methods for obtaining accurate coagulation values in hemodialysis patients with heparinized central venous catheters. Nephrol Nurs J 2001;28:632-6.

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Authors
Christensen, S. H., Nissen, P. H., Hjørnet, N. E., Greisen, J. R., & Hvas, A.-M.
Affiliations
  • Aarhus University Hospital (DK)
  • Aarhus University (DK)
Corresponding author
Nissen, Peter Henrik
ORCID
Venue
Clinical Chemistry and Laboratory Medicine (CCLM)
Publisher
Walter de Gruyter GmbH
Published
2022-08-10
Volume
60
Issue
11
Pages
1847-1854
ISSN
  • 1434-6621 (ISSN-L)
  • 1437-4331
DOI
10.1515/cclm-2022-0567
OpenAlex
W4298087231
Semantic Scholar
b7a7a15c160a9cac1340d32d0dce33e76f63ba00
Cited by
5
References
36
Citations by year
2026: 4 · 2022: 1
FWCI
0.15
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Clinical Chemistry and Laboratory Medicine (CCLM) (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Aarhus Universitet
  • Aarhus Universitetshospital
Topics
  • Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
Keywords
arterial blood sampling, venous blood sampling, coagulation analysis, fibrinolysis, primary hemostasis, secondary hemostasis, thoracic surgery, prothrombin fragment 1+2, D-dimer, rotational thromboelastometry, thrombin generation, platelet aggregation, international normalized ratio, antithrombin III, fibrinogen
MeSH terms
Antithrombins, Blood Coagulation Tests, Fibrin, Fibrinogen, Fibrinolysis, Humans, Partial Thromboplastin Time, Thrombelastography, Thrombin, Cohort Studies, Phlebotomy

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