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The IFCC recommendation on estimation of reference intervals. The RefVal Program
Abstract
The International Federation of Clinical Chemistry (IFCC) published between 1987--91 a series of six recommendations on reference values in laboratory medicine. This paper reviews the history and scope of the fifth part of these recommendations. This fifth recommendation deals with statistical methods used for analysis of reference values and estimation of reference intervals. The RefVal program, which implements the recommended method, is also described.
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“However, the study was too small to be a normal reference guide because the International Federation of Clinical Chemistry and Laboratory Medicine has recommended a minimum sample size of 120 to determine normal reference ranges.131”
From Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility. (2023) · cites this paper as [131]
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“the International Federation of Clinical Chemistry and Laboratory Medicine has recommended a minimum sample size of 120 to determine normal reference ranges.131”
From Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility. (2023) · cites this paper as [131]
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Metadata
- Authors
- Solberg, H. E.
- Affiliations
- Oslo University Hospital (NO)
- Corresponding author
- Solberg, Helge Erik
- Venue
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Publisher
- Walter de Gruyter GmbH
- Published
- 2004-01-05
- Volume
- 42
- Issue
- 7
- Pages
- 710-4
- ISSN
- 1434-6621 (ISSN-L)
- 1437-4331
- OpenAlex
- W2062343814
- Cited by
- 258
- References
- 6
- Citations by year
- 2026: 14 · 2025: 6 · 2024: 7 · 2023: 12 · 2022: 15 · 2021: 11 · 2020: 9 · 2019: 16 · 2018: 19 · 2017: 12 · 2016: 9 · 2015: 13 · 2014: 11 · 2013: 14 · 2012: 11
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Chemistry and Laboratory Medicine (CCLM) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
- Physical Sciences › Physics and Astronomy › Instrumentation › Scientific Measurement and Uncertainty Evaluation
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
- Keywords
- reference values, IFCC recommendations, clinical pathology
- MeSH terms
- Chemistry, Clinical, Data Interpretation, Statistical, Humans, Reference Values, Practice Guidelines as Topic, Clinical Chemistry Tests
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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