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Cited by 92Effects and risks of endocrine disrupting chemicalsToxic Organic Pollutants ImpactPolymer Science and PVC

Time-trends in human urinary concentrations of phthalates and substitutes DEHT and DINCH in Asian and North American countries (2009-2019)

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Domínguez-Romero, Elena, Komprdová, Klára, Kalina, Jiří, Bessems, Jos, Karakitsios, Spyros, Sarigiannis, Dimosthenis A., Scheringer, Martin·2023·Journal of Exposure Science & Environmental Epidemiology
DOI 10.1038/s41370-022-00441-wPMC PMC10005949
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Abstract

Background: Many phthalates are environmental pollutants and toxic to humans. Following phthalate regulations, human exposure to phthalates has globally decreased with time in European countries, the US and Korea. Conversely, exposure to their substitutes DEHT and/or DINCH has increased. In other countries, including China, little is known on the time-trends in human exposure to these plasticizers. Objective: We aimed to estimate time-trends in the urinary concentrations of phthalates, DEHT, and DINCH metabolites, in general population from non-European countries, in the last decade. Methods: We compiled human biomonitoring (HBM) data from 123 studies worldwide in a database termed “PhthaLit”. We analyzed time-trends in the urinary concentrations of the excreted metabolites of various phthalates as well as DEHT and DINCH per metabolite, age group, and country/region, in 2009–2019. Additionally, we compared urinary metabolites levels between continents. Results: We found solid time-trends in adults and/or children from the US, Canada, China and Taiwan. DEHP metabolites decreased in the US and Canada. Conversely in Asia, 5oxo- and 5OH-MEHP (DEHP metabolites) increased in Chinese children. For low-weight phthalates, the trends showed a mixed picture between metabolites and countries. Notably, MnBP (a DnBP metabolite) increased in China. The phthalate substitutes DEHT and DINCH markedly increased in the US. Significance: We addressed the major question of time-trends in human exposure to phthalates and their substitutes and compared the results in different countries worldwide. Impact: Phthalates account for more than 50% of the plasticizer world market. Because of their toxicity, some phthalates have been regulated. In turn, the consumption of non-phthalate substitutes, such as DEHT and DINCH, is growing. Currently, phthalates and their substitutes show high detection percentages in human urine. Concerning time-trends, several studies, mainly in Europe, show a global decrease in phthalate exposure, and an increase in the exposure to phthalate substitutes in the last decade. In this study, we address the important question of time-trends in human exposure to phthalates and their substitutes and compare the results in different countries worldwide.

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  • Mixtures of industrial chemical residues are commonly present in the blood and urine of diverse populations.

    “Multiple biomonitoring studies have found that mixtures of industrial chemical residues are commonly present in the blood and urine of diverse populations (Crinnion, 2010; Porta et al., 2008; Dominguez-Romero et al., 2023; Tkalec et al., 2022; Woodruff et al., 2011).”

    From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Dominguez-Romero et al., 2023

    The Introduction (page unavailable) reports that phthalates were detected in more than 90% of urine samples from general populations in Asian, European, and North American countries. The paper also analyzes urinary metabolites of several phthalates and substitutes, but it does not establish that mixtures of industrial chemical residues are commonly present in blood. (LLM, conf=0.88)

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Authors
Domínguez-Romero, E., Komprdová, K., Kalina, J., Bessems, J., Karakitsios, S., Sarigiannis, D. A., & Scheringer, M.
Affiliations
  • Masaryk University (CZ)
  • Flemish Institute for Technological Research (BE)
  • Aristotle University of Thessaloniki (GR)
Corresponding author
Domínguez-Romero, Elena
ORCID
Venue
Journal of Exposure Science & Environmental Epidemiology
Publisher
Springer Science and Business Media LLC
Published
2022-05-05
Volume
33
Issue
2
Pages
244-254
ISSN
  • 1559-0631 (ISSN-L)
  • 1559-064X
DOI
10.1038/s41370-022-00441-w
PMC
PMC10005949
OpenAlex
W4229008525
Cited by
92
References
5
Citations by year
2026: 21 · 2025: 24 · 2024: 30 · 2023: 15 · 2022: 2
FWCI
6.97
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Exposure Science & Environmental Epidemiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Veřejné služby Informačního systému (Masarykiana Brunensis Universitas) (submittedVersion, cc-by)
Funders
  • European Commission (733032, 857560, CZ.02.1.01/0.0/0.0/15_003/0000469, CZ.02.1.01, HORIZON2020, CZ.02.1.01/0.0/0.0/17_043/0009632, HBM4EU project, LM2018121)
  • RECETOX Přírodovědecké Fakulty Masarykovy Univerzity (CZ.02.1.01/0.0/0.0/17_043/0009632, LM2018121, CZ.02.1.01/0.0/0.0/15_003/0000469, 857560)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Physical Sciences › Materials Science › Polymers and Plastics › Polymer Science and PVC
Keywords
phthalates, DINCH, plasticizers, temporal trends, urinary metabolites, human exposure, DEHP metabolites, Asia, North America, China, children
MeSH terms
Adult, Child, Diethylhexyl Phthalate, Environmental Exposure, Environmental Pollutants, Humans, North America, Phthalic Acids, Plasticizers

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