Biochemical reference intervals for sex hormones with a new AutoDelfia method in aged men
Abstract
Our aim was to establish sex hormone reference intervals measured with a new AutoDelfia immunoassay method for aged men free of medication and/or conditions known to influence sex hormone levels. The reference population consisted of 466 individuals between 64 and 97 years (mean 72 years) and a mean body mass index (BMI) of 26.9 kg/m Because age correlated significantly with most sex hormones studied, we calculated reference intervals for three age groups (64–69, 70–74 and ≥75 years). In clinical practice, single ranges can be used for men aged 64 years or over for testosterone, estradiol and follicle-stimulating hormone (FSH) with the AutoDelfia method. For free testosterone and luteinizing hormone (LH), separate reference intervals should be used for men aged 64–74 years and those aged 75 years or over. For sex hormone-binding globulin, two separate reference intervals by age (64–69 and ≥70 years) are also needed for aged men. LH and FSH reference ranges should be judged with caution, because they may be too high due to cases of subclinical hypogonadism included in the reference population. Clin Chem Lab Med 2007;45:249–53.
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Multiple studies attempted to establish a reference range for total T in young men, ending in diverse intervals for all different cohorts.
“Multiple studies attempted to establish a reference range to achieve generally accepted values for total T in young men, ending in diverse intervals for all different cohorts [174–177].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [174]
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Vermeulen, A. (1996) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.5.1821 · Cited by 455 · see citing works
Endogenous sex hormones in men aged 40-80 years
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Leifke, E., Gorenoi, V., Wichers, C., Von Zur Mühlen, A., Von Büren, E., & Brabant, G. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01159.x · Cited by 262 · see citing works
Svartberg, J., Midtby, M., Bonaa, K., Sundsfjord, J., Joakimsen, R., & Jorde, R. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490145 · Cited by 257 · see citing works
Bjørnerem, Å., Straume, B., Midtby, M., Fønnebø, V., Sundsfjord, J., Svartberg, J., Acharya, G., Øian, P., & Berntsen, G. K. R. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0735 · Cited by 199 · see citing works
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Bhasin, S., Pencina, M., Jasuja, G. K., Travison, T. G., Coviello, A., Orwoll, E., Wang, P. Y., Nielson, C., Wu, F., Tajar, A., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-3012 · Cited by 355 · see citing works
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Narinx, N., David, K., Walravens, J., Vermeersch, P., Claessens, F., Fiers, T., Lapauw, B., Antonio, L., & Vanderschueren, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04562-1 · Cited by 96 · see citing works
- Authors
- Eskelinen, S., Vahlberg, T., Isoaho, R., Kivelä, S.-L., & Irjala, K.
- Affiliations
- University of Turku (FI)
- Turku University Hospital (FI)
- Venue
- Clinical Chemical Laboratory Medicine
- Publisher
- Walter de Gruyter GmbH
- Published
- 2007-01-01
- Volume
- 45
- Issue
- 2
- Pages
- 249-53
- ISSN
- 1434-6621 (ISSN-L)
- 1437-4331
- OpenAlex
- W2004592617
- Cited by
- 6
- References
- 5
- Citations by year
- 2022: 1 · 2018: 1 · 2017: 1 · 2015: 1
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Chemistry and Laboratory Medicine (CCLM) (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kunnanlääkäri Uulo Arhion Rahasto
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- sex hormones, reference values, testosterone, estradiol, follicle-stimulating hormone, luteinizing hormone, sex hormone-binding globulin, free testosterone, age-related changes
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Estradiol, Follicle Stimulating Hormone, Humans, Immunoassay, Male, Middle Aged, Reference Standards, Sex Hormone-Binding Globulin, Gonadal Steroid Hormones, Testosterone, Body Mass Index
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