Can pulse wave velocity (PWV) alone express arterial stiffness? A neglected tool for vascular function assessment
Abstract
Arterial stiffness, defined as the rigidity of the arterial wall, is the consequence of vascular aging and is associated with the full spectrum of cardiovascular diseases. Carotid-femoral pulse wave velocity (cf-PWV) is the gold standard method for arterial stiffness evaluation: it measures the velocity of the arterial pulse along the thoracic and abdominal aorta alongside arterial distensibility. Its value rises as stiffness progresses. Cf-PWV is helpful to assess residual cardiovascular risk (CVR) in hypertension (HT). In fact, an increase in pulsatility and arterial stiffness predicts CVR in patients affected by arterial HT, independently of other risk factors. Arterial stiffness can predict cardiovascular events in several other clinical conditions such as heart failure, diabetes, and pulmonary HT. However, cf-PWV has not been yet included in routine clinical practice so far. A possible reason might be its methodological and theoretical limitations (inaccuracy in the traveled distance, intra and interindividual variability, lack of well-defined references values, and age- and blood pressure-independent cutoff). To exceed these limits a strict adherence to guidelines, use of analytical approaches, and possibility of integrating the results with other stiffness examinations are essential approaches.
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Carotid-femoral pulse-wave velocity measured arterial stiffness, which is the gold standard.
“Carotid- femoral PWV measured arterial stiffness, which is the gold standard (27).”
From Oral inflammatory load predicts vascular function in a young adult population: a pilot study (2023) · cites this paper as [27]
Cites
2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,638 · see citing works
Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association
Virani, S. S., Alonso, A., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Delling, F. N., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000757 · Cited by 9,175 · see citing works
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001940 · Cited by 2,885 · see citing works
Arterial Stiffness and Cardiovascular Events: The Framingham Heart Study
Mitchell, G. F., Hwang, S.-J., Vasan, R. S., Larson, M. G., Pencina, M. J., Hamburg, N. M., Vita, J. A., Levy, D., & Benjamin, E. J. (2010) · Circulation · doi:10.1161/circulationaha.109.886655 · Cited by 2,225 · see citing works
The Reference Values for Arterial Stiffness' Collaboration (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq165 · Cited by 2,085 · see citing works
Bortel, L. M. V., Laurent, S., Boutouyrie, P., Chowienczyk, P., Cruickshank, J. K., Backer, T. L. M. D., Filipovský, J., Huybrechts, S. A. M., Mattace-Raso, F. U. S., Protogerou, A. D., et al. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834fa8b0 · Cited by 2,012 · see citing works
2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults
Greenland, P., Alpert, J. S., Beller, G. A., Benjamin, E. J., Budoff, M. J., Fayad, Z. A., Foster, E., Hlatky, M. A., Hodgson, J. M., Kushner, F. G., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3182051b4c · Cited by 1,968 · see citing works
Arterial Stiffness and Risk of Coronary Heart Disease and Stroke: The Rotterdam Study
Mattace-Raso, F. U. S., van der Cammen, T. J. M., Hofman, A., van Popele, N. M., Bos, M. L., Schalekamp, M. A. D. H., Asmar, R., Reneman, R. S., Hoeks, A. P. G., Breteler, M. M. B., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.555235 · Cited by 1,914 · see citing works
Willum Hansen, T., Staessen, J. A., Torp-Pedersen, C., Rasmussen, S., Thijs, L., Ibsen, H., & Jeppesen, J. (2006) · Circulation · doi:10.1161/circulationaha.105.579342 · Cited by 1,515 · see citing works
Asmar, R., Benetos, A., Topouchian, J., Laurent, P., Pannier, B., Brisac, A.-M., Target, R., & Levy, B. I. (1995) · Hypertension · doi:10.1161/01.hyp.26.3.485 · Cited by 1,376 · see citing works
Vlachopoulos, C., Aznaouridis, K., O'Rourke, M. F., Safar, M. E., Baou, K., & Stefanadis, C. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq024 · Cited by 1,363 · see citing works
2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults
Greenland, P., Alpert, J. S., Beller, G. A., Benjamin, E. J., Budoff, M. J., Fayad, Z. A., Foster, E., Hlatky, M. A., Hodgson, J. M., Kushner, F. G., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.001 · Cited by 1,322 · see citing works
Sutton-Tyrrell, K., Najjar, S. S., Boudreau, R. M., Venkitachalam, L., Kupelian, V. A., Simonsick, E. M., Havlik, R. J., Lakatta, E. G., Spurgeon, H. A., Kritchevsky, S. B., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.483628 · Cited by 1,250 · see citing works
Aortic Pulse Wave Velocity Predicts Cardiovascular Mortality in Subjects >70 Years of Age
Meaume, S., Benetos, A., Henry, O. F., Rudnichi, A., & Safar, M. E. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1201.100226 · Cited by 731 · see citing works
Vlachopoulos, C., Xaplanteris, P., Aboyans, V., Brodmann, M., Cífková, R., Cosentino, F., De Carlo, M., Gallino, A., Landmesser, U., Laurent, S., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.05.007 · Cited by 716 · see citing works
Vlachopoulos, C. V., Xaplanteris, P., Aboyans, V., Brodmann, M., Cífková, R., Cosentino, F., Carlo, M. D., Gallino, A., Landmesser, U., Laurent, S., et al. (2015) · HAL · Cited by 590 · see citing works
Pulse Pressure Not Mean Pressure Determines Cardiovascular Risk in Older Hypertensive Patients
Blacher, J., Staessen, J. A., Girerd, X. J., Gąsowski, J., Thijs, L., Liu, L., Wang, J. G., Fagard, R. H., & Safar, M. E. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.8.1085 · Cited by 580 · see citing works
Effect of Age on Brachial Artery Wall Properties Differs From the Aorta and Is Gender Dependent
Spek, J. J., Staessen, J. A., Fagard, R. H., Hoeks, A. P. G., Struijker-Boudier, H. A. J., & Bortel, L. M. V. (2000) · Hypertension · doi:10.1161/01.hyp.35.2.637 · Cited by 388 · see citing works
Methods and devices for measuring arterial compliance in humans
Pannier, B., Avolio, A. P., Hoeks, A. P. G., Mancia, G., & Takazawa, K. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(02)02962-x · Cited by 341 · see citing works
Arterial stiffness as a risk factor for clinical hypertension
Safar, M. E. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.155 · Cited by 301 · see citing works
McEniery, C. M., Yasmin, Y., Wallace, S. M. L., Maki-Petaja, K. M., McDonnell, B. J., Sharman, J. E., Retallick, C., Franklin, S. S., Brown, M. J., Lloyd, R., et al. (2005) · Hypertension · doi:10.1161/01.hyp.0000165310.84801.e0 · Cited by 284 · see citing works
Mitchell, G. F., Vita, J. A., Larson, M. G., Parise, H., Keyes, M. J., Warner, E., Vasan, R. S., Levy, D. A., & Benjamin, E. J. (2005) · Circulation · doi:10.1161/circulationaha.105.551168 · Cited by 282 · see citing works
Zhong, Q., Hu, M., Cui, Y., Liang, L., Zhou, M.-M., Yang, Y., & Huang, F. (2017) · Angiology · doi:10.1177/0003319717742544 · Cited by 214 · see citing works
Milutinović, A., Šuput, D., & Zorc‐Pleskovič, R. (2019) · Bosnian Journal of Basic Medical Sciences · doi:10.17305/bjbms.2019.4320 · Cited by 200 · see citing works
In vivo arterial compliance in man
Laogun, A. A., & Gosling, R. G. (1982) · Clinical Physics and Physiological Measurement · doi:10.1088/0143-0815/3/3/004 · Cited by 188 · see citing works
Pulse wave velocity as endpoint in large-scale intervention trial. The Complior® study
Asmar, R. G., Topouchian, J. A., Pannier, B., Bénétos, A., & Safar, M. E. (2001) · Journal of Hypertension · doi:10.1097/00004872-200104000-00019 · Cited by 151 · see citing works
Arterial Stiffness in Hypertension: an Update
Dumor, K., Shoemaker‐Moyle, M., Nistala, R., & Whaley‐Connell, A. T. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0867-x · Cited by 109 · see citing works
Arterial Stiffness and Vitamin D Levels: the Baltimore Longitudinal Study of Aging
Giallauria, F., Milaneschi, Y., Tanaka, T., Maggio, M. G., Canepa, M., Elango, P., Vigorito, C., Lakatta, E. G., Ferrucci, L., & Strait, J. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1584 · Cited by 92 · see citing works
Arterial Stiffness: Going a Step Beyond
Gavish, B., & Izzo, J. L. (2016) · American Journal of Hypertension · doi:10.1093/ajh/hpw061 · Cited by 87 · see citing works
Pandey, A., Khan, H., Newman, A. B., Lakatta, E. G., Forman, D. E., Butler, J., & Berry, J. D. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.08327 · Cited by 80 · see citing works
Arterial Stiffness and Vascular Load in Heart Failure
Ooi, H., Chung, W. B., & Biolo, A. (2008) · Congestive Heart Failure · doi:10.1111/j.1751-7133.2008.07210.x · Cited by 76 · see citing works
Arcopinto, M., Salzano, A., Giallauria, F., Bossone, E., Isgaard, J., Marra, A. M., Bobbio, E., Vriz, O., Åberg, D. N., Masarone, D., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170058 · Cited by 73 · see citing works
Brachial-Ankle Pulse Wave Velocity Is a Strong Predictor for Mortality in Patients With Acute Stroke
Kim, J., Song, T., Song, D., Lee, K. J., Kim, E. H., Lee, H. S., Nam, C. M., Nam, H. S., Kim, Y. D., & Heo, J. H. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03304 · Cited by 72 · see citing works
Giannattasio, C., & Mancia, G. (2002) · Journal of Hypertension · doi:10.1097/00004872-200210000-00001 · Cited by 70 · see citing works
Marra, A. M., Arcopinto, M., Bossone, E., Ehlken, N., Cittadini, A., & Grünig, E. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.10.005 · Cited by 64 · see citing works
The GH/IGF-1 Axis in Chronic Heart Failure
Arcopinto, M., Bobbio, E., Bossone, E., Filardi, P. P., Napoli, R., Saccà, L., & Cittadini, A. (2013) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530311313010010 · Cited by 59 · see citing works
Cerbone, M., Capalbo, D., Wasniewska, M. G., Alfano, S., Raso, G. M., Oliviero, U., Cittadini, A., Luca, F. D., & Salerno, M. (2016) · European Journal of Endocrinology · doi:10.1530/eje-15-0833 · Cited by 59 · see citing works
Marra, A. M., Halank, M., Benjamin, N., Bossone, E., Cittadini, A., Eichstaedt, C. A., Egenlauf, B., Harutyunova, S., Fischer, C., Gall, H. J., et al. (2018) · Respiratory Research · doi:10.1186/s12931-018-0957-y · Cited by 58 · see citing works
Measurement of Aortic Pulse Wave Velocity With a Connected Bathroom Scale
Campo, D., Khettab, H., Yu, R., Genain, N., Edouard, P., Buard, N., & Boutouyrie, P. (2017) · American Journal of Hypertension · doi:10.1093/ajh/hpx059 · Cited by 51 · see citing works
Multiple hormone deficiencies in chronic heart failure
Arcopinto, M., Salzano, A., Bossone, E., Ferrara, F., Bobbio, E., Sirico, D., Vriz, O., Vincentiis, C. D., Matarazzo, M., Saldamarco, L., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.02.055 · Cited by 50 · see citing works
Sharif, S., Visseren, F. L. J., Spiering, W., de Jong, P. A., Bots, M. L., Westerink, J., & on behalf of the SMART study group (2019) · Diabetic Medicine · doi:10.1111/dme.13954 · Cited by 47 · see citing works
Prediction of Cardiovascular Events With Aortic Stiffness in Patients With Erectile Dysfunction
Vlachopoulos, C. V., Ioakeimidis, N., Aznaouridis, K. A., Terentes-Printzios, D. G., Rokkas, K., Aggelis, A., Panagiotakos, D., & Stefanadis, C. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03369 · Cited by 38 · see citing works
Prognostic Value of Aortic Stiffness in Patients After ST‐Elevation Myocardial Infarction
Feistritzer, H., Klug, G., Reinstadler, S. J., Reindl, M., Niess, L., Nalbach, T., Kremser, C., Mayr, A., & Metzler, B. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.005590 · Cited by 38 · see citing works
Hormone replacement therapy in heart failure
Arcopinto, M., Salzano, A., Isgaard, J., & Cittadini, A. (2015) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000166 · Cited by 37 · see citing works
Arterial Stiffness and Bone Demineralization: The Baltimore Longitudinal Study of Aging
Giallauria, F., Ling, S. M., Schreiber, C., Maggio, M. G., Shetty, V., Muller, D., Vigorito, C., Ferrucci, L., & Najjar, S. S. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.80 · Cited by 33 · see citing works
L ong‐term effect of epoetin alfa on clinical and biochemical markers in friedreich ataxia
Saccà, F., Puorro, G., Marsili, A., Antenora, A., Pane, C., Casali, C., Marcotulli, C., Defazio, G., Liuzzi, D., Tatillo, C., et al. (2016) · Movement Disorders · doi:10.1002/mds.26552 · Cited by 32 · see citing works
Prognostic Impact of Aortic Stiffness in Patients With Resistant Hypertension
Cardoso, C. R. L., Salles, G. C., & Salles, G. F. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.12367 · Cited by 23 · see citing works
Graham, M. R. (2008) · Vascular Health and Risk Management · doi:10.2147/vhrm.s3220 · Cited by 21 · see citing works
Graham, M. R., Evans, P., Thomas, N. E., Davies, B., & Baker, J. S. (2009) · American Journal of Cardiovascular Drugs · doi:10.2165/11312100-000000000-00000 · Cited by 15 · see citing works
Systemic Arterial Stiffness in New Diagnosed Idiopathic Pulmonary Arterial Hypertension Patients
Radchenko, G., Zhyvylo, I., Titov, E. Y., & Sirenko, Y. (2020) · Vascular Health and Risk Management · doi:10.2147/vhrm.s230041 · Cited by 12 · see citing works
Ye, P., Wang, X., Cao, R., Xu, Y., Xiao, W., Zhang, Y., Bai, Y., Wu, H., & Han, J. (2016) · Clinical Interventions in Aging · doi:10.2147/cia.s109009 · Cited by 8 · see citing works
Management of patients with chronic heart failure and type 2 diabetes mellitus: the SCODIAC-II study
Luca, M. D., Bosso, G., Valvano, A., Guardasole, V., Botta, A., Carbone, V., Carella, G., Buono, A. D., Giovanni, G. D., Fimiani, B., et al. (2020) · Internal and Emergency Medicine · doi:10.1007/s11739-020-02528-4 · Cited by 8 · see citing works
Bosso, G., Luca, M. D., & Oliviero, U. (2021) · Minerva Cardiology and Angiology · doi:10.23736/s2724-5683.20.05314-1 · Cited by 2 · see citing works
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“Carotid- femoral PWV measured arterial stiffness, which is the gold standard (27).”
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- Authors
- De Luca, M., Iacono, O., Valente, V., Giardino, F., Crisci, G., Lettieri, M., Marra, A., Giallauria, F., & Oliviero, U.
- Affiliations
- Department of Translational Medical Sciences , “Federico II” University , Naples , Italy
- University of Naples Federico II (IT)
- University Hospital Heidelberg (DE)
- ORCID
- Venue
- Journal of Basic and Clinical Physiology and Pharmacology
- Publisher
- Walter de Gruyter GmbH
- Published
- 2021-07-20
- Volume
- 33
- Issue
- 4
- Pages
- 373-379
- ISSN
- 0792-6855 (ISSN-L)
- 2191-0286
- OpenAlex
- W3184399295
- Cited by
- 9
- References
- 53
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Basic and Clinical Physiology and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- arterial stiffness, carotid-femoral pulse wave velocity, vascular aging, cardiovascular risk, hypertension, arterial distensibility, vascular function assessment, reference values, cut-off values
- MeSH terms
- Aging, Blood Pressure, Humans, Hypertension, Vascular Stiffness, Pulse Wave Analysis
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