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Cited by 54Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesSexual Differentiation and DisordersHormonal and reproductive studies

Comparison of transdermal and oral estrogen therapy in girls with Turner's syndrome

Jospe, N., Orlowski, C.C., Furlanetto, R.W.·1995·Journal of Pediatric Endocrinology and Metabolism
DOI 10.1515/jpem.1995.8.2.111
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Abstract

Eight girls with Turner's syndrome were given low dose oral ethinyl estradiol or transdermal 17 beta-estradiol in order to compare the effect of the route of administration on selected markers of hepatic metabolism, and various hormonal concentrations. Oral estrogen was given at a dose of 100 ng/kg/day and transdermal estrogen via adhesive skin patch at 0.0125 mg/kg/day. The subjects received one form of estradiol for one month, and after a one month washout period, received the other form. Both oral and transdermal estradiol caused a significant decrease in FSH while only transdermal resulted in a significant decrease in LH. Oral estradiol, though not transdermal estradiol, increased serum high density lipoprotein, thyroxine binding protein and growth hormone binding protein. Urinary growth hormone excretion increased after both forms of therapy, while insulin-like growth factor-I and insulin-like growth factor binding protein-3 remained unchanged. Thus, in girls with Turner's syndrome, estrogen replacement by the transdermal route may have less deleterious effect on hepatic metabolism than oral estrogen.

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Crossref · 10.1515/jpem.1995.8.2.111

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Authors
Jospe, N., Orlowski, C. C., & Furlanetto, R. W.
Affiliations
University of Rochester Medicine (US)
Venue
Journal of Pediatric Endocrinology and Metabolism
Publisher
Walter de Gruyter GmbH
Published
1995-01
Volume
8
Issue
2
Pages
111-6
ISSN
  • 0334-018X (ISSN-L)
  • 2191-0251
DOI
10.1515/jpem.1995.8.2.111
OpenAlex
W2321098202
Cited by
54
References
19
Citations by year
2024: 1 · 2023: 2 · 2022: 3 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 1
FWCI
0.42
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Pediatric Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Center for Research Resources (RR-00044, M01RR000044)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
Turner syndrome, transdermal estrogen, oral estrogen, ethinyl estradiol, estradiol, estrogen replacement therapy, route of administration, hepatic metabolism, follicle-stimulating hormone, luteinizing hormone, HDL cholesterol, thyroxine-binding proteins, growth hormone binding protein, insulin-like growth factor I, insulin-like growth factor binding protein-3, girls
MeSH terms
Administration, Cutaneous, Administration, Oral, Adolescent, Carrier Proteins, Child, Estradiol, Ethinyl Estradiol, Female, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Lipids, Lipoproteins, HDL, Growth Hormone, Thyroxine-Binding Proteins, Turner Syndrome

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