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Cited by 65Growth Hormone and Insulin-like Growth FactorsGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesHormonal and reproductive studies

Metabolic effects of oral versus transdermal estrogen in growth hormone-treated girls with Turner syndrome

Mauras, Nelly, Shulman, Dorothy, Hsiang, Helen Y., Balagopal, Prabhakaran, Welch, Susan·2007·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2007-0671
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Abstract

BACKGROUND: Transdermal (TD) estrogen is often preferred over the oral route in postmenopausal and GH-deficient women taking estrogen, but this has not been studied in detail in girls. OBJECTIVE: Our objective was to study the metabolic effects of oral vs. TD estrogen in GH-treated girls with Turner syndrome. DESIGN AND METHODS: Eleven girls with Turner syndrome, mean age 13.4 +/- 0.5 (se) yr, on GH for at least 6 months were recruited. Studies included [(13)C]leucine and d5-glycerol infusions, indirect calorimetry, dual-emission x-ray absorptiometry, and hormone and substrate measurements. They received, in random order, 17beta-estradiol orally (0.5, 1, and 2 mg for 2 wk each) and TD (0.025, 0.0375, and 0.05 mg for 2 wk each), and studies were repeated after each 6-wk course with 4 wk washout in between. RESULTS: Rates of whole-body protein turnover, oxidation and synthesis, lipolysis, lipid and carbohydrate oxidation, and resting energy expenditure were unaffected by either form of estrogen; nor were lipids, insulin, and fibrinogen concentrations affected. Plasma IGF-I concentrations did not change clinically significantly with either form of estrogen, despite higher estrogen concentrations after oral estrogen. Estradiol concentrations did not correlate with any variables measured. CONCLUSIONS: In GH-treated girls with Turner syndrome, neither oral nor TD estrogen adversely affected rates of protein turnover, lipolysis, and lipid oxidation rates or plasma lipids, fibrinogen, or fasting insulin concentrations. There was no clinically significant change in IGF-I concentrations after either form of estrogen. In aggregate, these data suggest that the route of delivery of estrogen does not adversely affect these metabolic effects of GH in young girls with Turner syndrome.

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Authors
Mauras, N., Shulman, D., Hsiang, H. Y., Balagopal, P., & Welch, S.
Affiliations
  • Nemours Children’s Clinic (US)
  • Johns Hopkins All Children's Hospital (US)
Corresponding author
Mauras, Nelly
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2007-11-01
Volume
92
Issue
11
Pages
4154-4160
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2007-0671
OpenAlex
W1990858220
Cited by
65
References
37
Citations by year
2025: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 1 · 2014: 5 · 2013: 4 · 2012: 4
FWCI
2.19
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
Turner syndrome, growth hormone therapy, transdermal estrogen, oral estrogen, estradiol, protein turnover, lipolysis, lipid oxidation, carbohydrate oxidation, resting energy expenditure, insulin-like growth factor I, insulin, fibrinogen
MeSH terms
Administration, Cutaneous, Administration, Oral, Adolescent, Body Composition, Body Height, Calorimetry, Indirect, Child, Preschool, Dietary Proteins, Estrogens, Female, Fibrinogen, Humans, Insulin-Like Growth Factor I, Kinetics, Lipolysis, Oxidation-Reduction, Growth Hormone, Turner Syndrome, Lipid Peroxidation, Body Mass Index, Insulin-Like Growth Factor Binding Protein 3, Carbohydrate Metabolism, Lipid Metabolism

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