Bone mineral status in children with congenital adrenal hyperplasia
Open accessAbstract
Congenital adrenal hyperplasia (CAH) is caused by a deficiency in an adrenal enzyme resulting in alterations in cortisol and aldosterone production. Bone status is affected by chronic glucocorticoid therapy and excess androgen exposure in children with CAH. This cross-sectional study enrolled participants with 21-hydroxylase deficiency from a pediatric referral center. Bone mineral density in the participants was normal when compared to age, gender and ethnicity adjusted standards, with respect to chronological age or bone age. Lean body mass was positively correlated with bone mineral content (BMC), independent of fat mass (p < 0.001). There was no significant correlation between glucocorticoid dose or serum androgen levels and skeletal endpoints. In conclusion, lean body mass appears to be an important correlate of BMC in patients with CAH. The normal bone status may be explained by the differential effects of glucocorticoids on growing bone, beneficial androgen effects, or other disease specific factors.
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Epidemiological and other studies have demonstrated that glucocorticoids cause secondary osteoporosis and increase fracture risk.
“Epidemiological and other studies have demonstrated that glucocorticoids cause secondary osteoporosis and increase fracture risk (701,702).”
From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [702]
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- Authors
- Fleischman, A., Ringelheim, J., Feldman, H. A., & Gordon, C. M.
- Affiliations
- Boston Children's Hospital (US)
- Venue
- Journal of Pediatric Endocrinology and Metabolism
- Publisher
- Walter de Gruyter GmbH
- Published
- 2007-01
- Volume
- 20
- Issue
- 2
- Pages
- 227-35
- ISSN
- 0334-018X (ISSN-L)
- 2191-0251
- PMC
- PMC3686497
- OpenAlex
- W2054398648
- Cited by
- 27
- References
- 33
- Citations by year
- 2025: 3 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2018: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Pediatric Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK040561)
- National Center for Research Resources (M01 RR2172, M01RR002172)
- NIH Clinical Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- congenital adrenal hyperplasia, 21-hydroxylase deficiency, bone mineral density, bone mineral content, lean body mass, glucocorticoid therapy, hyperandrogenism, children, bone age
- MeSH terms
- Adolescent, Adrenal Hyperplasia, Congenital, Adult, Androgens, Body Composition, Bone and Bones, Child, Cross-Sectional Studies, Female, Glucocorticoids, Humans, Male, Regression Analysis, Steroid 21-Hydroxylase, Bone Density
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