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Cited by 87Sexual Differentiation and DisordersAdrenal Hormones and DisordersBone health and osteoporosis research

Height, Bone Mineral Density and Bone Markers in Congenital Adrenal Hyperplasia

Paganini, C., Radetti, G., Livieri, C., Braga, V., Migliavacca, D., Adami, S.·2000·Hormone Research in Paediatrics
DOI 10.1159/000053253
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Abstract

Aim: To evaluate height, bone growth, areal bone mineral density (aBMD), volumetric bone mineral density (vBMD) and markers of bone turnover in a group of patients affected by congenital adrenal hyperplasia (CAH). Patients: There were 50 patients (23 males, 27 females), aged 1–28 years, affected by CAH due to 21-hydroxylase deficiency: 27 with the salt-wasting (SW); 14 with the simple virilizing (SV), and 9 with the nonclassical (NC) forms. Methods: Bone morphometry was evaluated with the metacarpal index (MI) and lumbar aBMD and vBMD (L2–L4) by dual energy X-ray absorptiometry. Serum osteocalcin was used as a marker of bone formation, while urinary cross-linked N-telopeptides of type-I collagen and free deoxypyridinoline levels were evaluated as indexes of bone resorption. Results: The height standard deviation score (SDS) was –0.41 ± 1.4 in SW patients, –0.01 ± 1.9 in SV patients, and –0.01 ± 2.3 in NC patients. There was no significant difference among groups and against zero. The MI SDS was also not different between groups and against zero.aBMD was significantly lower in the pubertal patients compared with normal values, but only when patients with the SW and SV forms were considered together (p < 0.05). vBMD was significantly reduced in all patients with the classical form. Bone markers were not different in patients and controls. Conclusion: Our study shows that normal height can be attained in CAH patients; however, an impairment in bone growth and mineralization may be found in adolescents and young adults affected by the classical form.

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Authors
Paganini, C., Radetti, G., Livieri, C., Braga, V., Migliavacca, D., & Adami, S.
Affiliations
  • Ospedale di Bolzano (IT)
  • University of Pavia (IT)
ORCID
Venue
Hormone Research in Paediatrics
Publisher
S. Karger AG
Published
2000
Volume
54
Issue
4
Pages
164-168
ISSN
  • 1663-2818 (ISSN-L)
  • 1663-2826
DOI
10.1159/000053253
OpenAlex
W2033593865
Cited by
87
References
26
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 6
FWCI
1.57
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Hormone Research in Paediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
congenital adrenal hyperplasia, 21-hydroxylase deficiency, bone mineral density, bone growth, height, bone turnover markers, osteocalcin, N-telopeptide, deoxypyridinoline, salt-wasting form, simple virilizing form, non-classical congenital adrenal hyperplasia, bone mineralization
MeSH terms
Adolescent, Adrenal Hyperplasia, Congenital, Adult, Amino Acids, Body Height, Bone Development, Bone Resorption, Child, Child, Preschool, Collagen, Female, Humans, Infant, Lumbar Vertebrae, Male, Metacarpus, Peptides, Biomarkers, Absorptiometry, Photon, Bone Density, Osteocalcin, Collagen Type I

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