Relationship between various maternal conditions and lactic acid dehydrogenase activity in umbilical cord blood at birth
Abstract
BACKGROUND: Lactic acid dehydrogenase (LDH) is a valuable marker for some of the most important diseases in newborns and the plasma LDH activity in newborns correlates well with conditions such as asphyxia. If LDH should be considered as a useful tool also in obstetric care, key factors associated with maternal health before and during pregnancy which could affect umbilical cord LDH activity need to be known. The aims of this study were to explore relationships between selected maternal conditions and arterial lactic acid dehydrogenase activity (aLDH) in umbilical cord blood at delivery. METHODS: A prospective observational study was conducted at Sodersjukhuset, Stockholm, Sweden. Included in the study were 1247 deliveries, and cord blood samples from each were analyzed for aLDH. Background, delivery and neonatal data were collected from the medical records. RESULTS: Higher median values of aLDH were found (P=0.001) among women with chronic disorders not related to pregnancy but there was no increased frequency of high aLDH levels (>612 μ/L, P=0.30). No difference in aLDH was identified between infants born to women with pregnancy-related disorders compared with healthy women, neither in median values, nor in high values (>612 μ/L, P=0.95). CONCLUSION: Newborn infants born to women with non-pregnancy-related chronic disorders had a somewhat higher median value of aLDH in cord blood at delivery. The influence of common maternal conditions and diseases on umbilical cord arterial LDH levels is small compared to the increase reported in fetal distress and several other critical conditions in the newborn.
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Studies reporting median LDH values but not distribution data are insufficient as normative references.
“Some studies have reported median LDH values but not distribution data, 132,133 making them insufficient as normative references.”
From Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility. (2023) · cites this paper as [132]
Among women with chronic disorders, median cord artery LDH values were significantly higher than among healthy women, but the proportion of values >612 U/L was not significantly increased.
“Significantly higher median LDH values were found among women with chronic disorders (diabetes mellitus, endocrine disease, epilepsy, kidney disease, essential hypertension, asthma) than among healthy women, but the proportion of values >612 U/L was not significantly increased.”
From Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility. (2023) · cites this paper as [132]
No difference in cord artery LDH was found between healthy women and women with pregnancy-related disorders.
“No difference in cord artery LDH was found between healthy women and women with pregnancy-related disorders.”
From Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility. (2023) · cites this paper as [132]
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- Authors
- Patavoukas, E., Åberg-Liesaho, J., Halvorsen, C. P., Winbladh, B., & Wiberg-Itzel, E.
- Affiliations
- Karolinska Institutet (SE)
- Venue
- Journal of Perinatal Medicine
- Publisher
- Walter de Gruyter GmbH
- Published
- 2018-08-28
- Volume
- 46
- Issue
- 6
- Pages
- 605-611
- ISSN
- 0300-5577 (ISSN-L)
- 1619-3997
- OpenAlex
- W2885922182
- Cited by
- 6
- References
- 17
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 2
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Perinatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hort Innovation
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- lactate dehydrogenase, umbilical cord blood, maternal condition, pregnancy disorders, fetal asphyxia, neonatal biomarkers
- MeSH terms
- Maternal Health, Adolescent, Adult, Chronic Disease, Female, Fetal Blood, Fetal Distress, Hemolysis, Humans, Infant, Newborn, L-Lactate Dehydrogenase, Male, Middle Aged, Pregnancy, Pregnancy Complications, Prospective Studies, Reference Values, Risk Factors, Sweden, Young Adult
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