Lactate dehydrogenase predicts hypoxic ischaemic encephalopathy in newborn infants: a preliminary study
Abstract
BACKGROUND: Enzyme leakage as a result of hypoxia-ischaemia induced cell damage in affected organs is seen together with hypoxic ischaemic encephalopathy (HIE) after perinatal asphyxia. AIM: To investigate whether plasma lactate dehydrogenase [LDH], alanine aminotransferase [ALT] and aspartate aminotransferase [AST] during the first 12 h after birth predict HIE and adverse neurodevelopment outcome in newborn term infants with intra-partum signs of foetal distress. METHODS: Enzymes were measured within 12 h post partum in newborn infants with differing degree of HIE (n = 41) and in infants with signs of foetal distress during birth (n = 205) without HIE (non-HIE group). All infants were randomized into two groups. One group (n = 123) was used for calculation of cut off limits for the enzymes studied and the other group (n = 123) was used for calculation of the predictive value of the enzymes for detection of HIE. RESULTS: Using ROC curves, a cut off level of 1049 U/L for [LDH] was the best predictor of HIE (sensitivity 100% and specificity 97%) but also for long term outcome after HIE. CONCLUSION: [LDH] is a good predictor of HIE during the first 12 h after birth. This result is of clinical interest offering a potential inexpensive and safe prognostic marker in newborn infants with perinatal asphyxia.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
LDH determined early in the course has low or no predictive value.
“temporal blood sampling studies 124,127 indicate that LDH determined early in the course has low or no predictive value.”
From Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility. (2023) · cites this paper as [127]
Cites
4 million neonatal deaths: When? Where? Why?
Lawn, J. E., Cousens, S., & Zupan, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71048-5 · Cited by 3,670 · see citing works
Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy
Shankaran, S., Laptook, A. R., Ehrenkranz, R. A., Tyson, J. E., McDonald, S. A., Donovan, E. F., Fanaroff, A. A., Poole, W. K., Wright, L. L., Higgins, R. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmcps050929 · Cited by 2,862 · see citing works
Gluckman, P. D., Wyatt, J. S., Azzopardi, D., Ballard, R., Edwards, A. D., Ferriero, D. M., Polin, R. A., Robertson, C. M., Thoresen, M., Whitelaw, A., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17946-x · Cited by 2,270 · see citing works
Self-citationModerate Hypothermia to Treat Perinatal Asphyxial Encephalopathy
Azzopardi, D., Strohm, B., Edwards, A. D., Dyet, L. E., Halliday, H. L., Juszczak, E., Kapellou, O., Levene, M. I., Marlow, N., Porter, E., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0900854 · Cited by 1,715 · see citing works
Self-citationEffective Care of the Newborn Infant
Speidel, B. D. (1992) · Archives of Disease in Childhood · doi:10.1136/adc.67.11.1415-a · Cited by 553 · see citing works
4 million neonatal deaths: When? Where? Why? Neonatal survival 1.
Je, L., Cousens, S., & Zupan, J. (2005) · The Lancet · Cited by 507 · see citing works
Ischemic hepatitis: clinical presentation and pathogenesis
Seeto, R. K., Fenn, B., & Rockey, D. C. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00461-7 · Cited by 361 · see citing works
Whole-Body Hypothermia for Neonates With Hypoxic???Ischemic Encephalopathy
Shankaran, S., Laptook, A. R., Ehrenkranz, R. A., Tyson, J. E., McDonald, S. A., Donovan, E. F., Fanaroff, A. A., Poole, W. K., Wright, L. L., Higgins, R. D., et al. (2006) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000201910.42613.6c · Cited by 357 · see citing works
Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy
Azzopardi, D., Strohm, B., Edwards, A. D., Dyet, L. E., Halliday, H. L., Juszczak, E., Kapellou, O., Levene, M. I., Marlow, N., Porter, E., et al. (2010) · Obstetric Anesthesia Digest · doi:10.1097/01.aoa.0000386835.73621.bb · Cited by 304 · see citing works
Self-citationCOMPARISON OF TWO METHODS OF PREDICTING OUTCOME IN PERINATAL ASPHYXIA
Levene, M. I., Grindulis, H., Sands, C., & Moore, J. R. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90718-x · Cited by 295 · see citing works
Clinical use of serum enzymes in liver disease
Reichling, J. J., & Kaplan, M. M. (1988) · Digestive Diseases and Sciences · doi:10.1007/bf01535953 · Cited by 275 · see citing works
Dynamics of fetal circulatory responses to hypoxia and asphyxia
Jensen, A., Garnier, Y., & Berger, R. E. (1999) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(98)00325-x · Cited by 207 · see citing works
Cerebral hypothermia for prevention of brain injury following perinatal asphyxia
Gunn, A. J. (2000) · Current Opinion in Pediatrics · doi:10.1097/00008480-200004000-00004 · Cited by 185 · see citing works
Aspartate aminotransferase activity and isoenzyme proportions in human liver tissues.
Rej, R. (1978) · Clinical Chemistry · doi:10.1093/clinchem/24.11.1971 · Cited by 179 · see citing works
ISCHEMIC HEPATITIS: CLINICAL FEATURES, DIAGNOSIS AND PROGNOSIS
Gibson, P. G., & Dudley, F. J. (1984) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1984.tb03780.x · Cited by 178 · see citing works
Resuscitation at birth and cognition at 8 years of age: a cohort study
Odd, D., Lewis, G., Whitelaw, A., & Gunnell, D. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60244-0 · Cited by 132 · see citing works
Arginine vasopressin mediates cardiovascular responses to hypoxemia in fetal sheep
Pérez, R., Espinoza, M., Riquelme, R. A., et al. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.256.5.r1011 · Cited by 81 · see citing works
Moderate neonatal encephalopathy: Pre‐ and perinatal risk factors and long‐term outcome
Lindström, K., Hallberg, B., Blennow, M., et al. (2008) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1080/00016340801996622 · Cited by 73 · see citing works
Self-citationKarlsson, M., Tooley, J., Šatas, S., Hobbs, C., Chakkarapani, E., Stone, J., Porter, H. J., & Thoresen, M. (2008) · Pediatric Research · doi:10.1203/pdr.0b013e318174efdd · Cited by 63 · see citing works
Self-citationDynamics of hepatic enzyme activity following birth asphyxia
Karlsson, M., Blennow, M., Németh, A., & Winbladh, B. (2006) · Acta paediatrica · doi:10.1080/08035250600693488 · Cited by 59 · see citing works
Self-citationPicard, R. R., & Berk, K. N. (1990) · The American Statistician · doi:10.2307/2684155 · Cited by 54 · see citing works
Reddy, S., Dutta, S., & Narang, A. (2008) · PubMed · Cited by 49 · see citing works
Lackmann, G. M., Töllner, U., & Mader, R. (1993) · Enzyme and Protein · doi:10.1159/000468672 · Cited by 47 · see citing works
Zanardo, V., Bondio, M., Perini, G., et al. (2009) · Biology of the Neonate · doi:10.1159/000242092 · Cited by 34 · see citing works
Lackmann, G., & Töllner, U. (1995) · Neuropediatrics · doi:10.1055/s-2007-979752 · Cited by 31 · see citing works
Reference values for selected enzyme activities in serum from healthy human neonates
Lackmann, G. M. (1996) · Clinical Biochemistry · doi:10.1016/s0009-9120(96)00103-8 · Cited by 17 · see citing works
Verspyck (1999) · doi:10.1002/(sici)1097-0223(199903)19:3
Flagged first, then by citations
Cited by
Sorted by citations
Olofsson, P. (2023) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2022.07.001 · Cited by 104 · see citing works
Patavoukas, E., Åberg-Liesaho, J., Halvorsen, C. P., Winbladh, B., & Wiberg-Itzel, E. (2018) · Journal of Perinatal Medicine · doi:10.1515/jpm-2017-0044 · Cited by 6 · see citing works
Self-citationLactic dehydrogenase in umbilical cord blood in healthy infants after different modes of delivery
Wiberg-Itzel, E., Josephson, H., Wiberg, N., Olson, L., Winbladh, B., & Karlsson, M. (2015) · Journal of Neonatal Biology · doi:10.4172/2167-0897.1000204 · Cited by 6 · see citing works
“Lactate Dehydrogenase (LDH) increases early in newborns in several critical conditions, and the LDH activity correlates well with the severity of diseases such as asphyxia [1-4] respiratory distress and Necrotizing Enterocolitis (NEC).”
Self-citation
- Authors
- Karlsson, M., Wiberg‐Itzel, E., Chakkarapani, E., Blennow, M., Winbladh, B., & Thoresen, M.
- Affiliations
- Karolinska Institutet (SE)
- University of Bristol (GB)
- Corresponding author
- Karlsson, Mathias
- Venue
- Acta Paediatrica
- Publisher
- Wiley
- Published
- 2010-07
- Volume
- 99
- Issue
- 8
- Pages
- 1139-1144
- ISSN
- 0365-1436 (ISSN-L)
- 0803-5253
- 1651-2227
- OpenAlex
- W1919350682
- Cited by
- 78
- References
- 27
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 12 · 2020: 6 · 2019: 1 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 3
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Paediatrica (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion)
- Funders
- Sparks (05/BTL/01)
- Hort Innovation
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Keywords
- hypoxic-ischemic encephalopathy, lactate dehydrogenase, perinatal asphyxia, neonatal biomarkers, prognostic factors, fetal distress, alanine aminotransferase, aspartate aminotransferase, neurodevelopmental outcomes, term infants
- MeSH terms
- Alanine Transaminase, Aspartate Aminotransferases, Developmental Disabilities, Female, Humans, Infant, Newborn, L-Lactate Dehydrogenase, Male, Predictive Value of Tests, Prognosis, ROC Curve, Sensitivity and Specificity, Severity of Illness Index, Biomarkers, Hypoxia-Ischemia, Brain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
