Diazepam elimination in premature and full term infants, and children
Open accessAbstract
In recent years a considerable amount of data have been produced on the activity of the microsomal drug metabolizing Systems in the human fetus [10,16,17,18,19,21,26,29,32].They all indicate that the various metabolic Systems responsible for drug degradation are already present in the intrauterine life, though their specific activity is in most cases considerably lower than that of adult Standards."In vitro" data, while certainly necessary, do not provide an exact index of the rate of "in vivo" metabolism and therefore the Information which can be derived is not easily applicable to clinical Problems.In fact drug effects are also determined by other factors, such äs absorption rate, plasma protein binding, tissue distribution and excretion rate.All these factors vary both with age and physiopathological Status [21,26].For this reason studies and observations on newborn infants provide further useful Information, which can eventually be applied to everyday practice.Most of the data currently available on drug kinetics and metabolism in the newborn infant concern antibiotic and sulfonamide compounds [8,11,23,24,26,27,28] though some observations have also been carried out with other drugs [13,14,21,22,30,31].In most cases they indicate a slower disposition of the drug äs compared to children.No data on the metabolic disposition of benzodiazepines in the newborn infant have been available up to now, despite the fact that this class of drug is widely administered during Curriculum vitae P. L. MORSELLI, was born in Bergamo (Italy) 1937.
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Infants have reduced hydroxylation metabolism, resulting in decreased diazepam clearance.
“Infants have reduced hydroxylation metabolism, which results in a decreased clearance of diazepam (68).”
From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [68]
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Cites
METABOLISM OF DIAZEPAM IN RAT, DOG, AND MAN
Schwartz, M. A., Koechlin, B. A., Postma, E., et al. (1965) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27131-2 · Cited by 235 · see citing works
Development of Alcohol Dehydrogenase Activity in the Human Liver
Pikkarainen, P. H., & Räihä, N. C. R. (1967) · Pediatric Research · doi:10.1203/00006450-196705000-00001 · Cited by 205 · see citing works
Blood Level Distribution Patterns of Diazepam and its Major Metabolite in Man
Silva, J. A. F. D., Koechlin, B. A., & Bader, G. (1966) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600550706 · Cited by 200 · see citing works
Relationship Between Drug Concentration in Plasma or Serum and Amount of Drug in the Body
Gibaldi, M., Nagashima, R., & Levy, G. (1969) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600580210 · Cited by 181 · see citing works
Mirkin, B. L. (1971) · The Journal of Pediatrics · doi:10.1016/s0022-3476(71)80025-2 · Cited by 162 · see citing works
The presence of a monooxygenase system in human fetal liver microsomes
Yaffe, S. J., Rane, A., Sjöqvist, F., et al. (1970) · Life Sciences · doi:10.1016/0024-3205(70)90038-x · Cited by 146 · see citing works
Intravenous Diazepam in the Treatment of Prolonged Seizure Activity
Prensky, A. L., RAFF, M. C., Moore, M. J., & Schwab, R. S. (1967) · New England Journal of Medicine · doi:10.1056/nejm196704062761404 · Cited by 104 · see citing works
Placental transfer and fetal metabolism of diazepam in early human pregnancy
Idänpään-Heikkilä, J. E., Jouppila, P. I., Puolakka, J. O., & Vorne, M. S. (1971) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(71)90282-1 · Cited by 84 · see citing works
3,4‐Benzpyrene and N‐Methylaniline Metabolizing Enzymes in the Immature Human Foetus and Placenta*
Pelkonen, O., Arvela, P. I., & Kärki, N. T. (1972) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1972.tb00670.x · Cited by 62 · see citing works
Vest, M. F., & Rossier, R. (1963) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1963.tb36958.x · Cited by 58 · see citing works
Effect of Diazepam Administered to Mothers During Labour on Temperature Regulation of Neonate
Owen, J. R., Irani, S. F., & Blair, A. W. (1972) · Archives of Disease in Childhood · doi:10.1136/adc.47.251.107 · Cited by 55 · see citing works
Drug Metabolism in the Human Fetus and Newborn Infant
Rane, A., & Sjöqvist, F. (1972) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(16)32665-7 · Cited by 55 · see citing works
Conjugation Reactions in the Newborn Infant: The Metabolism of Para-aminobenzoic Acid
Vest, M. F., & Salzberg, R. (1965) · Archives of Disease in Childhood · doi:10.1136/adc.40.209.97 · Cited by 51 · see citing works
Pelkonen, O., Vorne, M. S., Jouppila, P. I., et al. (1971) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1971.tb00613.x · Cited by 48 · see citing works
Diazepam (valium) as an adjunct in obstetric analgesia.
Ce, F., Rudolph, A. J., & Mm, D. (1969) · PubMed · Cited by 46 · see citing works
Studies on oxidative drug metabolism in thefull-term newborn infant
Nitowsky, H. M., Matz, L., & Berzofsky, J. A. (1966) · The Journal of Pediatrics · doi:10.1016/s0022-3476(66)80310-4 · Cited by 31 · see citing works
Belvedere, G., Tognoni, G., Frigerio, A., et al. (1972) · Analytical Letters · doi:10.1080/00032717208062118 · Cited by 29 · see citing works
Self-citationSERENI, F., & Principi, N. (1968) · Annual Review of Pharmacology · doi:10.1146/annurev.pa.08.040168.002321 · Cited by 28 · see citing works
Self-citationSERENI, F., Perletti, L., Marubini, E., et al. (1968) · Pediatric Research · doi:10.1203/00006450-196801000-00003 · Cited by 27 · see citing works
Self-citationLevels of diazepam in adipose tissue of rats, mice and man
Marcucci, F., Fanelli, R., Frova, M., et al. (1968) · European Journal of Pharmacology · doi:10.1016/0014-2999(68)90035-6 · Cited by 22 · see citing works
Reinicke, C., Rogner, G., Frenzel, J., et al. (1970) · European Journal of Clinical Pharmacology · doi:10.1007/bf00420345 · Cited by 14 · see citing works
Untersuchungen �ber die Pharmakokinetik von Nalidixins�ure bei Kindern verschiedenen Alters
Rohwedder, H. J., Simon, C., K�bler, W., et al. (1970) · European Journal of Pediatrics · doi:10.1007/bf00438810 · Cited by 13 · see citing works
Tissue distribution and urinary excretion of a tetracycline derivative in newborn and older infants
SERENI, F., Perletti, L., Manfredi, N., et al. (1965) · The Journal of Pediatrics · doi:10.1016/s0022-3476(65)80254-2 · Cited by 12 · see citing works
Self-citationUntersuchungen über die Pharmakokinetik von Gentamycin bei Kindern
Rohwedder, H. J., & Goll, U. (1970) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-0028-1108608 · Cited by 7 · see citing works
Drug metabolism in the human fetus and newborn infant
Berman, E. J. (1972) · Journal of Pediatric Surgery · doi:10.1016/0022-3468(72)90028-0 · Cited by 4 · see citing works
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Research works printed but not linked: 2
- GARATTINI, S., F. MARCUCCI, P. L. MORSELLI, E. MUSSINI: The significance of measuring blood levels of benzodiazepines. In: Proceedings Symposium British Pharmacological Society, London 1972, in press
- HORNING, M. G., D. HARVEY, E. C HORNING, R. M. HILL: GCMS study of drug metabolites resulting from the expoide-diol pathway. In: FRIGERIO, A.: Proceedings of International Symposium on Gas Chromatography-Mass Spectrometry. Tamburini Pub- lisher, Milano 1972
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Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics
Riss, J., Cloyd, J., Gates, J., & Collins, S. (2008) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2008.01004.x · Cited by 511 · see citing works
Pharmacokinetic Optimisation of Benzodiazepine Therapy for Acute Seizures: Focus on Delivery Routes
Rey, E., Tr??luyer, J.-M., & Pons, G. (1999) · Clinical Pharmacokinetics · doi:10.2165/00003088-199936060-00003 · Cited by 265 · see citing works
Committee on Drugs (1998) · PEDIATRICS · doi:10.1542/peds.101.6.1079 · Cited by 234 · see citing works
Kienitz, R., Kay, L., Beuchat, I., Gelhard, S., von Brauchitsch, S., Mann, C., Lucaciu, A., Schäfer, J.-H., Siebenbrodt, K., Zöllner, J.-P., et al. (2022) · CNS Drugs · doi:10.1007/s40263-022-00940-2 · Cited by 139 · see citing works
Teratogenic effects of benzodiazepine use during pregnancy
Laegreid, L., Olegrd, R., Walström, J., & Conradi, N. (1989) · The Journal of Pediatrics · doi:10.1016/s0022-3476(89)80619-5 · Cited by 123 · see citing works
- Authors
- Morselli, P. L., Principi, N., Tognoni, G., Reali, E., Belvedere, G., Standen, S. M., & Sereni, F.
- Affiliations
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- ORCID
- Principi, N.
- Venue
- Journal of Perinatal Medicine
- Publisher
- Walter de Gruyter GmbH
- Published
- 1973-01
- Volume
- 1
- Issue
- 2
- Pages
- 133-141
- ISSN
- 0300-5577 (ISSN-L)
- 1619-3997
- OpenAlex
- W2058141338
- Cited by
- 116
- References
- 25
- Citations by year
- 2024: 2 · 2022: 1 · 2019: 3 · 2018: 1 · 2017: 3 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- green
- edoc.hu-berlin.de
- Locations
- Journal of Perinatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- edoc Publication server (Humboldt University of Berlin) (submittedVersion)
- edoc Publication server (Humboldt University of Berlin)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- diazepam, drug elimination, drug metabolism, neonates, preterm infants, term infants, children, benzodiazepines, microsomal enzyme system, pharmacokinetics
- MeSH terms
- Age Factors, Child, Child, Preschool, Diazepam, Humans, Infant, Infant, Newborn, Infant, Premature
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