Role of Toll-like receptor/MYD88 signaling in neurodegenerative diseases
Abstract
Toll-like receptors (TLRs) are important innate immune proteins, and the activation of the TLRs results in the activation of intracellular signaling pathways, leading to the expression of proinflammatory cytokines that are essential to the identification and clearance of invading pathogens. TLR signaling occurs through adaptor proteins, most commonly myeloid differentiation primary response gene 88 (MyD88). It is now known that immune surveillance and inflammatory responses occur in neurodegenerative diseases and TLR/MYD88 signaling plays a critical role in these diseases. The included studies suggest a contribution for this signaling to the pathophysiology of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple system atrophy, and related disorders. In this review, a discussion of the recent findings in this field is presented.
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Activated TRAF6 induces the activation of TAK1 and TAB2/3, followed by the consequent activation of MAPK and NF-κB, leading to a cascade of inflammatory responses.
“Activated TRAF6 induces the activation of TAK1 and TAB2/3, followed by the consequent activation of mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB), leading to a cascade of inflammatory responses.279”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [279]
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- Authors
- Xiang, W., Chao, Z.-Y., & Feng, D.-Y.
- Affiliations
- Shandong University (CN)
- Corresponding author
- Feng, Du-Yi
- Venue
- Reviews in the Neurosciences
- Publisher
- Walter de Gruyter GmbH
- Published
- 2015-01-01
- Volume
- 26
- Issue
- 4
- Pages
- 407-14
- ISSN
- 0334-1763 (ISSN-L)
- 2191-0200
- OpenAlex
- W1968417243
- Cited by
- 62
- References
- 0
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 11 · 2022: 4 · 2021: 6 · 2020: 9 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 4
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Reviews in the Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- Toll-like receptors, MyD88, neurodegenerative diseases, innate immunity, neuroinflammation, inflammatory cytokines, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple system atrophy, TLR signaling pathways
- MeSH terms
- Animals, Humans, Signal Transduction, Neurodegenerative Diseases, Toll-Like Receptors, Myeloid Differentiation Factor 88
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