Genistein Antagonizes Inflammatory Damage Induced by β-amyloid Peptide in Microglia through TLR4 and NF-Κb

Signaling to NF-κB by Toll-like receptors

Kawai, T., & Akira, S. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.09.002 · Cited by 2,395 · see citing works

Inflammatory processes in Alzheimer's disease

Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782 · see citing works

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation.

Henn, A. (2009) · ALTEX · doi:10.14573/altex.2009.2.83 · Cited by 660 · see citing works

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation

Reed-Geaghan, E. G., Savage, J. C., Hise, A. G., & Landreth, G. E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3158-09.2009 · Cited by 591 · see citing works

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

Salminen, A., Huuskonen, J., Ojala, J., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.09.002 · Cited by 581 · see citing works

Role of the Toll-Like Receptor 4 in Neuroinflammation in Alzheimer’s Disease

Walter, S., Letiembre, M., Liu, Y., Heine, H., Penke, B., Hao, W., Bode, B., Manietta, N., Walter, J., Schulz-Schüffer, W., et al. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000110455 · Cited by 543 · see citing works

Toll-Like Receptors in Neurodegeneration

Okun, E., Griffioen, K., Lathia, J., Tang, S.-C., Mattson, M., & Arumugam, T. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.09.001 · Cited by 459 · see citing works

Inflammation, microglia, and alzheimer's disease

Cameron, B., & Landreth, G. E. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.10.006 · Cited by 440 · see citing works

Rifampicin Does not Significantly Affect the Expression of Small Heterodimer Partner in Primary Human Hepatocytes

Pávek, P., Stejskalová, L., Krausová, L., Bitman, M., Vrzal, R., & Dvořák, Z. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00001 · Cited by 378 · see citing works

Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors

Salminen, A., Ojala, J. O., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.01.001 · Cited by 350 · see citing works

Microglia Function in Alzheimer’s Disease

Solito, E., & Sastre, M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00014 · Cited by 347 · see citing works

Specific Inhibition of MyD88-Independent Signaling Pathways of TLR3 and TLR4 by Resveratrol: Molecular Targets Are TBK1 and RIP1 in TRIF Complex

Youn, H. S., Lee, J. Y., Fitzgerald, K. A., Young, H. A., Akira, S., & Hwang, D. H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.3339 · Cited by 268 · see citing works

Inflammatory Aspects of Alzheimer Disease and Other Neurodegenerative Disorders

Schwab, C., & McGeer, P. L. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13402 · Cited by 234 · see citing works

Screening of innate immune receptors in neurodegenerative diseases: A similar pattern

Letiembre, M., Liu, Y., Walter, S., Hao, W., Pfander, T., Wrede, A., Schulz-Schaeffer, W., & Fassbender, K. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.08.018 · Cited by 228 · see citing works

Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPARγ expression in cultured astrocytes

Valles, S. L., Dolz-Gaiton, P., Gambini, J., Borras, C., LLoret, A., Pallardo, F. V., & Viña, J. (2010) · Brain Research · doi:10.1016/j.brainres.2009.11.044 · Cited by 186 · see citing works

A Brief Historical Overview of the Past Two Decades of Soy and Isoflavone Research

Messina, M. J. (2010) · Journal of Nutrition · doi:10.3945/jn.109.118315 · Cited by 185 · see citing works

Neuroimmunomodulation in the Pathogenesis of Alzheimer’s Disease

Morales, I., Farías, G., & Maccioni, R. B. (2010) · Neuroimmunomodulation · doi:10.1159/000258724 · Cited by 162 · see citing works

Oligomers of beta-amyloid protein (Aβ1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain

Carrero, I., Gonzalo, M. R., Martin, B., Sanz-Anquela, J. M., Arévalo-Serrano, J., & Gonzalo-Ruiz, A. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.05.004 · Cited by 132 · see citing works

Simvastatin reduces secondary brain injury caused by cortical contusion in rats: Possible involvement of TLR4/NF-κB pathway

Chen, G., Zhang, S., Shi, J., Ai, J., Qi, M., & Hang, C. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2008.12.019 · Cited by 129 · see citing works

Effect of soy isoflavone extract supplements on bone mineral density in menopausal women: meta-analysis of randomized controlled trials.

Taku, K., Melby, M. K., Takebayashi, J., Mizuno, S., Ishimi, Y., Omori, T., & Watanabe, S. (2010) · PubMed · Cited by 120 · see citing works

Toll-like receptors are key players in neurodegeneration

Arroyo, D. S., Soria, J. A., Gaviglio, E. A., Rodriguez‐Galán, M. C., & Iribarren, P. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.05.006 · Cited by 117 · see citing works

Tetrandrine attenuates spatial memory impairment and hippocampal neuroinflammation via inhibiting NF-κB activation in a rat model of Alzheimer's disease induced by amyloid-β(1-42).

He, F.-Q., Qiu, B., Zhang, X.-H., Li, T.-K., Xie, Q., Cui, D.-J., Huang, X.-L., & Gan, H. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.103 · Cited by 113 · see citing works

Sustained oxidative stress inhibits NF-κB activation partially via inactivating the proteasome

Wu, M., Bian, Q., Liu, Y., Fernandes, A. F., Taylor, A., Pereira, P., & Shang, F. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.09.021 · Cited by 97 · see citing works

Isoflavones and cardiovascular disease

Cano, A., García‐Pérez, M. Á., & Tarín, J. J. (2010) · Maturitas · doi:10.1016/j.maturitas.2010.07.015 · Cited by 88 · see citing works

Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice

Frank, S., Copanaki, E., Burbach, G. J., Müller, U. C., & Deller, T. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.01.075 · Cited by 86 · see citing works

The TRIF/TBK1/IRF-3 activation pathway is the primary inhibitory target of resveratrol, contributing to its broad-spectrum anti-inflammatory effects

Kim, M. H., Yoo, D. S., Lee, S. Y., Byeon, S. E., Lee, Y. G., Min, T., Rho, H. S., Rhee, M. H., Lee, J.-H., & Cho, J. Y. (2011) · Die Pharmazie · doi:10.31083/ph.2011.0798 · Cited by 65 · see citing works

Soybean isoflavone alleviates β‐amyloid 1‐42 induced inflammatory response to improve learning and memory ability by down regulation of Toll‐like receptor 4 expression and nuclear factor‐κB activity in rats

Ding, B., Ma, W., He, L., Zhou, X., Yuan, L., Yu, H., Feng, J., & Xiao, R. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.04.002 · Cited by 65 · see citing works

The protective effect of dietary eicosapentaenoic acid against impairment of spatial cognition learning ability in rats infused with amyloid β(1–40)

Hashimoto, M., Hossain, S., Tanabe, Y., Kawashima, A., Harada, T., Yano, T., Mizuguchi, K., & Shido, O. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.08.009 · Cited by 64 · see citing works

Molecular basis for detection of invading pathogens in the brain

Falsig, J., van Beek, J., Hermann, C., & Leist, M. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21590 · Cited by 62 · see citing works

Genistein attenuates D-galactose-induced oxidative damage through decreased reactive oxygen species and NF-κB binding activity in neuronal PC12 cells

Hsieh, H.-M., Wu, W., & Hu, M. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.10.021 · Cited by 51 · see citing works

Garlic (Allium sativum) Extract Inhibits Lipopolysaccharide-Induced Toll-Like Receptor 4 Dimerization

Youn, H., Lim, H. J., Lee, H. J., Hwang, D. H., Yang, M., Jeon, R., & Ryu, J. (2008) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70434 · Cited by 49 · see citing works

An insight into the role of autophagy in cell responses in the aging and neurodegenerative brain.

Caballero, B., & Coto‐Montes, A. M. (2012) · PubMed · doi:10.14670/hh-27.263 · Cited by 45 · see citing works

Genistein inhibits mitochondrial-targeted oxidative damage induced by beta-amyloid peptide 25–35 in PC12 cells

Xi, Y., Yu, H., Ma, W., Ding, B., Ding, J., Yuan, L., Feng, J., & Xiao, R. (2011) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-011-9362-7 · Cited by 42 · see citing works

Neuroprotection of soyabean isoflavone co-administration with folic acid against β-amyloid 1-40-induced neurotoxicity in rats

Ma, W., Li, X., Yu, H., Yuan, L., Guo, A., Xiao, Y., Li, L., & Xiao, R. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509274757 · Cited by 41 · see citing works

Phytoestrogens genistein and daidzin enhance the acetylcholinesterase activity of the rat pheochromocytoma cell line PC12 by binding to the estrogen receptor

Isoda, H., Talorete, T. P. N., Kimura, M., Maekawa, T., Inamori, Y., Nakajima, N., & Seki, H. (2002) · Cytotechnology · doi:10.1023/a:1023903220539 · Cited by 34 · see citing works

Splanchnic projection to the orbital cortex of the cat

Korn, H. (1969) · Brain Research · doi:10.1016/0006-8993(69)90083-3 · Cited by 27 · see citing works

Mechanism of isoflavone aglycone’s effect on cognitive performance of senescence-accelerated mice

Yang, H., Jin, G., Ren, D., Si-Jing, L. U. O., & Zhou, T. (2011) · Brain and Cognition · doi:10.1016/j.bandc.2010.10.008 · Cited by 11 · see citing works

The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys

Rettberg, J. R., Hamilton, R. T., Mao, Z., To, J., Zhao, L., Appt, S. E., Register, T. C., Kaplan, J. R., & Brinton, R. D. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.012 · Cited by 10 · see citing works

[Changes of nuclear factor and inflammatory chemotactic factors in brain of patients with Alzheimer's disease].

Liao, Y., Guan, Z.-Z., & Ravid, R. (2011) · PubMed · Cited by 10 · see citing works

Pattern recognition receptors involved in the inflammatory attenuating effects of soybean isoflavone in β-amyloid peptides 1-42 treated rats

Yuan, L., Zhou, X. J., Li, D., Ma, W., Yu, H., Xi, Y., & Xiao, R. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.11.020 · Cited by 9 · see citing works

Anti-inflammatory Effects of Flavonoids in Neurodegenerative Disorders

Spagnuolo, C., Moccia, S., & Russo, G. L. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.09.001 · Cited by 458 · see citing works

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease

Seo, E.-J., Fischer, N., & Efferth, T. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2017.11.030 · Cited by 265 · see citing works

Genistein: A Review on its Anti-Inflammatory Properties

Goh, Y. X., Jalil, J., Lam, K. W., Husain, K., & Premakumar, C. M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.820969 · Cited by 253 · see citing works

Nutrition Facts in Multiple Sclerosis

Riccio, P., & Rossano, R. (2015) · ASN NEURO · doi:10.1177/1759091414568185 · Cited by 232 · see citing works

Phytochemicals targeting NF-κB signaling: Potential anti-cancer interventions

Chauhan, A., Islam, A., Prakash, H., & Singh, S. K. (2021) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2021.07.002 · Cited by 160 · see citing works

Proinflammatory Pathways: The Modulation by Flavonoids

Ribeiro, D., Freitas, M., Lima, J. L. F. C., & Fernandes, E. (2015) · Medicinal Research Reviews · doi:10.1002/med.21347 · Cited by 147 · see citing works

Epigallocatechin‐3‐Gallate Attenuates Microglial Inflammation and Neurotoxicity by Suppressing the Activation of Canonical and Noncanonical Inflammasome via TLR4/NF‐κB Pathway

Zhong, X., Liu, M., Yao, W., Du, K., He, M., Jin, X., Jiao, L., Ma, G., Wei, B., & Wei, M. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801230 · Cited by 129 · see citing works

Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?

Mamun, A. A., Shao, C., Geng, P., Wang, S., & Xiao, J. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.90982 · Cited by 134 · see citing works

Emerging Signal Regulating Potential of Genistein Against Alzheimer’s Disease: A Promising Molecule of Interest

Uddin, M. S., & Kabir, M. T. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00197 · Cited by 119 · see citing works

Autophagy-dependent mechanism of genistein-mediated elimination of behavioral and biochemical defects in the rat model of sporadic Alzheimer's disease

Pierzynowska, K., Podlacha, M., Gaffke, L., Majkutewicz, I., Mantej, J., Węgrzyn, A., Osiadły, M., Myślińska, D., & Węgrzyn, G. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.01.030 · Cited by 116 · see citing works

Intranasal Delivery of Genistein-Loaded Nanoparticles as a Potential Preventive System against Neurodegenerative Disorders

Rassu, G., Porcu, E. P., Fancello, S., Obinu, A., Senes, N., Galleri, G., Migheli, R., Gavini, E., & Giunchedi, P. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics11010008 · Cited by 107 · see citing works

Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases

Jang, C. H., Oh, J., Lim, J. S., Kim, H. J., & Kim, J.-S. (2021) · Foods · doi:10.3390/foods10030636 · Cited by 100 · see citing works

Molecular and Therapeutic Targets of Genistein in Alzheimer’s Disease

Devi, K. P., Shanmuganathan, B., Manayi, A., Nabavi, S. F., & Nabavi, S. M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0215-6 · Cited by 96 · see citing works

Dietary nutrition for neurological disease therapy: Current status and future directions

Mao, X., Yin, X., Guan, Q.-W., Xia, Q., Yang, N., Zhou, H., Liu, Z., & Jin, W. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107861 · Cited by 84 · see citing works

α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect

Liu, H., Zhang, X., Shi, P., Yuan, J.-Y., Jia, Q., Pi, C., Chen, T., Xiong, L., Chen, J., Tang, J., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02768-z · Cited by 70 · see citing works

Study on the neuroprotective effects of Genistein on Alzheimer’s disease

Duan, X., Li, Y., Xu, F., & Ding, H. (2021) · Brain and Behavior · doi:10.1002/brb3.2100 · Cited by 78 · see citing works

Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes

Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73 · see citing works

Targeting Microglia in Alzheimer’s Disease: Pathogenesis and Potential Therapeutic Strategies

Sun, Z., Zhang, X., So, K.-F., Jiang, W., & Chiu, K. (2024) · Biomolecules · doi:10.3390/biom14070833 · Cited by 71 · see citing works

Effects and Underlying Mechanisms of Bioactive Compounds on Type 2 Diabetes Mellitus and Alzheimer’s Disease

Li, R., Zhang, Y., Rasool, S., Geetha, T., & Babu, J. R. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8165707 · Cited by 72 · see citing works

Toll-like receptors in Alzheimer's disease

Momtazmanesh, S., Perry, G. L., & Rezaei, N. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577362 · Cited by 71 · see citing works

G protein-coupled estrogen receptor is involved in the anti-inflammatory effects of genistein in microglia

Du, Z., Feng, X., Li, N., Qu, J., Feng, L., Chen, L., & Chen, W. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.03.039 · Cited by 69 · see citing works

Role of Toll-like receptor/MYD88 signaling in neurodegenerative diseases

Xiang, W., Chao, Z.-Y., & Feng, D.-Y. (2015) · Reviews in the Neurosciences · doi:10.1515/revneuro-2014-0067 · Cited by 62 · see citing works

The multimodal action of genistein in Alzheimer's and other age-related diseases

Mas‐Bargues, C., Borrás, C., & Viña, J. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.03.021 · Cited by 59 · see citing works

Dietary soy isoflavone attenuated growth performance and intestinal barrier functions in weaned piglets challenged with lipopolysaccharide

Zhu, C., Wu, Y., Jiang, Z., Zheng, C., Wang, L., Yang, X., Ma, X., Gao, K., & Hu, Y. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.04.054 · Cited by 59 · see citing works

Neuroinflammation Mechanisms and Phytotherapeutic Intervention: A Systematic Review

Kaur, N., Chugh, H., Sakharkar, M. K., Dhawan, U., Chidambaram, S. B., & Chandra, R. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00427 · Cited by 58 · see citing works

Gliotoxicity and Glioprotection: the Dual Role of Glial Cells

Quincozes‐Santos, A., Santos, C. L., Almeida, R. R. D. S., da Silva, A., Thomaz, N. K., Costa, N. L. F., Weber, F. B., Schmitz, I., Medeiros, L. S., Medeiros, L., et al. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02574-9 · Cited by 57 · see citing works

Epigallocatechin gallate induces extracellular degradation of amyloid β-protein by increasing neprilysin secretion from astrocytes through activation of ERK and PI3K pathways

Yamamoto, N., Shibata, M., Ishikuro, R., Tanida, M., Taniguchi, Y., Ikeda‐Matsuo, Y., & Sobue, K. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.030 · Cited by 54 · see citing works

Modulation of neuro-inflammatory condition, acetylcholinesterase and antioxidant levels by genistein attenuates diabetes associated cognitive decline in mice

Rajput, M. S., & Sarkar, P. D. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.02.021 · Cited by 53 · see citing works

Inflammatory signaling pathways in the treatment of Alzheimer's disease with inhibitors, natural products and metabolites (Review)

Zheng, Y., Zhang, X., Zhang, R., Wang, Z., Gan, J., Gao, Q., Yang, L., Xu, P., & Jiang, X. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5314 · Cited by 52 · see citing works

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory

Chen, Z., Wang, X., Du, S., Liu, Q., Xu, Z., Guo, Y., & Lin, X. (2024) · Chinese Medicine · doi:10.1186/s13020-024-00900-6 · Cited by 54 · see citing works

Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-Κb to Halt Alzheimer's Disease

Uddin, M. S., Hasana, S., Ahmad, J., Hossain, M. F., Rahman, M. M., Behl, T., Rauf, A., Ahmad, A., Hafeez, A., Perveen, A., et al. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612826666201118092422 · Cited by 49 · see citing works

Bioassay-guided fractionation of ethyl acetate extract from Armillaria mellea attenuates inflammatory response in lipopolysaccharide (LPS) stimulated BV-2 microglia

Geng, Y., Zhu, S., Cheng, P., Lu, Z., Xu, H., Shi, J., & Xu, Z. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.01.005 · Cited by 46 · see citing works

Neuroinflammation in Alzheimer’s Disease: Microglia, Molecular Participants and Therapeutic Choices

Wang, H., Shen, Y., Chuang, H.-Y., Chiu, C., Ye, Y., & Zhao, L. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190503151648 · Cited by 42 · see citing works

Genistein: A Potential Natural Lead Molecule for New Drug Design and Development for Treating Memory Impairment

Fuloria, S., Yusri, M. A. A., Sekar, M., Gan, S. H., Rani, N. N. I. M., Lum, P. T., Ravi, S., Subramaniyan, V., Azad, A. K., Jeyabalan, S., et al. (2022) · Molecules · doi:10.3390/molecules27010265 · Cited by 41 · see citing works

Non-Enzymatic Antioxidants against Alzheimer’s Disease: Prevention, Diagnosis and Therapy

Varesi, A., Campagnoli, L. I. M., Carrara, A., Pola, I., Floris, E., Ricevuti, G., Chirumbolo, S., & Pascale, A. (2023) · Antioxidants · doi:10.3390/antiox12010180 · Cited by 45 · see citing works

Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: Evidence from preclinical studies

Ren, Y., & Qu, S. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102040 · Cited by 37 · see citing works

Unlocking the potential of flavonoids: Natural solutions in the fight against colon cancer

Hasibuan, P. A. Z., Simanjuntak, Y., Hey‐Hawkins, E., Lubis, M. F., Rohani, A. S., Park, M. N., Kim, B., & Syahputra, R. A. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116827 · Cited by 38 · see citing works

Genistein: mechanisms of action for a pleiotropic neuroprotective agent in stroke

Schreihofer, D. A., & Oppong‐Gyebi, A. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1391933 · Cited by 35 · see citing works

TLR4 inhibitor attenuates amyloid-β-induced angiogenic and inflammatory factors in ARPE-19 cells: Implications for age-related macular degeneration

Chen, L., Bai, Y., Zhao, M., & Jiang, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4890 · Cited by 33 · see citing works

Genistein Attenuates Isoflurane-Induced Neuroinflammation by Inhibiting TLR4-Mediated Microglial-Polarization in vivo and in vitro

Jiang, T., Xu, S., Shen, Y., Xu, Y., & Li, Y. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s304336 · Cited by 34 · see citing works

Phytochemical Compounds and Nanoparticles as Phytochemical Delivery Systems for Alzheimer’s Disease Management

Bakrim, S., Aboulaghras, S., Menyiy, N. E., Omari, N. E., Assaggaf, H. M., Lee, L., Montesano, D., Gallo, M., Zengin, G., Al-Dhaheri, Y., et al. (2022) · Molecules · doi:10.3390/molecules27249043 · Cited by 34 · see citing works

GPER and IGF-1R mediate the anti-inflammatory effect of genistein against lipopolysaccharide (LPS)-induced nigrostriatal injury in rats

Du, Z., Gu, Y., Xie, X., Zhang, M., Jiang, G.-Y., & Chen, W. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105989 · Cited by 31 · see citing works

Recent advances of small molecule JNK3 inhibitors for Alzheimer’s disease

Qin, P., Ran, Y., Liu, Y., Wei, C., Luan, X., Niu, H., Peng, J., Sun, J., & Wu, J. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.106090 · Cited by 31 · see citing works

Simultaneous and Dose Dependent Melanoma Cytotoxic and Immune Stimulatory Activity of Betulin

Pfarr, K., Danciu, C., Arlt, O., Neske, C., Dehelean, C. A., Pfeilschifter, J. M., & Radeke, H. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118802 · Cited by 31 · see citing works

Lactoferrin alleviates Western diet-induced cognitive impairment through the microbiome-gut-brain axis

He, Q., Zhang, L., Li, D., Wu, J., Guo, Y., Fan, J., Wu, Q., Wang, H., Wan, Z., Xu, J., et al. (2023) · Current Research in Food Science · doi:10.1016/j.crfs.2023.100533 · Cited by 31 · see citing works

Targeting the TLR4/NF-κB pathway in β-amyloid-stimulated microglial cells: A possible mechanism that oxysophoridine exerts anti-oxidative and anti-inflammatory effects in an in vitro model of Alzheimer’s disease

Chen, R., Wang, Z., Zhi, Z., Tian, J., Zhao, Y., & Sun, J. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.07.019 · Cited by 29 · see citing works

NF‐κB‐mediated inflammatory damage is differentially affected in SH‐SY5Y and C6 cells treated with 27‐hydroxycholesterol

Ma, W., Li, C., Zhao, L. Q., Wang, Y., & Xiao, R. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.1005 · Cited by 28 · see citing works

Sinensetin Attenuates Amyloid Beta25-35-Induced Oxidative Stress, Inflammation, and Apoptosis in SH-SY5Y Cells Through the TLR4/NF-κB Signaling Pathway

Zhi, Z., Tang, X., Wang, Y., Chen, R., & Ji, H. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03406-x · Cited by 29 · see citing works

Inflammatory signaling pathways in Alzheimer's disease: Mechanistic insights and possible therapeutic interventions

Almutary, A. G., Begum, M. Y., Kyada, A., Gupta, S. K., Jyothi, S. R., Chaudhary, K., Sharma, S., Sinha, A., Abomughaid, M. M., Imran, M., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102548 · Cited by 27 · see citing works

Microglial activation in Alzheimer's disease: The role of flavonoids and microRNAs

Medrano-Jiménez, E., Meza‐Sosa, K. F., Aragon, J. A. U., Secundino, I., Pedraza-Alva, G., & Pérez-Martínez, L. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr1021-531r · Cited by 26 · see citing works

Phytochemicals as Epigenetic Modulators in Chronic Diseases: Molecular Mechanisms

Cord, D., Rîmbu, M. C., Iordache, M. P., Albulescu, R., Pop, S., Tănase, C., & Popa, M.-L. (2025) · Molecules · doi:10.3390/molecules30214317 · Cited by 23 · see citing works

Mitigating neuroinflammation in Parkinson's disease: Exploring the role of proinflammatory cytokines and the potential of phytochemicals as natural therapeutics

Sharma, P. K., Kishore, A., De, I., Negi, S., Kumar, G., Bhardwaj, S., & Singh, M. P. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105604 · Cited by 24 · see citing works

Flavonoids as Potential Therapeutics Against Neurodegenerative Disorders: Unlocking the Prospects

Faysal, M. F., Dehbia, Z., Zehravi, M., Sweilam, S. H., Haque, M. A., Kumar, K. P., Chakole, R. D., Shelke, S. P., Sirikonda, S., Nafady, M. H., et al. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04177-x · Cited by 23 · see citing works

Geniposide attenuates Aβ 25–35 -induced neurotoxicity via the TLR4/NF-κB pathway in HT22 cells

Huang, X., Li, J., Tao, Y., Wang, X., Zhang, R.-L., Zhang, J., Su, Z., Huang, Q., & Deng, Y. (2018) · RSC Advances · doi:10.1039/c8ra01038b · Cited by 22 · see citing works

Genistein modulates the expression of Toll-like receptors in experimental autoimmune encephalomyelitis

Dias, A. T., de Castro, S. B. R., Alves, C. C. D. S., Evangelista, M. G., da Silva, L. C., Faza, D. R. D. L. R., Machado, M. A., Juliano, M. A., & Ferreira, A. P. (2018) · Inflammation Research · doi:10.1007/s00011-018-1146-7 · Cited by 21 · see citing works

Prophylactic effect of Biochanin A in lipopolysaccharide-stimulated BV2 microglial cells

Berköz, M., Krośniak, M., Özkan-Yılmaz, F., & Hunt, A. Ö. (2020) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2020.1769128 · Cited by 21 · see citing works

Anthocyanins Protect SK-N-SH Cells Against Acrolein-Induced Toxicity by Preserving the Cellular Redox State

Belkacemi, A., & Ramassamy, C. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150770 · Cited by 19 · see citing works

Suppressing Inflammation for the Treatment of Diabetic Retinopathy and Age-Related Macular Degeneration: Dazdotuftide as a Potential New Multitarget Therapeutic Candidate

Vofo, B. N., & Chowers, I. (2023) · Biomedicines · doi:10.3390/biomedicines11061562 · Cited by 18 · see citing works

Insights into prevention mechanisms of bioactive components from healthy diets against Alzheimer's disease

Wang, J., Yu, Z., Ye, P., & Xu, B. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109397 · Cited by 18 · see citing works

Integrating Gene Expression and Protein Interaction Data for Signaling Pathway Prediction of Alzheimer’s Disease

Kong, W., Zhang, J., Mou, X., & Yang, Y. (2014) · Computational and Mathematical Methods in Medicine · doi:10.1155/2014/340758 · Cited by 17 · see citing works

DFMG attenuates the activation of macrophages induced by co‑culture with LPC‑injured HUVE‑12 cells via the TLR4/MyD88/NF‑κB signaling pathway

Li, C., Yang, S., Zhang, Y., Cao, J., & Fu, X. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3511 · Cited by 17 · see citing works

Mannoside Glycolipid Conjugates Display Anti-inflammatory Activity by Inhibition of Toll-like Receptor-4 Mediated Cell Activation

Flacher, V., Neuberg, P., Point, F., Daubeuf, F., Muller, Q., Sigwalt, D., Fauny, J., Rémy, J.-S., Frossard, N., Wagner, A., et al. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00552 · Cited by 14 · see citing works

DFMG reverses proliferation and migration of vascular smooth muscle cells induced by co-culture with injured vascular endothelial cells via suppression of the TLR4-mediated signaling pathway

Li, C., Zhang, Y., Huang, H., Cao, J., & Fu, X. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8635 · Cited by 12 · see citing works

Plant based food bioactives: A boon or bane for neurological disorders

Choudhary, N., Tewari, D., Nabavi, S. F., Kashani, H. R. K., Lorigooini, Z., Filosa, R., Badrealam, K. F., Masoudian, N., & Nabavi, S. M. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2131729 · Cited by 11 · see citing works

Anti-amnesic and Neuroprotective Potential of Genistein Against Alzheimer’s Disease

Singh, N. K., Verma, N. K., Gupta, J. K., & Raghav, J. (2023) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-023-00452-0 · Cited by 10 · see citing works

A review on plant-based remedies for the treatment of multiple sclerosis

Alam, M. Z. (2023) · Annales Pharmaceutiques Françaises · doi:10.1016/j.pharma.2023.03.005 · Cited by 8 · see citing works

Thymoquinone-rich black cumin oil attenuates ibotenic acid-induced excitotoxicity through glutamate receptors in Wistar rats

Ittiyavirah, S. P., Kannan, R., Sathyan, A., Rajasree, R. S., Kuruniyan, M. S., Quadri, S. A., Elayadeth‐Meethal, M., & Naseef, P. P. (2022) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2022.10.007 · Cited by 9 · see citing works

Phytochemical Compounds Loaded to Nanocarriers as Potential Therapeutic Substances for Alzheimer’s Disease-Could They be Effective?

Polat, D. Ç., Karadağ, A. E., Köprülü, R. E. P., Karantas, I. D., Mutlu, G., Çağlar, E. Ş., Okur, M. E., Okur, N. Ü., & Siafaka, P. I. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220411104128 · Cited by 7 · see citing works

Genistein - A Broad-spectrum Bioactive Compound with Diverse Pharmacological Potential: A Systematic Review

Goswami, M., Kityania, S., Nath, R., Nath, P., Nath, D., Das, S., Sharma, B. K., & Talukdar, A. D. (2025) · Current Molecular Medicine · doi:10.2174/0115665240377727250703130718 · Cited by 6 · see citing works

Integrative Transcriptomic, Network, and Machine Learning Analyses Identify Genistein and Resveratrol-Associated Therapeutic Targets in Alzheimer’s Disease

Isıyel, M., Ceylan, H., & Demir, Y. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05973-y · Cited by 6 · see citing works

Genistein in the Treatment of Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Preclinical Studies

Lei, H., Dong, X., & Gao, Y. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c01891 · Cited by 6 · see citing works

Genistein Implications in Radiotherapy: Kill Two Birds with One Stone

Liu, X., Zheng, T., Bao, Y., Li, P., Zhao, T., Liu, Y., Wang, H., & Sun, C. (2025) · Molecules · doi:10.3390/molecules30010188 · Cited by 6 · see citing works

The Role of Flavonoids as Modulators of Inflammation and on Cell Signaling Pathways

Muschietti, L., Ulloa, J. L., & Redko, F. C. (2018) · Springer eBooks · doi:10.1007/978-3-030-00545-0_5 · Cited by 6 · see citing works

Dietary Polyphenols as Natural Modulators of NF‐κB Signaling in Inflammation‐Driven Non‐Communicable Diseases: Focus on Cancer

Dinislam, K., Shamsi, A., Tasqeruddin, S., & Shahwan, M. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.72027 · Cited by 5 · see citing works

Exploring the Endoplasmic Reticulum's Role in Alzheimer's Disease and Its Potential as a Therapeutic Target

Saleh, R. O., Jabir, M. S., Mohammed, J. S., Ahmad, I. S., Ganesan, S., Shankhyan, A., Nanda, A., Ray, S., Zwamel, A. H., & Hussein, A. R. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70405 · Cited by 6 · see citing works

Prevention of neurodegenerative disorders by nutraceuticals

Pistollato, F., & Sachana, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821038-3.00002-1 · Cited by 3 · see citing works

Soy isoflavones attenuate atrazine-induced neuroinflammation and dopaminergic neurotoxicity in the substantia nigra: Insights from the gut microbiota-LPS-TLR4/MyD88/NF-κB axis

Zhang, Y., Lv, Y., Wang, Y., Fu, W., Shi, X.-Y., Liu, J., Wen, J., Li, X., & Li, B. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107312 · Cited by 2 · see citing works

Discovery of natural compounds and their derivatives against neuroinflammation: Pharmacological mechanisms and structure-activity relationship

Xin, X., Zong, T., Hu, Z., Jin, L., Zhou, W., Sun, J., & Gao, L. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108934 · Cited by 2 · see citing works

Probing the interactions of genistein with HMGB1 through multi-spectroscopic and in-silico approaches

Kuang, Y., Shen, P., Ye, J., Raj, R., Ge, H., Yu, B., & Zhang, J. (2024) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2024.125385 · Cited by 2 · see citing works

Pathway and Genomics of Immunomodulator Natural Products

Wang, J., Ma, L., Zhou, F., Wang, F., Chen, L., & Xiao, J. (2022) · Springer eBooks · doi:10.1007/978-981-16-8117-2_4 · Cited by 2 · see citing works

Prevention of Neurodegenerative Disorders by Nutraceuticals

Pistollato, F., & Sachana, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802147-7.00002-4 · Cited by 1 · see citing works

Modulation of Tumor Immunity by Medicinal Plant or Functional Food-Derived Compounds

Wright, R. E., Joshee, N., & Parajuli, P. (2019) · Springer eBooks · doi:10.1007/978-3-030-31269-5_12

Anti-Inflammatory Nutrients and Nutraceuticals for Active and Healthy Aging

Goudarzi, S., & Abdollahi, M. R. (2020) · Springer eBooks · doi:10.1007/978-981-15-3552-9_8

Genistein and its use as a neuroprotective agent in stroke

Oppong‐Gyebi, A., & Schreihofer, D. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90052-2.00048-2

Targeting Microglial Phagocytosis for Alzheimer's Disease Management: Natural, Pharmacological, Nanoparticle, and Gene Therapy Approaches

Raghuvanshi, S., Mazumder, A., & Das, S. (2025) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273378092250623064748

Nanoparticles based on different generation adamantane dendrons : design, synthesis and self-assembly studies

Aloisi, A. (2017) · doi:10.70675/8590bcbdze494z4bbczb876z2fdc4cd14a65

Développement par génie tissulaire d’un modèle de peau humaine innervée, vascularisée et immunocompétente pour l’étude des réactions inflammatoires cutanées

Müller, Q. (2018) · theses.fr (ABES) · doi:10.70675/86d94a9az1f3ez4f45z9cdfzcbbb2714378d

Flavonoids and neurodegeneration: Structure-activity relationship and therapeutic insights

Paragas, D. S., Ortinero, C., Feliciano, M. A. M., Lazaro, S. E., Quitos, L. S., Gonzales, R. L., Hsieh, C.-Y., Chen, B.-Y., Hsueh, C., & Tsai, P. (2026) · Studies in natural products chemistry · doi:10.1016/b978-0-443-49142-9.00010-x

The use of three murine genetic models of Alzheimer’s disease reveals efficacy of 4′,5,7-trihydroxyisoflavone in alleviating cognitive deficits and reducing levels of amyloid-beta and hyperphosphorylated tau protein

Gaffke, L., Szulc, A., Podlacha, M., Myślińska, D., Pierzynowska, K., & Węgrzyn, G. (2026) · Laboratory Animal Research · doi:10.1186/s42826-026-00302-9

Genistein Alleviates β -Amyloid-Induced Inflammatory Damage Through Regulating Toll-Like Receptor 4/Nuclear Factor κ B

Ma, W., Ding, B., Yu, H., Yuan, L., Xi, Y., & Xiao, R. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2014.3150 · Cited by 41 · see citing works

Beta Amyloid Peptide (25-35) Leading to Inflammation Through Toll-Like Receptors and the Anti-inflammatory Effect of Genistein in BV-2 Cells

Yu, H., Li, X.-Y., Zhou, X. J., Yuan, L., Ma, W., Xi, Y., Zhao, X., Wu, J., & Xiao, R. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0063-z · Cited by 25 · see citing works

Genistein Inhibited Amyloid-β induced Inflammatory Damage in C6 Glial Cells

Zhao, X., Yuan, L., Yu, H., Xi, Y., Ma, W., Zhou, X. J., Ding, J., & Xiao, R. (2014) · Archives of Medical Research · doi:10.1016/j.arcmed.2013.12.008 · Cited by 17 · see citing works

Anti-inflammatory effects of genistein via suppression of the toll-like receptor 4-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglia

Jeong, J.-W., Lee, H. H., Han, M. H., Kim, G., Kim, W., & Choi, Y. H. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.01.012 · Cited by 130 · see citing works

Artemisinin Attenuates Amyloid-Induced Brain Inflammation and Memory Impairments by Modulating TLR4/NF-κB Signaling

Zhao, X., Huang, X., Yang, C., Jiang, Y., Zhou, W., & Zheng, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116354 · Cited by 57 · see citing works