Macrophage peroxisome proliferator activated receptor γ as a therapeutic target to combat Type 2 diabetes
Abstract
The peroxisome proliferator activated receptor gamma is a member of the nuclear receptor superfamily of ligand-dependent transcription factors and is the molecular target of antidiabetic thiazolidinediones that exert insulin sensitizing effects in adipose tissue, skeletal muscle and the liver. In addition to the well described effects of peroxisome proliferator activated receptor gamma in insulin target tissues, it is now apparent that its expression in macrophages is critical in the regulation of macrophage phenotype, whole body glucose metabolism and in mediating, in part, the antidiabetic actions of thiazolidinediones. As macrophages are major contributors to tissue inflammation and are resident in tissues responsible for maintaining glucose homeostasis, the therapeutic potential of these cells in the treatment of Type 2 diabetes is of significant clinical interest.
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PPARγ deficient mice exhibit impaired M2 macrophage function and susceptibility to diet-induced inflammation and insulin resistance.
“Studies in PPARγ deficient mice exhibit impaired M2 macrophage function and susceptibility to diet-induced inflammation and insulin resistance [29,65–67].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [65]
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- Authors
- Pascual, G., Ricote, M., & Hevener, A. L.
- Affiliations
- University of California San Diego (US)
- Spanish National Centre for Cardiovascular Research (ES)
- University of California, Los Angeles (US)
- Venue
- Expert Opinion on Therapeutic Targets
- Publisher
- Informa Healthcare
- Published
- 2007-10-26
- Volume
- 11
- Issue
- 11
- Pages
- 1503-1520
- ISSN
- 1472-8222 (ISSN-L)
- 1744-7631
- OpenAlex
- W2110759243
- Cited by
- 12
- References
- 9
- Citations by year
- 2022: 1 · 2016: 2 · 2012: 2
- FWCI
- 0.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Therapeutic Targets (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 60484, K01DK060484, R21DK073227, DK-073227)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- PPARγ, macrophages, type 2 diabetes, thiazolidinediones, insulin sensitivity, macrophage phenotype, glucose homeostasis, inflammation, nuclear receptors, adipose tissue, skeletal muscle, liver
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Gene Expression Regulation, Glucose, Homeostasis, Humans, Hypoglycemic Agents, Macrophages, Drug Delivery Systems, Thiazolidinediones, PPAR gamma
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