Long-Term Effects of Placental Growth on Overweight and Body Composition
Open accessAbstract
Obesity is programmed in utero and small babies generally have small placentas. In some circumstances, an undernourished fetus can expand its placental surface to extract more nutrients. We hypothesize that this results in an imbalanced nutrient supply to the fetus leading to obesity. To determine whether placental size determines overweight and body composition, we studied 2003 subjects in adult life. Associations between placental surface area and indices of overweight were restricted to people who carried the Pro12Pro genotype of the PPARγ2 gene. For every 1 SD increase in placental surface area, the odds ratio for overweight was 1.37 (95% CI 1.10 to 1.71;P=0.005). Expansion of the placental surface in compensation for fetal undernutrition increases the risk of overweight and a higher body fat percentage in people carrying the Pro12Pro genotype. We suggest that similar underlying multifactorial mechanisms affect the development of obesity in general.
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The degree to which a placenta deviates from being perfectly round has predictive value for specific diseases.
“Because the Helsinki data allow so many comparisons with a variety of diseases, it has become clear that the degree to which a placenta deviates from being perfectly round has a predictive value for specific diseases.”
From Placental Origins of Chronic Disease (2016) · cites this paper as [172]
Among about 6,000 placentas in the Helsinki Birth Cohort, the placentas were some 2.6 cm longer in one direction than in the other.
“Among ~6,000 placentas in the Helsinki Birth Cohort, the placentas were some 2.6 cm longer in one direction than in the other (172).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [172]
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- Authors
- Eriksson, J. G., Gelow, J., Thornburg, K. L., Osmond, C., Laakso, M., Uusitupa, M., Lindi, V., Kajantie, E., & Barker, D. J. P.
- Affiliations
- University of Helsinki (FI)
- Oregon Health & Science University (US)
- Southampton General Hospital (GB)
- Kuopio University Hospital (FI)
- University of Eastern Finland (FI)
- Helsinki University Hospital (FI)
- Corresponding author
- Eriksson, Johan G.
- ORCID
- Venue
- International Journal of Pediatrics
- Publisher
- Hindawi Limited
- Published
- 2012
- Volume
- 2012
- Pages
- 1-6
- ISSN
- 1687-9740 (ISSN-L)
- 1687-9759
- PMC
- PMC3337610
- OpenAlex
- W2061763044
- Cited by
- 14
- References
- 27
- Citations by year
- 2024: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 2 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Pediatrics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Jalmari ja Rauha Ahokkaan Säätiö
- Päivikki ja Sakari Sohlbergin Säätiö
- Signe ja Ane Gyllenbergin Säätiö
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- placental development, placental surface area, fetal malnutrition, fetal programming, obesity, overweight, body composition, body fat percentage, PPARγ2, Pro12Ala polymorphism, fetal nutrient supply
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