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Cited by 150Cell death mechanisms and regulationAutophagy in Disease and TherapyPI3K/AKT/mTOR signaling in cancer

Targeting disease through novel pathways of apoptosis and autophagy

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Maiese, Kenneth, Chong, Zhao Zhong, Shang, Yan Chen, Wang, Shaohui·2012·Expert Opinion on Therapeutic Targets
DOI 10.1517/14728222.2012.719499PMC PMC3500415
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Abstract

INTRODUCTION: Apoptosis and autophagy impact cell death in multiple systems of the body. Development of new therapeutic strategies that target these processes must address their complex role during developmental cell growth as well as during the modulation of toxic cellular environments. AREAS COVERED: Novel signaling pathways involving Wnt1-inducible signaling pathway protein 1 (WISP1), phosphoinositide 3-kinase (PI3K), protein kinase B (Akt), β-catenin and mammalian target of rapamycin (mTOR) govern apoptotic and autophagic pathways during oxidant stress that affect the course of a broad spectrum of disease entities including Alzheimer's disease, Parkinson's disease, myocardial injury, skeletal system trauma, immune system dysfunction and cancer progression. Implications of potential biological and clinical outcome for these signaling pathways are presented. EXPERT OPINION: The CCN family member WISP1 and its intimate relationship with canonical and non-canonical wingless signaling pathways of PI3K, Akt1, β-catenin and mTOR offer an exciting approach for governing the pathways of apoptosis and autophagy especially in clinical disorders that are currently without effective treatments. Future studies that can elucidate the intricate role of these cytoprotective pathways during apoptosis and autophagy can further the successful translation and development of these cellular targets into robust and safe clinical therapeutic strategies.

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Authors
Maiese, K., Chong, Z. Z., Shang, Y. C., & Wang, S.
Affiliations
Rutgers Cancer Institute (US)
Corresponding author
Maiese, Kenneth
ORCID
Venue
Expert Opinion on Therapeutic Targets
Publisher
Informa Healthcare
Published
2012-08-27
Volume
16
Issue
12
Pages
1203-1214
ISSN
  • 1472-8222 (ISSN-L)
  • 1744-7631
DOI
10.1517/14728222.2012.719499
PMC
PMC3500415
OpenAlex
W2097566177
Cited by
150
References
7
Citations by year
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FWCI
1.25
Type
journal article
Language
en
Open access
Locations
  • Expert Opinion on Therapeutic Targets (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS059346-03S1, R01NS053946, NS059346-04)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
apoptosis, autophagy, WISP1, CCN family, Wnt signaling, PI3K/Akt signaling, β-catenin, mTOR, oxidative stress, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, myocardial injury, tumor progression, therapeutic target
MeSH terms
Autophagy, Disease, Humans, Proto-Oncogene Proteins, Apoptosis, Oxidative Stress, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, beta Catenin, CCN Intercellular Signaling Proteins, TOR Serine-Threonine Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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