Cited by 77Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

Sick fat: the good and the bad of old and new circulating markers of adipose tissue inflammation

Barchetta, I., Cimini, F. A., Ciccarelli, G., Baroni, M. G., Cavallo, M. G.·2019·Journal of Endocrinological Investigation

Abstract

Adipose tissue (AT) is one of the largest endocrine organs contributing to metabolic homeostasis. The functional pleiotropism of AT depends on its ability to secrete a large number of hormones, cytokines, extracellular matrix proteins and growth factors, all influencing many local and systemic physiological and pathophysiological processes. In condition of chronic positive energy balance, adipocyte expansion, hypoxia, apoptosis and stress all lead to AT inflammation and dysfunction, and it has been demonstrated that this sick fat is a main risk factor for many metabolic disorders, such as type 2 diabetes mellitus, fatty liver, cardiovascular disease and cancer. AT dysfunction is tightly associated with aberrant secretion of bioactive peptides, the adipocytokines, and their blood concentrations often reflect the expression in the AT. Despite the existence of an association between AT dysfunction and systemic pro-inflammatory state, most of the circulating molecules detectable in obese and dysmetabolic individuals do not identify specifically the condition of sick fat. Based on this premise, this review provides a concise overview of "classic" and novel promising adipocytokines associated with AT inflammation and discusses possible critical approaches to their interpretation in clinical practice.

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Crossref · 10.1007/s40618-019-01052-3

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Authors
Barchetta, I., Cimini, F. A., Ciccarelli, G., Baroni, M. G., & Cavallo, M. G.
Affiliations
Sapienza University of Rome (IT)
Corresponding author
  • Baroni, M. G.
  • Cavallo, M. G.
Venue
Journal of Endocrinological Investigation
Published
2019-05-09
Volume
42
Issue
11
Pages
1257-1272
ISSN
  • 0391-4097 (ISSN-L)
  • 1720-8386
OpenAlex
W2944626658
Cited by
77
References
239
Citations by year
2026: 3 · 2025: 9 · 2024: 5 · 2023: 18 · 2022: 9 · 2021: 13 · 2020: 17 · 2019: 3
FWCI
1.53
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Endocrinological Investigation (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
Funders
Sapienza Università di Roma (RM1161550687D69, RM11715C3FCB9431)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
adipose tissue inflammation, adipokines, circulating biomarkers, adipose tissue dysfunction, obesity, type 2 diabetes, hepatic steatosis, cardiovascular disease, cancer, metabolic disorders, adipokine secretion
MeSH terms
Adipose Tissue, Animals, Humans, Inflammation, Biomarkers, Intra-Abdominal Fat

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