Non-canonical IKKs, IKKϵ and TBK1, as novel therapeutic targets in the treatment of non-small cell lung cancer
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It is well known that non-canonical IκB kinases (IKK), IKKϵ and Tank-binding kinase 1 (TBK1), play a key role in anti-viral responses. Interestingly, they have recently emerged as novel survival kinases in several human cancers including lung cancer, given their roles in maintaining cancer cell survival and promoting oncogenic transformation. However, the molecular mechanisms by which IKKϵ/TBK1 are activated and IKKϵ/TBK1 mediate survival signal in cancer cells are still controversial. This article will briefly describe signaling pathways mediated by these non-canonical IKKs, especially focusing in lung cancer, and discuss their potential as molecular targets for lung cancer treatment.
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Whether TBK1 acts on autophagy or innate immunity may partially depend on its associations with specific adaptor proteins such as NAP1L1, TANK and TBKBP1/SINTBAD that bind in a mutually exclusive manner.
“Whether TBK1 acts on autophagy or innate immunity may partially depend on its associations with specific adaptor proteins such as NAP1L1 (nucleosome assembly protein 1), TANK and TBKBP1/SINTBAD that bind in a mutually exclusive manner [58,200,201].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [201]
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Autophagy and ALS: mechanistic insights and therapeutic implications
Chua, J. P., De Calbiac, H., Kabashi, E., & Barmada, S. J. (2022) · Autophagy · doi:10.1080/15548627.2021.1926656 · Cited by 189 · see citing works
- Authors
- Kim, J.-Y., Beg, A. A., & Haura, E. B.
- Affiliations
- Moffitt Cancer Center (US)
- Venue
- Expert Opinion on Therapeutic Targets
- Publisher
- Informa Healthcare
- Published
- 2013-08-28
- Volume
- 17
- Issue
- 10
- Pages
- 1109-1112
- ISSN
- 1472-8222 (ISSN-L)
- 1744-7631
- OpenAlex
- W2073855434
- Cited by
- 17
- References
- 21
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2016: 2 · 2015: 1 · 2014: 3
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Expert Opinion on Therapeutic Targets (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Moffitt Cancer Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- IKKε, TBK1, non-small cell lung cancer, tumor cell survival, oncogenic transformation, kinase signaling pathways, therapeutic target
- MeSH terms
- Animals, Humans, Lung Neoplasms, Signal Transduction, Protein Serine-Threonine Kinases, I-kappa B Kinase
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