Adiponectin: a key fat-derived molecule regulating inflammation

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

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Interleukin-10 and the Interleukin-10 Receptor

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Adipose Tissue as an Endocrine Organ

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C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus

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A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

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Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

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C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?

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Protection from obesity-induced insulin resistance in mice lacking TNF-α function

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Inflammation: the link between insulin resistance, obesity and diabetes

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Novel Modulator for Endothelial Adhesion Molecules

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Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

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Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1

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Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of <i>Ikkβ</i>

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Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-κB Signaling Through a cAMP-Dependent Pathway

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PPARγ Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein

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Adipose Tissue as an Endocrine Organ

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The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

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The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice

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The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice

Xu, A., Wang, Y., Keshaw, H., Xu, L. Y., Lam, K. S. L., & Cooper, G. J. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317797 · Cited by 1,298 · see citing works

Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages

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ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism

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Adiponectin and protection against type 2 diabetes mellitus

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Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study

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Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

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Beyond insulin resistance in NASH: TNF-α or adiponectin?

Hui, J. M., Hodge, A., Farrell, G. C., Kench, J. G., Kriketos, A., & George, J. (2004) · Hepatology · doi:10.1002/hep.20280 · Cited by 942 · see citing works

Adiponectin Expression From Human Adipose Tissue

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Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes

Wolf, A. M., Wolf, D. G. F., Rumpold, H. F., Enrich, B., & Tilg, H. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.145 · Cited by 821 · see citing works

Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans

Bruun, J. M., Lihn, A. S., Verdich, C., Pedersen, S. B., Toubro, S., Astrup, A. V., & Richelsen, B. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00110.2003 · Cited by 779 · see citing works

Interleukin-1, Interleukin-1 Receptors and Interleukin-1 Receptor Antagonist

Dinarello, C. A. (1998) · International Reviews of Immunology · doi:10.3109/08830189809043005 · Cited by 761 · see citing works

Induction of Adiponectin, a Fat-Derived Antidiabetic and Antiatherogenic Factor, by Nuclear Receptors

Iwaki, M., Matsuda, M., Maeda, N., Funahashi, T., Matsuzawa, Y., Makishima, M., & Shimomura, I. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1655 · Cited by 740 · see citing works

Adiponectin Specifically Increased Tissue Inhibitor of Metalloproteinase-1 Through Interleukin-10 Expression in Human Macrophages

Kumada, M., Kihara, S., Ouchi, N., Kobayashi, H., Okamoto, Y., Ohashi, K., Maeda, K., Nagaretani, H., Kishida, K., Maeda, N., et al. (2004) · Circulation · doi:10.1161/01.cir.0000127953.98131.ed · Cited by 555 · see citing works

The Relation of Markers of Inflammation to the Development of Glucose Disorders in the Elderly

Barzilay, J. I., Abraham, L., Heckbert, S. R., Cushman, M., Kuller, L. H., Resnick, H. E., & Tracy, R. P. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2384 · Cited by 543 · see citing works

Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes

Faßhauer, M., Kralisch, S., Klier, M., Lössner, U., Blüher, M., Klein, J. C., & Paschke, R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00090-1 · Cited by 534 · see citing works

Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin

Kamada, Y., Tamura, S., Kiso, S., Matsumoto, H., Saji, Y., Yoshida, Y., Fukui, K., Maeda, N., Nishizawa, H., Nagaretani, H., et al. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.08.029 · Cited by 480 · see citing works

Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine–endothelial cell interactions

Kawanami, D., Maemura, K., Takeda, N., Harada, T., Nojiri, T., Imai, Y., Manabe, I., Utsunomiya, K., & Nagai, R. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.104 · Cited by 470 · see citing works

Adiponectin differentially regulates cytokines in porcine macrophages

Wulster-Radcliffe, M. C., Ajuwon, K. M., Wang, J., Christian, J. A., & Spurlock, M. E. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.130 · Cited by 464 · see citing works

Adiponectin and its receptors in non-alcoholic steatohepatitis

Kaser, S., Moschen, A. R., Cayon, A., Kaser, A., Crespo, J., Pons-Romero, F., Ebenbichler, C. F., Patsch, J. R., & Tilg, H. (2004) · Gut · doi:10.1136/gut.2003.037010 · Cited by 412 · see citing works

Adiponectin protects LPS-induced liver injury through modulation of TNF-α in KK-Ay obese mice

Masaki, T., Chiba, S., Tatsukawa, H., Yasuda, T., Noguchi, H., Seike, M., & Yoshimatsu, H. (2004) · Hepatology · doi:10.1002/hep.20282 · Cited by 402 · see citing works

The Role of TNF-α in Insulin Resistance

Borst, S. E. (2004) · Endocrine · doi:10.1385/endo:23:2-3:177 · Cited by 369 · see citing works

Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL

Motoshima, H., Wu, X., Mahadev, K., & Goldstein, B. J. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.01.049 · Cited by 308 · see citing works

Anti-Inflammatory and Profibrinolytic Effect of Insulin in Acute ST-Segment–Elevation Myocardial Infarction

Chaudhuri, A., Janicke, D. M., Wilson, M. F., Tripathy, D., Garg, R., Bandyopadhyay, A., Calieri, J., Hoffmeyer, D., Syed, T., Ghanim, H., et al. (2004) · Circulation · doi:10.1161/01.cir.0000116762.77804.fc · Cited by 275 · see citing works

Leptin Concentrations in Relation to Body Mass Index and the Tumor Necrosis Factor-α System in Humans1

Mantzoros, C. S., Moschos, S. J., Avramopoulos, I., Kaklamani, V., Liolios, A. D., Doulgerakis, D. E., Griveas, I., Katsilambros, N. L., & Flier, J. S. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4323 · Cited by 272 · see citing works

Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARα, PPARγ, and LXR

Chinetti, G., Zawadski, C., Fruchart, J., & Staels, B. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.058 · Cited by 267 · see citing works

Induction of Adiponectin in Skeletal Muscle by Inflammatory Cytokines: <i>in Vivo</i> and <i>in Vitro</i> Studies

Delaigle, A. M., Jonas, J.-C., Bauche, I. B., Cornu, O., & Brichard, S. M. (2004) · Endocrinology · doi:10.1210/en.2004-0503 · Cited by 241 · see citing works

TNFα release by the nonfat cells of human adipose tissue

Fain, J. N., Bahouth, S. W., & Madan, A. K. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802594 · Cited by 202 · see citing works

Tumor Necrosis Factor-  in Sera of Obese Patients: Fall with Weight Loss

Dandona, P. (1998) · Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.83.8.2907 · Cited by 176 · see citing works

Circulating adiponectin levels during human endotoxaemia

Keller, P., Møller, K., Krabbe, K. S., & Pedersen, B. K. (2003) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2003.02264.x · Cited by 58 · see citing works

Cardiac remodeling in obesity

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Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue

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Current trends in inflammatory and immunomodulatory mediators in sepsis

Aziz, M., Jacob, A., Yang, W.-L., Matsuda, A., & Wang, P. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0912437 · Cited by 309 · see citing works

Normal-weight obese syndrome: early inflammation?

LORENZO, A. D., del Gobbo, V., Premrov, M. G., Bigioni, M., Galvano, F., & Renzo, L. D. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.1.40 · Cited by 262 · see citing works

Insulin dysregulation

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Obesity, its associated disorders and the role of inflammatory adipokines in companion animals

German, A. J., Ryan, V. H., German, A. C., Wood, I. S., & Trayhurn, P. (2010) · The Veterinary Journal · doi:10.1016/j.tvjl.2010.04.004 · Cited by 221 · see citing works

Role of Adiponectin in Central Nervous System Disorders

Bloemer, J., Pinky, P. D., Govindarajulu, M., Hong, H., Judd, R. L., Amin, R., Moore, T., Dhanasekaran, M., Reed, M. N., & Suppiramaniam, V. D. (2018) · Neural Plasticity · doi:10.1155/2018/4593530 · Cited by 182 · see citing works

Dietary Red and Processed Meat Intake and Markers of Adiposity and Inflammation: The Multiethnic Cohort Study

Chai, W., Morimoto, Y., Cooney, R. V., Franke, A. A., Shvetsov, Y. B., Marchand, L. L., Haiman, C. A., Kolonel, L. N., Goodman, M. T., & Maskarinec, G. (2017) · Journal of the American College of Nutrition · doi:10.1080/07315724.2017.1318317 · Cited by 113 · see citing works

Serum Adiponectin is not Associated with Risk of Colorectal Cancer

Lukanova, A., Söderberg, S., Kaaks, R., Jellum, E., & Stattin, P. E. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0836 · Cited by 104 · see citing works

Cytokines and inflammation in adipogenesis: an updated review

Jiang, N., Yao, L., Shu, T., & Wang, J. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0625-0 · Cited by 98 · see citing works

The Role of Adipokines in Understanding the Associations between Obesity and Depression

Taylor, V. H., & MacQUEEN, G. M. (2010) · Journal of Obesity · doi:10.1155/2010/748048 · Cited by 97 · see citing works

Adiponectin, an Unlocking Adipocytokine

Sun, Y., Xun, K., Wang, C., Zhao, H., Bi, H., Chen, X., & Wang, Y. (2009) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2008.00069.x · Cited by 94 · see citing works

Direct effects of leptin and adiponectin on peripheral reproductive tissues: a critical review: Table I

Kawwass, J. F., Summer, R. S., & Kallen, C. B. (2015) · Molecular Human Reproduction · doi:10.1093/molehr/gav025 · Cited by 80 · see citing works

Adiponectin and metabolic cardiovascular diseases: Therapeutic opportunities and challenges

Lei, X., Qiu, S., Yang, G., & Wu, Q. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.10.018 · Cited by 87 · see citing works

The Activity of Adiponectin in Bone

Naot, D., Musson, D. S., & Cornish, J. (2016) · Calcified Tissue International · doi:10.1007/s00223-016-0216-5 · Cited by 76 · see citing works

Adipokines and Obesity Are Associated with Colorectal Polyps in Adult Males: A Cross-Sectional Study

Comstock, S. S., Hortos, K., Kovan, B., McCaskey, S., Pathak, D. R., & Fenton, J. I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085939 · Cited by 63 · see citing works

N-Acetylcysteine and Allopurinol Synergistically Enhance Cardiac Adiponectin Content and Reduce Myocardial Reperfusion Injury in Diabetic Rats

Wang, T., Qiao, S., Lei, S., Liu, Y., Ng, K. F. J., Xu, A., Lam, K. S. L., Irwin, M. G., & Xia, Z. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023967 · Cited by 61 · see citing works

Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study

Dalamaga, Μ., Srinivas, S. K., Elovitz, M. A., Chamberland, J. P., & Mantzoros, C. S. (2011) · Metabolism · doi:10.1016/j.metabol.2011.03.021 · Cited by 56 · see citing works

Treatment of insulin resistance in obesity-associated type 2 diabetes mellitus through adiponectin gene therapy

Banerjee, A., Sharma, D., Trivedi, R., & Singh, J. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119357 · Cited by 51 · see citing works

Adiposopathy is a more rational treatment target for metabolic disease than obesity alone

Bays, H., & Dujovne, C. (2006) · Current Atherosclerosis Reports · doi:10.1007/s11883-006-0052-6 · Cited by 61 · see citing works

The cyclic metabolic switching theory of intermittent fasting

Mattson, M. P. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01254-5 · Cited by 45 · see citing works

Effects of telmisartan therapy on interleukin-6 and tumor necrosis factor-alpha levels: a meta-analysis of randomized controlled trials

for the ALICE (All-Literature Investigation of Cardiovascular Evidence) Group, Takagi, H., Mizuno, Y., Yamamoto, H., Goto, S.-N., & Umemoto, T. (2012) · Hypertension Research · doi:10.1038/hr.2012.196 · Cited by 43 · see citing works

Metabolic Obesity, Adipocytokines, and Inflammatory Markers in Asian Indians—CURES-124

Indulekha, K., Surendar, J., Anjana, R., Geetha, L., Gokulakrishnan, K., Pradeepa, R., & Mohan, V. (2015) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2014.0202 · Cited by 46 · see citing works

CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH)

Najjar, S. M., & Russo, L. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0407-3 · Cited by 40 · see citing works

Inflammatory markers in a 2-year soy intervention among premenopausal women

Maskarinec, G., Sofias, J. S., Franke, A. A., & Cooney, R. V. (2009) · Journal of Inflammation · doi:10.1186/1476-9255-6-9 · Cited by 34 · see citing works

Effect of continuous positive airway pressure treatment on serum adiponectin level and mean arterial pressure in male patients with obstructive sleep apnea syndrome

Zhang, X., Yin, K., Li, C., Jia, E., Li, Y., & Zhao-fang, G. A. O. (2007) · Chinese Medical Journal · doi:10.1097/00029330-200709010-00002 · Cited by 32 · see citing works

Replacing White Rice with Pre-Germinated Brown Rice Mildly Ameliorates Hyperglycemia and Imbalance of Adipocytokine Levels in Type 2 Diabetes Model Rats

Torimitsu, M., NAGASE, R., Yanagi, M., Homma, M., Sasai, Y., Ito, Y., HAYAMIZU, K., 野中翔太, Hosono, T., Mitsuo, K. I. S. E., et al. (2010) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.56.287 · Cited by 29 · see citing works

Characterization of adiponectin concentrations and molecular weight forms in serum, seminal plasma, and ovarian follicular fluid from cattle

Heinz, J. F. L., SINGH, S. P., Janowitz, U., Hoelker, M., Tesfaye, D., Schellander, K., & Sauerwein, H. (2014) · Theriogenology · doi:10.1016/j.theriogenology.2014.06.030 · Cited by 26 · see citing works

Resveratrol and SRT1720 Elicit Differential Effects in Metabolic Organs and Modulate Systemic Parameters Independently of Skeletal Muscle Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α)

Svensson, K., Schnyder, S., Albert, V., Cardel, B., Quagliata, L., Terracciano, L., & Handschin, C. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.590653 · Cited by 26 · see citing works

Adiponectin protects palmitic acid induced endothelial inflammation and insulin resistance via regulating ROS/IKKβ pathways

Zhao, W., Wu, C., Li, S., & Chen, X. (2016) · Cytokine · doi:10.1016/j.cyto.2016.09.005 · Cited by 25 · see citing works

Differential effects of propionate or β‐hydroxybutyrate on genes related to energy balance and insulin sensitivity in bovine white adipose tissue explants from a subcutaneous and a visceral depot1

Hosseini, A., Behrendt, C., Regenhard, P., Sauerwein, H., & Mielenz, M. (2011) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2011.01180.x · Cited by 25 · see citing works

Protective role of adiponectin against ethanol-induced gastric injury in mice

Yamamoto, S., Watabe, K., Araki, H., Kamada, Y., Kato, M., Kizu, T., Kiso, S., Tsutsui, S., Tsujii, M., Kihara, S., et al. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00324.2011 · Cited by 25 · see citing works

Review: Non-alcoholic fatty liver disease: natural history, pathogenesis and treatment

McAvoy, N. C., Ferguson, J., Campbell, I. W., & Hayes, P. C. (2006) · The British Journal of Diabetes · doi:10.1177/14746514060060060201 · Cited by 25 · see citing works

Adiponectin Inhibits LPS-Induced HMGB1 Release through an AMP Kinase and Heme Oxygenase-1-Dependent Pathway in RAW 264 Macrophage Cells

Elfeky, M., Kaede, R., Okamatsu‐Ogura, Y., & Kimura, K. (2016) · Mediators of Inflammation · doi:10.1155/2016/5701959 · Cited by 24 · see citing works

Introduction: The inflammation orchestra in adipose tissue

Arner, P. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01850.x · Cited by 21 · see citing works

Inflammatory markers in a randomised soya intervention among men

Maskarinec, G., Oum, R. E., Chaptman, A. K., & Ognjanovic, S. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508147389 · Cited by 20 · see citing works

Adiponectin as Well as Compressive Forces Regulate in vitro β-Catenin Expression on Cementoblasts via Mitogen-Activated Protein Kinase Signaling Activation

Yong, J., von Bremen, J., Ruiz‐Heiland, G., & Ruf, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645005 · Cited by 19 · see citing works

Serum Adiponectin Concentration Prior to Clinical Onset of Preeclampsia

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The relation of leptin and adiponectin with breast density among premenopausal women

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Obesity and Depression: Common Link and Possible Targets

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Relationship Between Obesity and Depression Considering the Inflammatory Theory

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Developmental Adipokines and Maternal Obesity InteractionsPreprint

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The mysterious association between adiponectin and endometriosis

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A Prospective Follow-Up of Adipocytokines in Cohort Patients With Gout

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Visceral adiposity and high adiponectin levels are associated with the prevalence of pancreatic cystic lesions

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Obesity in Humans and Dogs: Similarities, Links, and Differences

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Higher baseline serum adiponectin predicts better treatment remission in patients with generalized anxiety disorder treated with escitalopram

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Adiponectin and Inflammation

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Role of Adiponectin in Regulating Cytokines and Its Contribution to the Occurrence and Progression of Clinical Mastitis in Holstein Cows

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Protective Role of Adiponectin Against Ethanol Induced Gastric Injury in Mice

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Couch Potato: The Antithesis of Hormesis

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Protein pieces of adipose tissue secretory puzzle

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Obesity and Inflammation

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Novel Inflammatory and Immunomodulatory Mediators in Sepsis

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Adipokines, Inflammation, and Atherosclerosis

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NOVEL MECHANISMS IN INFLAMMATORY BOWEL DISEASE

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The Role of Systemic Inflammation in the Development of Equine Laminitis

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Evaluation of leptin and adiponectin levels in obese patients with acne vulgaris

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A Novel Blend of Momordica charantia and Stevia rebaudiana Extracts Ameliorates Metabolic Dysfunction and Muscle Atrophy in Type 2 Diabetic Mice

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Role of insulin resistance in atherosclerosis: underlying mechanisms and emerging stem cell-based therapeutic strategies

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Efeito da obesidade na atividade eosinofílica em crianças e adolescentes asmáticos atópicos

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Adiponectin and its Receptors as Potential Therapeutical Targets

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Adiponectin as an anti-inflammatory factor

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Adiponectin as a key player of inflammation

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Adiponectin as a key player in inflammation

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Adiponectin – a key adipokine in the metabolic syndrome

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