Cited by 156Dendrimers and Hyperbranched PolymersNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

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Drug delivery using multifunctional dendrimers and hyperbranched polymers

Paleos, Constantinos M, Tsiourvas, Dimitris, Sideratou, Zili, Tziveleka, Leto-Aikaterini·2010·Expert Opinion on Drug Delivery

DOI 10.1517/17425247.2010.534981

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Abstract

IMPORTANCE OF THE FIELD: The review presents the design strategy and synthesis of multifunctional dendrimers and hyperbranched polymers with the objective to develop effective drug delivery systems. AREAS COVERED IN THIS REVIEW: Well-characterized, commercially available dendritic polymers were subjected to functionalization for preparing drug delivery systems of low toxicity, high loading capacity, ability to target specific cells and transport through their membranes. This has been achieved by surface targeting ligands, which render the carriers specific to certain cells and polyethylene glycol groups, securing water solubility, stability and prolonged circulation. Moreover, transport agents facilitate transport through cell membranes while fluorescent probes detect their intracellular localization. A common feature of surface groups is multivalency, which considerably enhances their binding strength with complementary cell receptors. To these properties, one should also add the property of attaining high loading of active ingredients coupled with controlled and/or triggered release. WHAT THE READER WILL GAIN: Readers will be exposed to the strategy of synthesizing multifunctional polymers, aimed at the development of effective drug delivery systems. TAKE HOME MESSAGE: Multifunctional systems upgrade the therapeutic potential of drugs and, in certain cases, may even lead to the application of new bioactive compounds that would otherwise not be feasible.

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Authors: Paleos, C. M., Tsiourvas, D., Sideratou, Z., & Tziveleka, L.-A.
Affiliations: National Centre of Scientific Research "Demokritos" (GR)
ORCID: Tsiourvas, Dimitris
Sideratou, Zili
Tziveleka, Leto-Aikaterini
Venue: Expert Opinion on Drug Delivery
Publisher: Informa Healthcare
Published: 2010-11-17
Volume: 7
Issue: 12
Pages: 1387-1398
ISSN: 1742-5247 (ISSN-L)
1744-7593
DOI: 10.1517/17425247.2010.534981
OpenAlex: W2075479570
Cited by: 156
References: 113
Citations by year: 2026: 4 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 6 · 2021: 17 · 2020: 8 · 2019: 9 · 2018: 6 · 2017: 11 · 2016: 9 · 2015: 11 · 2014: 12 · 2013: 19 · 2012: 14
FWCI: 11.37
Type: journal article
Language: en
Open access: closed
Locations: Expert Opinion on Drug Delivery (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: dendrimers, hyperbranched polymers, drug delivery systems, surface functionalization, targeting ligands, polyethylene glycol, multivalency, cell membrane transport, fluorescent probes, controlled release, triggered release, drug loading capacity, polymer synthesis
MeSH terms: Animals, Drug Carriers, Humans, Polymers, Solubility, Drug Design, Gene Transfer Techniques, Dendrimers

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Drug delivery using multifunctional dendrimers and hyperbranched polymers

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