The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Solid lipid nanoparticles: an oral bioavailability enhancer vehicle
Abstract
INTRODUCTION: The therapeutic efficacy of perorally administered drugs is often obscured by their poor oral bioavailability (BA) and low metabolic stability in the gastrointestinal tract (GIT). Solid lipid nanoparticles (SLNs) have emerged as potential BA enhancer vehicles for various Class II, III and IV drug molecules. AREA COVERED: This review examines the recent advancements in SLN technology, with regards to oral drug delivery. The discussion critically examines the effect of various key constituents on SLN absorption and their applications in oral drug delivery. The relationship between the complexity of absorption (and various factors involved during absorption, including particle size), stability and the self-emulsifying ability of the lipids used has been explored. EXPERT OPINION: The protective effect of SLNs, coupled with their sustained/controlled release properties, prevents drugs/macromolecules from premature degradation and improves their stability in the GIT. An extensive literature survey reveals that direct peroral administration of SLNs improves the BA of drugs by 2- to 25-fold. Overall, the ease of large-scale production, avoidance of organic solvents and improvement of oral BA make SLNs a potential BA enhancer vehicle for various Class II, III and IV drugs.
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Cites
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Ganesan, P., & Narayanasamy, D. (2017) · Sustainable Chemistry and Pharmacy · doi:10.1016/j.scp.2017.07.002 · Cited by 434
Elmowafy, M., & Al-Sanea, M. M. (2021) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2021.07.015 · Cited by 382
Advances in Nanotechnology for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs
Liu, Y., Liang, Y., Yuhong, J., Xin, P., Han, J. L., Du, Y., Yu, X., Zhu, R., Zhang, M., Chen, W., et al. (2024) · Drug Design, Development and Therapy · doi:10.2147/dddt.s447496 · Cited by 365
Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics
Bourganis, V., Kammona, O., Alexopoulos, A., & Kiparissides, C. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.05.009 · Cited by 357
Luo, Y., Teng, Z., Li, Y., & Wang, Q. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.12.084 · Cited by 332
Metadata
- Authors
- Harde, H., Das, M., & Jain, S.
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa Healthcare
- Published
- 2011-08-11
- Volume
- 8
- Issue
- 11
- Pages
- 1407-1424
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W2002738924
- Cited by
- 281
- References
- 64
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- closed
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