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Chitosan: a potential polymer for colon-specific drug delivery system

Gulbake, Arvind, Jain, Sanjay K·2012·Expert Opinion on Drug Delivery
DOI 10.1517/17425247.2012.682148
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Abstract

Introduction There is an enormous growth and awareness of the potential applications of natural polymers for colon delivery of therapeutic bioactives. Chitosan (CH), a cationic polysaccharide, has a number of vital applications in the field of colon delivery and has attracted a great deal of attention from formulation scientists, academicians and environmentalists due to its unique properties. Areas covered CH has been widely explored for the delivery of drugs, peptides, proteins and genes to the colon for different therapeutic applications. Sustained and controlled delivery can be achieved with CH-based formulations like CH-coated tablets, capsules, beads, gels, microparticles and nanoparticles. This review mainly focuses on various aspects of CH-based formulations, particularly development of colon-specific delivery of drug. Expert opinion The vital properties of CH make it a versatile excipient, not only for sustained/controlled release applications but also as biodegradable, biocompatible, bioadhesive polymer. The colon is recognized as the preferred absorption site for orally administered protein and peptide drugs. The main problem associated with CH is limited solubility at higher pH due to reduced cationic nature, which also reduces mucoadhesiveness. The application of newer targeting moiety with CH-based formulations for highly site-specific delivery of bioactive has to be evaluated for further improvement of therapeutic index (bioavailability).

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Metadata

Authors
Gulbake, A., & Jain, S. K.
Venue
Expert Opinion on Drug Delivery
Publisher
Informa Healthcare
Published
2012-04-24
Volume
9
Issue
6
Pages
713-729
ISSN
  • 1742-5247
  • 1744-7593
DOI
10.1517/17425247.2012.682148
Cited by
81
References
2
Language
en

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CoChat. (2026). Citation check: Chitosan: a potential polymer for colon-specific drug delivery system. https://app.cochat.ai/papers/10.1517/17425247.2012.682148
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Gulbake, A., & Jain, S. K. (2012). Chitosan: a potential polymer for colon-specific drug delivery system. Expert Opinion on Drug Delivery. https://doi.org/10.1517/17425247.2012.682148