(Soft) capsules of wisdom: preventing myo-inositol malabsorption caused by coffee
Open accessAbstract
Development of new drugs or alternative formulations of a pre-existing drug face a number of issues that impact on the efficacy and success of the novel product or novel formulation. One of the maj...
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An oral gel preparation containing only LT4, glycerin, gelatin, and water has been developed, with LT4 as a liquid in a gelatin capsule.
“An oral gel preparation that contains only LT4, glycerin, gelatin, and water has been developed. The gelatin capsule contains LT4 as a liquid (109).”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [109]
The main text describes a developed L-T4 soft-gel capsule and says soft-gel capsules can contain liquid or semi-solid formulations. It does not specify that this L-T4 capsule contains liquid L-T4 or that its only ingredients are LT4, glycerin, gelatin, and water. The paper discusses a separate liquid L-T4 formulation dissolved in ethanol; page numbers were not available in our copy. (LLM, conf=0.86)
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Cites
Altered intestinal absorption of L-thyroxine caused by coffee
Benvenga, S., Bartolone, L., Pappalardo, M. A., Russo, A., Lapa, D., Giorgianni, G., Saraceno, G., & Trimarchi, F. (2008) · Thyroid · doi:10.1089/thy.2007.0222 · Cited by 191 · see citing works
Delayed Intestinal Absorption of Levothyroxine
BENVENGA, S., BARTOLONE, L., SQUADRITO, S., GIUDICE, F. L., & TRIMARCHI, F. (1995) · Thyroid · doi:10.1089/thy.1995.5.249 · Cited by 156 · see citing works
Self-citationPabla, D., Akhlaghi, F., & Zia, H. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.10.008 · Cited by 124 · see citing works
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Myo-inositol in a new pharmaceutical form: a step forward to a broader clinical use
Carlomagno, G., Grazia, S. D., Unfer, V., & Manna, F. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.662953 · Cited by 41 · see citing works
Myo-inositol soft gel capsules may prevent the risk of coffee-induced neural tube defects
Grazia, S. D., Carlomagno, G., Unfer, V., & Cavalli, P. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.701616 · Cited by 25 · see citing works
Saraceno, G. E., Vita, R. D., Trimarchi, F., & Benvenga, S. (2012) · 15th International & 14th European Congress of Endocrinology · Cited by 5 · see citing works
Self-citation[Dexamethasone-hydroxocobalamin combination in soft gelatine capsules].
Orzalesi, G., Gigli, P. M., & Canneri, E. (1968) · PubMed · Cited by 2 · see citing works
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- Carlomagno G, De Grazia S, Unfer V, Manna F. Myoinositol in a new h form: a step forward to a broader clinical use. Expert Opin Drug Deliv 2012;9:267-71
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Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928 · see citing works
“The gelatin capsule contains LT4 as a liquid (109).”
Gastrointestinal malabsorption of thyroxine
Virili, C., Antonelli, A., Santaguida, M. G., Benvenga, S., & Centanni, M. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00168 · Cited by 164 · see citing works
Self-citationLevothyroxine: conventional and novel drug delivery formulations.
Liu, H., Li, W., Zhang, W., Sun, S., & Chen, C. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnac030 · Cited by 63 · see citing works
Medications and Food Interfering with the Bioavailability of Levothyroxine: A Systematic Review
Liu, H., Lu, M., Hu, J., Fu, G., Feng, Q., Sun, S., & Chen, C. (2023) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s414460 · Cited by 29 · see citing works
- Authors
- Benvenga, S.
- Affiliations
- University of Messina (IT)
- Corresponding author
- Benvenga, Salvatore
- ORCID
- Benvenga, Salvatore
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa Healthcare
- Published
- 2012-09-05
- Volume
- 9
- Issue
- 10
- Pages
- 1177-1179
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W1994070232
- Cited by
- 6
- References
- 8
- Citations by year
- 2023: 1 · 2022: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Expert Opinion on Drug Delivery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Keywords
- coffee, capsule formulation, drug formulation, drug efficacy
- MeSH terms
- Biological Availability, Capsules, Coffee, Female, Gelatin, Gels, Humans, Hypothyroidism, Inositol, Intestinal Absorption, Neural Tube Defects, Risk Factors, Thyroxine, Vitamin B Complex
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